Neural Crest Cell Migration during Development (Homo sapiens)

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1NucleusInvasionIncreased level of EMT markersPIK3R6AKT3PIK3R4TRIOBDNFCDH11TWIST1NGEFMMP9PIK3CBARF1RAC1TIAM1MMP8PIK3CDAKT1JUNFOSPIK3CGSTAT3MMP2PIK3R3EPHB1RHOAF2RL2AKT2PIK3CAPAK1PIK3R5CDH11PPAKT3AKT1AKT2PNGFRNGFREPHB2EPHB3EPHB4EPHB6BDNFSTAT3MMP2PTWIST1MMP9RAC1PAK2PAK3PAK4PAK5PAK6CytokeletonremodelingCytoplasm


Description

During normal neuronal development, neural crest cells participate in migration and invasion processes. The growth factor, BDNF, binds to and activates NGFR (p75NTR) in various contexts, invoking signaling pathways that lead to transcriptional activation in the nucleus. Also see the closely related pathway, [Neural Crest Cells in Cancer](https://www.wikipathways.org/index.php/Pathway:WP4565).

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Ontology Terms

 

Bibliography

  1. Wislet S, Vandervelden G, Rogister B; ''From Neural Crest Development to Cancer and Vice Versa: How p75NTRand (Pro)neurotrophins Could Act on Cell Migration and Invasion?''; Front Mol Neurosci, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
103712view01:31, 29 March 2019AlexanderPicoModified description
103710view01:29, 29 March 2019AlexanderPicoModified description
103701view01:00, 29 March 2019AlexanderPicoOntology Term : 'migratory neural crest cell' added !
103700view00:59, 29 March 2019AlexanderPicoOntology Term : 'brain-derived neurotrophic factor signaling pathway' added !
103699view00:58, 29 March 2019AlexanderPicoOntology Term : 'signaling pathway' added !
103698view00:57, 29 March 2019AlexanderPicoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene) AKT
AKT2GeneProduct208 (Entrez Gene) AKT
AKT3GeneProduct10000 (Entrez Gene) AKT
ARF1GeneProduct375 (Entrez Gene)
BDNFGeneProduct627 (Entrez Gene) BDNF
CDH11GeneProduct1009 (Entrez Gene) Cadherin
EPHB1GeneProduct2047 (Entrez Gene) MMP
EPHB2GeneProduct2048 (Entrez Gene) MMP
EPHB3GeneProduct2049 (Entrez Gene) MMP
EPHB4GeneProduct2050 (Entrez Gene) MMP
EPHB6GeneProduct2051 (Entrez Gene) MMP
F2RL2GeneProduct2151 (Entrez Gene) MMP
FOSGeneProduct2353 (Entrez Gene) AP-1
JUNGeneProduct3725 (Entrez Gene) JUN/AP
MMP2GeneProduct4313 (Entrez Gene) MMP2
MMP8GeneProduct4317 (Entrez Gene) MMP
MMP9GeneProduct4318 (Entrez Gene) MMP
NGEFGeneProduct25791 (Entrez Gene)
NGFRGeneProduct4804 (Entrez Gene) p75(NTR)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
PAK5GeneProduct57144 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene) PI3K
PIK3CBGeneProduct5291 (Entrez Gene) PI3K
PIK3CDGeneProduct5293 (Entrez Gene) PI3K
PIK3CGGeneProduct5294 (Entrez Gene) PI3K
PIK3R3GeneProduct8503 (Entrez Gene) PI3K
PIK3R4GeneProduct30849 (Entrez Gene) PI3K
PIK3R5GeneProduct23533 (Entrez Gene) PI3K
PIK3R6GeneProduct146850 (Entrez Gene) PI3K
RAC1GeneProduct5879 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene) RhoA
STAT3GeneProduct6774 (Entrez Gene) STAT3
TIAM1GeneProduct7074 (Entrez Gene) Tiam
TRIOGeneProduct7204 (Entrez Gene) TRIO
TWIST1GeneProduct7291 (Entrez Gene) Twist1,

Annotated Interactions

No annotated interactions

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