Histidine Biosynthesis (Saccharomyces cerevisiae)

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1-3H2OH+histidinolH2Ophosphoribulosylformimino-AICAR-PH2OH2OhistidinalNADH2OphosphoribosylformiminoAICAR-phosphateH+imidazole acetol-phosphate2-oxoglutarateL-histidonol-phosphatephosphoribosyl-ATPphosphoribosyl-AMPNADD-erythro-imidazole-glycerol-phosphateAICARHIS4HIS7HIS3ATPL-glutamineL-histidinePRPPHIS4HIS5HIS6HIS4L-glutamateNADHL-glutamateHIS2pyrophosphatepyrophosphateHIS1phosphateNADHHIS4


Description

Yeast cells contain 3 pathways for the synthesis of glutamate. Two pathways are mediated by two isoforms of glutamate dehydrogenase, encoded by GDH1 and GDH3 (CITS: [2989290])(CITS: [9287019]). The third pathway is driven by the combined activities of glutamine synthetase and glutamate synthase, encoded by GLN1 and GLT1, respectively (CITS: [2570348])(CITS: [8923741]). Studies of GDH1 and GDH3 regulation indicate that the cell uses these isoforms under different growth conditions (CITS: [11562373]). Expression of GDH3 is induced by ethanol and repressed by glucose, whereas GDH1 expression is high in either carbon source. Gdh1p uses alpha-ketoglutarate at a higher rate than Gdh3p. Thus, under fermentative growth conditions, Gdh1p drives glutamate biosynthesis, whereas in nonfermentable or limiting carbon sources, Gdh3p is the key isoform involved in balancing distribution of alpha-ketoglutarate to glutamate biosynthesis and energy metabolism.

SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Based on http://pathway.yeastgenome.org/biocyc/

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Bibliography

  1. Alifano P, Fani R, Liò P, Lazcano A, Bazzicalupo M, Carlomagno MS, Bruni CB; ''Histidine biosynthetic pathway and genes: structure, regulation, and evolution.''; Microbiol Rev, 1996 PubMed Europe PMC Scholia
  2. Denis V, Boucherie H, Monribot C, Daignan-Fornier B; ''Role of the myb-like protein bas1p in Saccharomyces cerevisiae: a proteome analysis.''; Mol Microbiol, 1998 PubMed Europe PMC Scholia
  3. Rébora K, Laloo B, Daignan-Fornier B; ''Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.''; Genetics, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
93001view18:23, 21 July 2017KhanspersModified description
93000view18:23, 21 July 2017Khanspersremoved GenMAPP notes
92888view09:47, 14 July 2017Jeffrey GoessensFixed some interactions
85639view16:17, 4 June 2016EgonwFixed the CAS number.
71894view10:22, 22 October 2013Mkutmonchanged AICAR to metabolite
70264view21:47, 15 July 2013MaintBotupdated to 2013 schema
69939view20:13, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67337view10:39, 26 June 2013Christine ChichesterOntology Term : 'histidine biosynthetic pathway' added !
41801view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
36660view22:53, 9 April 2010MaintBot
36621view22:32, 9 April 2010MaintBotDescription and bibliography added from SGD
21760view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Histidine Biosynthesis]] moved to [[Pathway:WP514]]: Moved to stable identifier
12748view08:00, 17 May 2008MaintBotautomated metabolite conversion
8783view14:09, 7 January 2008MaintBotAdded to category $category
8781view14:09, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AICARMetabolite3031-94-5 (CAS)
ATPMetabolite1927-31-7 (CAS)
HIS1GeneProductS000000857 (SGD)
HIS2GeneProductS000001921 (SGD)
HIS3GeneProductS000005728 (SGD)
HIS4GeneProductS000000535 (SGD)
HIS5GeneProductS000001378 (SGD)
HIS6GeneProductS000001282 (SGD)
HIS7GeneProductS000000452 (SGD)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
L-histidineMetabolite71-00-1 (CAS)
NADHMetabolite53-84-9 (CAS)
PRPPMetabolite97-55-2 (CAS)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions

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