STAT5 Activation (Homo sapiens)

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1111cytosolp-STAT5A, p-STAT5B Activators ofSTAT5:p-STAT5p-Y694-STAT5A Activators of STAT5Activators ofSTAT5:STAT5STAT5GRB2-1 p-Y699-STAT5B Autophosphorylated FLT3 p-Y-GAB2 STAT5A PTPN11 STAT5B Autophosphorylated FLT3 p-Y-GAB2 ATPSTAT5A GRB2-1 FLT3LG p-STAT5A, p-STAT5BADPPTPN11 FLT3LG STAT5B Activators of STAT5


Signal transducer and activator of transcription (STAT) constitutes a family of universal transcription factors. STAT5 refers to two highly related proteins, STAT5A and STAT5B, with critical function in cell survival and proliferation. Several upstream signals including cytokines and growth factors can trigger STAT5 activation. View original pathway at Reactome.


Pathway is converted from Reactome ID: 9645135
Reactome version: 73
Reactome Author 
Reactome Author: Varusai, Thawfeek

Quality Tags

Ontology Terms



  1. Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Zeng L, Richine B, Bowling JD, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky GE, Boswell HS, Zhang ZY, Kapur R, Chan RJ.; ''The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.''; PubMed Europe PMC Scholia


113223view11:29, 2 November 2020ReactomeTeamReactome version 74
112799view17:52, 9 October 2020DeSlOntology Term : 'transcription pathway' added !
112749view16:15, 9 October 2020ReactomeTeamNew pathway

External references


View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:456216 (ChEBI)
ATPMetaboliteCHEBI:30616 (ChEBI)
Activators of STAT5:STAT5ComplexR-HSA-9645118 (Reactome)
Activators of STAT5:p-STAT5ComplexR-HSA-9645119 (Reactome)
Activators of STAT5 R-HSA-9645129 (Reactome)
Activators of STAT5ComplexR-HSA-9645129 (Reactome)
Autophosphorylated FLT3 ProteinP36888 (Uniprot-TrEMBL)
FLT3LG ProteinP49771 (Uniprot-TrEMBL)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
PTPN11 ProteinQ06124 (Uniprot-TrEMBL)
STAT5A ProteinP42229 (Uniprot-TrEMBL)
STAT5B ProteinP51692 (Uniprot-TrEMBL)
STAT5ComplexR-HSA-1295523 (Reactome)
p-STAT5A, p-STAT5B R-HSA-507929 (Reactome)
p-STAT5A, p-STAT5BComplexR-HSA-507929 (Reactome)
p-Y-GAB2 ProteinQ9UQC2 (Uniprot-TrEMBL)
p-Y694-STAT5A ProteinP42229 (Uniprot-TrEMBL)
p-Y699-STAT5B ProteinP51692 (Uniprot-TrEMBL)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-9645137 (Reactome)
ATPR-HSA-9645137 (Reactome)
Activators of STAT5:STAT5ArrowR-HSA-9645126 (Reactome)
Activators of STAT5:STAT5R-HSA-9645137 (Reactome)
Activators of STAT5:p-STAT5ArrowR-HSA-9645137 (Reactome)
Activators of STAT5:p-STAT5R-HSA-9645134 (Reactome)
Activators of STAT5ArrowR-HSA-9645134 (Reactome)
Activators of STAT5R-HSA-9645126 (Reactome)
R-HSA-9645126 (Reactome) Signal transducer and activator of transcription (STAT5A/STAT5B) is a key component in several cell signaling and gene transcription process and regulated cell survival and proliferation. STAT5 is activated by multiple upstream activators including cytokines and growth factors. The process begins when an active upstream regulator binds STAT5 to initiate its phosphorylation (Sarah C et al, 2013).
R-HSA-9645134 (Reactome) Signal transducer and activator of transcription (STAT5A/STAT5B) is activated by a range of upstream signals including cytokines and growth factors. Activators bind and phosphorylate STAT5 following which STAT5 is released from the complex and translocates to the nucleus to regulate gene transcription (Sarah C et al, 2013).
R-HSA-9645137 (Reactome) Signal transducer and activator of transcription (STAT5A/STAT5B) is regulated by extracellular factors including cytokines and growth factors. Activators bind and phosphorylate STAT5 which results in its activation (Sarah C et al, 2013).
STAT5R-HSA-9645126 (Reactome)
p-STAT5A, p-STAT5BArrowR-HSA-9645134 (Reactome)
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