FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma (Homo sapiens)

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1Diffuse large B-cell lymphomaCell proliferationPRC2 complexHistone H3Histone 2AH3H2AFB2H2AFB1MAP/ERK SignalingH2AMeUbMAPK1MAPK3DUSP6MAPK1MAPK3EEDEZH2SUZ12PCGF1BCORFBXL10BCL6DUSP6RNF2Non-canonical PRC1 complexH3F3AH3F3BHIST1H3DHIST1H3JHIST2H3AHIST2H3CHIST2H3DHIST1H3CHIST1H3GHIST1H3HHIST1H3AHIST1H3FHIST1H3BHIST1H3IHIST1H3EH2AFB3H2AFJH2AFVH2AFXH2AFYH2AFY2H2AFZ


Description

FBXL10, a member of Polycomb repressive complexes, is overexpressed in human diffuse large B-cell lymphoma tissues and cell lines. FBXL10 silences the expression of DUSP6 through recruitment of polycomb repressuive complexes, which leads to the deposition of repressive histone modifications in the DUPS6 promoter. DUSP6 is a ERK1/2 (MAPK1/MAPK3) phosphatase and with lower levels of DUSP6, ERK1/2 remain phosphorylated and thus activates downstream ERK/MAPK signaling and ultimately cell proliferation.

Based on figure 7 in Zhao et al

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Ontology Terms

 

Bibliography

  1. Zhao X, Wang X, Li Q, Chen W, Zhang N, Kong Y, Lv J, Cao L, Lin D, Xu G, Wu X; ''FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway.''; Cell Death Dis, 2018 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
103606view22:05, 20 March 2019KhanspersModified title
103605view22:05, 20 March 2019KhanspersModified title
103593view19:19, 19 March 2019KhanspersOntology Term : 'disease of cellular proliferation' added !
103592view19:18, 19 March 2019KhanspersModified description
103591view19:17, 19 March 2019KhanspersOntology Term : 'altered extracellular signal-regulated Raf/Mek/Erk signaling pathway' added !
103590view19:17, 19 March 2019KhanspersOntology Term : 'diffuse large B-cell lymphoma' added !
103589view19:16, 19 March 2019KhanspersModified description
103588view19:14, 19 March 2019KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BCL6GeneProductENSG00000113916 (Ensembl)
BCORGeneProductENSG00000183337 (Ensembl)
DUSP6GeneProductENSG00000139318 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FBXL10GeneProductENSG00000089094 (Ensembl)
H2AGeneProduct
H2AFB1GeneProductENSG00000274183 (Ensembl)
H2AFB2GeneProductENSG00000277858 (Ensembl)
H2AFB3GeneProductENSG00000277745 (Ensembl)
H2AFJGeneProductENSG00000246705 (Ensembl)
H2AFVGeneProductENSG00000105968 (Ensembl)
H2AFXGeneProductENSG00000188486 (Ensembl)
H2AFY2GeneProductENSG00000099284 (Ensembl)
H2AFYGeneProductENSG00000113648 (Ensembl)
H2AFZGeneProductENSG00000164032 (Ensembl)
H3GeneProduct
H3F3AGeneProductENSG00000163041 (Ensembl)
H3F3BGeneProductENSG00000132475 (Ensembl)
HIST1H3AGeneProductENSG00000275714 (Ensembl)
HIST1H3BGeneProductENSG00000274267 (Ensembl)
HIST1H3CGeneProductENSG00000278272 (Ensembl)
HIST1H3DGeneProductENSG00000197409 (Ensembl)
HIST1H3EGeneProductENSG00000274750 (Ensembl)
HIST1H3FGeneProductENSG00000277775 (Ensembl)
HIST1H3GGeneProductENSG00000273983 (Ensembl)
HIST1H3HGeneProductENSG00000278828 (Ensembl)
HIST1H3IGeneProductENSG00000275379 (Ensembl)
HIST1H3JGeneProductENSG00000197153 (Ensembl)
HIST2H3AGeneProductENSG00000203852 (Ensembl)
HIST2H3CGeneProductENSG00000203811 (Ensembl)
HIST2H3DGeneProductENSG00000183598 (Ensembl)
MAP/ERK SignalingPathway
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
PCGF1GeneProductENSG00000115289 (Ensembl)
RNF2GeneProductENSG00000121481 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)

Annotated Interactions

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