PPAR Beta/Delta pathway (Homo sapiens)

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The Peroxisome Proliferator-Activated Receptor Delta forms a complex with the transcription factor BCL6, which prevents BCL6 from repressing proinflammatory cytokine genes. When a ligand binds to PPARD, the complex separates. PPARD can form a complex with NFkB or with RXRs to have varying effects.This pathway is based on the entry on the PPARG pathway on Nuclear Receptor Resource (https://nrresource.org/nuclear_receptors/peroxisome-proliferator-activated-receptor-delta-ppard-nr1c2/).

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Ontology Terms



  1. Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I; ''The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor.''; Int J Mol Sci, 2018 PubMed Europe PMC Scholia
  2. Wolf G; ''The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis.''; Nutr Rev, 2003 PubMed Europe PMC Scholia
  3. Kadayat TM, Shrestha A, Jeon YH, An H, Kim J, Cho SJ, Chin J; ''Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective.''; J Med Chem, 2020 PubMed Europe PMC Scholia


115726view08:39, 9 March 2021Marvin M2Changed ChEBI ID to primary ID
115725view08:36, 9 March 2021Marvin M2Ontology Term : 'signaling pathway' added !
115724view08:35, 9 March 2021Marvin M2Ontology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
115723view08:34, 9 March 2021Marvin M2New pathway

External references


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NameTypeDatabase referenceComment
BCL6GeneProductENSG00000113916 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CPT1AGeneProductENSG00000110090 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
EP300GeneProductEP300 (HGNC)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
LPLGeneProductENSG00000175445 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NCOA1GeneProductENSG00000084676 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PDK4GeneProductENSG00000004799 (Ensembl)
PLIN2GeneProductENSG00000147872 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PPARdelta agonistMetaboliteCHEBI:73730 (ChEBI)
PTGS2GeneProductENSG00000073756 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RELGeneProductENSG00000162924 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
TNFGeneProductTNF (HGNC)
UCP1GeneProductENSG00000109424 (Ensembl)
UCP2GeneProductENSG00000175567 (Ensembl)
UCP3GeneProductENSG00000175564 (Ensembl)
VCAM1GeneProductENSG00000162692 (Ensembl)

Annotated Interactions

No annotated interactions

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