Nucleotide Excision Repair (Homo sapiens)

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1, 2XPC complexCul4-CSA complexTranscription factor II HDamage recognitionStalled polymeraseTranscription-coupled repairERCC6POLD1GTF2H4GTF2H55'5'3'3'5'5'3'3'Pol IIRBX1CUL4ACUL4BERCC8DDB1DNA unwinding5'5'3'3'ERCC5XPARPA1CDK7MNAT1CCNHERCC2ERCC3GTF2H1GTF2H2GTF2H35'5'3'3'ERCC1ERCC4Incision5'5'3'3'Excision and DNA synthesisPOLD2POLD3POLD4POLEPOLE2POLE3POLE4PCNARFC1RFC2RFC3RFC4RFC55'5'3'3'LIG1LigationGlobal genome repairCul4-DDB complexRBX1CUL4ACUL4BDDB2DDB1XPCRAD23ARAD23BCETN25'5'3'3'RPA2RPA3


Description

Nucleotide excision repair is a DNA repair mechanism that repairs DNA damaged by UV radiation.

This type of damage produces bulky distortions in the shape of DNA double helix due to the addition of DNA adducts, mostly thymine dimers and 6,4-photoproducts.

Recognition of distortions leads to the removal of a short single-stranded DNA segment that includes the lesion, creating a single-strand gap in the DNA, which is subsequently filled in by DNA polymerase, which uses the undamaged strand as a template. NER can be divided into two subpathways (Global genomic NER and Transcription coupled NER) that differ only in their recognition of helix-distorting DNA damage. Nucleotide excision repair has more complexity in eukaryotes.

Nucleotide excision repair (NER) is a particularly important DNA repair mechanism as evidenced by the severe human diseases that result from in-born genetic mutations of NER proteins including Xeroderma pigmentosum and Cockayne's syndrome.

This pathway was adapted from KEGG, REPAIRtoire and Wikipedia. The pathway layout is based on KEGG.

Quality Tags

Ontology Terms

 

Bibliography

  1. ''KEGG''; https://www.genome.jp/dbget-bin/www_bget?pathway+hsa03420,
  2. ''REPAIRtoire''; http://repairtoire.genesilico.pl/Pathway/2/,

History

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CompareRevisionActionTimeUserComment
108596view23:47, 9 January 2020KhanspersModified description
108048view00:38, 27 November 2019Khanspersadded references
108047view00:36, 27 November 2019KhanspersModified description
108046view00:27, 27 November 2019KhanspersModified description
108044view20:22, 26 November 2019KhanspersOntology Term : 'DNA repair pathway' added !
108043view20:21, 26 November 2019KhanspersOntology Term : 'nucleotide excision repair pathway' added !
108041view20:00, 26 November 2019KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCNHGeneProductENSG00000134480 (Ensembl)
CDK7GeneProductENSG00000134058 (Ensembl)
CETN2GeneProductENSG00000147400 (Ensembl)
CUL4AGeneProductENSG00000139842 (Ensembl)
CUL4BGeneProductENSG00000158290 (Ensembl)
DDB1GeneProductENSG00000167986 (Ensembl)
DDB2GeneProductENSG00000134574 (Ensembl)
ERCC1GeneProductENSG00000012061 (Ensembl)
ERCC2GeneProductENSG00000104884 (Ensembl)
ERCC3GeneProductENSG00000163161 (Ensembl)
ERCC4GeneProductENSG00000175595 (Ensembl)
ERCC5GeneProductENSG00000134899 (Ensembl)
ERCC6GeneProductENSG00000225830 (Ensembl)
ERCC8GeneProductENSG00000049167 (Ensembl)
GTF2H1GeneProductENSG00000110768 (Ensembl)
GTF2H2GeneProductENSG00000145736 (Ensembl)
GTF2H3GeneProductENSG00000111358 (Ensembl)
GTF2H4GeneProductENSG00000213780 (Ensembl)
GTF2H5GeneProductENSG00000272047 (Ensembl)
LIG1GeneProductENSG00000105486 (Ensembl)
MNAT1GeneProductENSG00000020426 (Ensembl)
PCNAGeneProductENSG00000132646 (Ensembl)
POLD1GeneProductENSG00000062822 (Ensembl)
POLD2GeneProductENSG00000106628 (Ensembl)
POLD3GeneProductENSG00000077514 (Ensembl)
POLD4GeneProductENSG00000175482 (Ensembl)
POLE2GeneProductENSG00000100479 (Ensembl)
POLE3GeneProductENSG00000148229 (Ensembl)
POLE4GeneProductENSG00000115350 (Ensembl)
POLEGeneProductENSG00000177084 (Ensembl)
RAD23AGeneProductENSG00000179262 (Ensembl)
RAD23BGeneProductENSG00000119318 (Ensembl)
RBX1GeneProductENSG00000100387 (Ensembl)
RFC1GeneProductENSG00000035928 (Ensembl)
RFC2GeneProductENSG00000049541 (Ensembl)
RFC3GeneProductENSG00000133119 (Ensembl)
RFC4GeneProductENSG00000163918 (Ensembl)
RFC5GeneProductENSG00000111445 (Ensembl)
RPA1GeneProductENSG00000132383 (Ensembl)
RPA2GeneProductENSG00000117748 (Ensembl)
RPA3GeneProductENSG00000106399 (Ensembl)
XPAGeneProductENSG00000136936 (Ensembl)
XPCGeneProductENSG00000154767 (Ensembl)

Annotated Interactions

No annotated interactions

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