Blood Clotting Cascade (Mus musculus)

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1Factor IXaFactor VaFactor XaTissue FactorFibrin Split Products+Thrombolysis Factor VIIaPlasminTissue InjuryThrombinIntrinsic PathwayFibrin MonomerFactor XIIaFactor XIaFactor XIIIaFibrin PolymerFactor VIIIa Extrinsic PathwayF10FgbF7F13bF2Serpinf2F5F8F9Prothrombinase ComplexF12F11PlauFgaPlgFibrinF10Serpinb2VwfF8aFggSerpine1Plat


Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered by a platelet and fibrin-containing clot to stop bleeding and begin repair of the damaged vessel. Disorders of coagulation can lead to an increased risk of bleeding (hemorrhage) or clotting (thrombosis). Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP272(r30179) with a 86% conversion rate.

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Ontology Terms



  1. Luchtman-Jones L, Broze GJ Jr; ''The current status of coagulation.''; Ann Med, 1995 PubMed Europe PMC Scholia


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71727view20:16, 17 October 2013MaintBotAutomated update of data sources
71317view17:16, 17 October 2013MaintBotAutomated update of data sources
69103view18:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67094view10:05, 26 June 2013Christine ChichesterOntology Term : 'coagulation cascade pathway' added !
62696view23:03, 1 May 2013MaintBotUpdated UniProt data source
41288view00:22, 2 March 2011MaintBotRemoved redundant pathway information and comments
35089view12:39, 11 February 2010Thomasfixed group positions, removed incorrect line
35080view12:22, 11 February 2010Thomasremoved brace
35076view12:15, 11 February 2010Thomasfixed some lines
35075view12:13, 11 February 2010Thomasadded literature
35069view12:02, 11 February 2010ThomasModified description
34387view22:50, 9 December 2009MaintBotAutomatic update of empty xrefs
32840view20:26, 14 September 2009MaintBotAdded xrefs
32110view13:48, 14 August 2009MaintBotFixed group labels
30846view00:06, 30 July 2009MaintBotConverted from Homo sapiens
21648view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Blood Clotting Cascade]] moved to [[Pathway:WP460]]: Moved to stable identifier
7928view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Blood Clotting Cascade]] moved to [[Pathway:Mus musculus:Blood Clotting Cascade]]: Renaming species
7589view16:02, 18 December 2007MaintBotfixed category names
7456view12:42, 4 November 2007MaintBotAdded categories to GPML
6418view22:18, 22 May 2007A.Kwagpml file for [[Mouse:Blood_Clotting_Cascade]]

External references


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NameTypeDatabase referenceComment
F10GeneProduct14058 (Entrez Gene)
F11GeneProduct109821 (Entrez Gene)
F12GeneProduct58992 (Entrez Gene)
F13bGeneProduct14060 (Entrez Gene)
F2GeneProduct14061 (Entrez Gene)
F5GeneProduct14067 (Entrez Gene)
F7GeneProduct14068 (Entrez Gene)
F8GeneProduct14069 (Entrez Gene)
F8aGeneProduct14070 (Entrez Gene)
F9GeneProduct14071 (Entrez Gene)
FgaGeneProduct14161 (Entrez Gene)
FgbGeneProduct110135 (Entrez Gene)
FggGeneProduct99571 (Entrez Gene)
PlatGeneProduct18791 (Entrez Gene)
PlauGeneProduct18792 (Entrez Gene)
PlgGeneProduct18815 (Entrez Gene)
Prothrombinase ComplexGeneProduct
Serpinb2GeneProduct18788 (Entrez Gene)
Serpine1GeneProduct18787 (Entrez Gene)
Serpinf2GeneProduct18816 (Entrez Gene)
VwfGeneProduct22371 (Entrez Gene)

Annotated Interactions

No annotated interactions
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