Proteasome Degradation (Mus musculus)

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1Deubiquitinates proteinsUbiquitin/E2 Complexp45 ATPase SubunitOxidatively DamagedCytosolic ProteinsBeta subunitsAMP Ubiquitin/E1 ComplexLid subunitsActivators of20S ComplexDegrades only PeptidesPresentation by MHC class 1Proteins to be DegradedUbiquitin/ProteinUnfolds and DegradesIntact ProteinsProteasome 26 S(PA700) (ATP dependent)Alpha subunitsProteasome 20SCatalytic Core (p45)E3/Protein2UbbPsmd4H2-Q10Psmc4H2-Q10Uba1Psmc3HLA-HUbiquitinPsmd7HLA-JPsmb2Psma3Psmb1Psmc2Psmb9Psmb5Hist1h2anUba7Uchl1H2-Q10IfngPsme2Uchl4Ube2d1Rpn2Psmc1Ube2d3Ube2d2aRpn1H2afzUbe2bPsmb7H2-Q10Psmd5Psmb4PSMA1Psme1Psmb8Psmd13Psma7UBCPsma6Psma4ATPPsmd11Psma2Psme3Psma5Psmd2Psmd6Psmd9Gm21972PSMB3Psmb6Psmd3H2-Q10Nedd4Psmb10Psmc6Psmd12H2afxH2-Q10PSMD10Psmd8Psmc5Psmc5


Description

No description

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP183 (r95110) with a 89.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia
  2. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95796view14:41, 19 January 2018MkutmonHomology conversion update
71732view20:17, 17 October 2013MaintBotAutomated update of data sources
71320view17:16, 17 October 2013MaintBotAutomated update of data sources
69110view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67615view11:33, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
62832view04:45, 3 May 2013MaintBotUpdated UniProt data source
59032view20:41, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41297view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
33047view21:58, 7 October 2009MaintBotAdded xrefs
32452view17:23, 15 August 2009MaintBotFixed text labels
32133view13:56, 14 August 2009MaintBotFixed group labels
31470view21:19, 13 August 2009MaintBotFixed text labels
30910view00:27, 30 July 2009MaintBotConverted from Homo sapiens
21770view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Proteasome Degradation]] moved to [[Pathway:WP519]]: Moved to stable identifier
8350view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Proteasome Degradation]] moved to [[Pathway:Mus musculus:Proteasome Degradation]]: Renaming species
7793view16:18, 18 December 2007MaintBotfixed category names
7486view12:42, 4 November 2007MaintBotAdded categories to GPML
6488view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Proteasome_Degradation]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
Gm21972GeneProductENSMUSG00000094638 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5707
H2-Q10GeneProductENSMUSG00000067235 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3106
H2afxGeneProductENSMUSG00000049932 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3014
H2afzGeneProductENSMUSG00000037894 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3015
HLA-HGeneProduct
HLA-JGeneProduct
Hist1h2anGeneProductENSMUSG00000069309 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8335
IfngGeneProductENSMUSG00000055170 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3458
Nedd4GeneProductENSMUSG00000032216 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4734
PSMA1GeneProductNo homologues found for original id L:5682
PSMB3GeneProductNo homologues found for original id L:5691
PSMD10GeneProductNo homologues found for original id L:5716
Psma2GeneProductENSMUSG00000015671 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5683
Psma3GeneProductENSMUSG00000060073 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5684
Psma4GeneProductENSMUSG00000032301 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5685
Psma5GeneProductENSMUSG00000068749 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5686
Psma6GeneProductENSMUSG00000021024 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5687
Psma7GeneProductENSMUSG00000027566 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5688
Psmb10GeneProductENSMUSG00000031897 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5699
Psmb1GeneProductENSMUSG00000014769 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5689
Psmb2GeneProductENSMUSG00000028837 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5690
Psmb4GeneProductENSMUSG00000005779 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5692
Psmb5GeneProductENSMUSG00000022193 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5693
Psmb6GeneProductENSMUSG00000018286 (Ensembl)
  • U13393
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5694
Psmb7GeneProductENSMUSG00000026750 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5695
Psmb8GeneProductENSMUSG00000024338 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5696
Psmb9GeneProductENSMUSG00000096727 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5698
Psmc1GeneProductENSMUSG00000021178 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5700
Psmc2GeneProductENSMUSG00000028932 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5701
Psmc3GeneProductENSMUSG00000002102 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5702
Psmc4GeneProductENSMUSG00000030603 (Ensembl)
  • PRS6 HUMAN
  • Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5704
Psmc5GeneProductENSMUSG00000020708 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5705
Psmc6GeneProductENSMUSG00000021832 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5706
Psmd11GeneProductENSMUSG00000017428 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5717
Psmd12GeneProductENSMUSG00000020720 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5718
Psmd13GeneProductENSMUSG00000025487 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5719
Psmd2GeneProductENSMUSG00000006998 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5708
Psmd3GeneProductENSMUSG00000017221 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5709
Psmd4GeneProductENSMUSG00000005625 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5710
Psmd5GeneProductENSMUSG00000026869 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5711
Psmd6GeneProductENSMUSG00000021737 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9861
Psmd7GeneProductENSMUSG00000039067 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5713
Psmd8GeneProductENSMUSG00000030591 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5714
Psmd9GeneProductENSMUSG00000029440 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5715
Psme1GeneProductENSMUSG00000022216 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5720
Psme2GeneProductENSMUSG00000079197 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5721
Psme3GeneProductENSMUSG00000078652 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10197
Rpn1GeneProductENSMUSG00000030062 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6184
Rpn2GeneProductENSMUSG00000027642 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6185
UBCGeneProductNo homologues found for original id L:7316
Uba1GeneProductENSMUSG00000001924 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7317
Uba7GeneProductENSMUSG00000032596 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7318
UbbGeneProductENSMUSG00000019505 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000170315
Ube2bGeneProductENSMUSG00000020390 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7320
Ube2d1GeneProductENSMUSG00000019927 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7321
Ube2d2aGeneProductENSMUSG00000091896 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7322
Ube2d3GeneProductENSMUSG00000078578 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7323
UbiquitinProteinNo homologues found for original id S:P0CG48
Uchl1GeneProductENSMUSG00000029223 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000154277
Uchl4GeneProductENSMUSG00000035337 (Ensembl) Homology Mapping from Homo sapiens to Mus musculus: Original ID = En:ENSG00000118939

Annotated Interactions

No annotated interactions
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