HIPK2 in kidney fibrosis (Homo sapiens)

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1ROSDNA damageSIAH1NotchHIPK2Wnt / B-cateninTGF-Bp53NF-kBEpithelial-mesenchymaltransitionKIDNEY FIBROSISApoptosisInflammation


This pathway was adapted from Figure 6i of PMID: 22406746

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Ontology Terms



  1. Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, Mazloom AR, Chen EY, D'Agati V, Xiong H, Ross MJ, Chen N, Ma'ayan A, He JC; ''A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.''; Nat Med, 2012 PubMed Europe PMC Scholia


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108288view16:55, 4 December 2019AgustinGV
108287view16:54, 4 December 2019AgustinGV
108286view16:52, 4 December 2019AgustinGV
108025view21:15, 22 November 2019AgustinGV
108024view21:13, 22 November 2019AgustinGV
108023view21:10, 22 November 2019AgustinGV
108022view20:59, 22 November 2019AgustinGVOntology Term : 'renal fibrosis' added !
108021view20:58, 22 November 2019AgustinGVOntology Term : 'kidney disease pathway' added !
108019view20:55, 22 November 2019AgustinGVNew pathway

External references


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NameTypeDatabase referenceComment
HIPK2GeneProduct28996 (Entrez Gene)
NF-kBPathwayWP4562 (WikiPathways)
NotchPathwayWP268 (WikiPathways)
SIAH1GeneProduct6477 (Entrez Gene)
TGF-BPathwayWP3874 (WikiPathways)
Wnt / B-cateninPathwayWP4150 (WikiPathways)
p53PathwayWP707 (WikiPathways)

Annotated Interactions

No annotated interactions

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