Inflammatory response pathway (Homo sapiens)

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Inflammation is a protective response of cells to pathogens, infection or tissue damage. It involves the coordinated communication of different immune cells and blood vessels through an intricate cascade of molecular signals. Inflammation can cause fever, cardiovascular pathology, allergy anaphylaxis, fibrosis, autoimmunity, etc.

The inflammatory response has four phases: inflammatory inducers (infection or tissue damage), inflammatory sensors (mast cells and macrophages), inflammatory mediators (cytokines, chemokines, etc.) and the tissues that are affected. Each phase has many options that are triggered based on the type pathogen introduced.

In addition, chronic inflammatory conditions, where an inducer is not well defined, are becoming more common. These conditions are of particular interest because they coincide with other diseases such as obesity, type 2 diabetes, atherosclerosis, neurodegenerative diseases and cancer. [1]

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Monahan J, Siegel N, Keith R, Caparon M, Christine L, Compton R, Cusik S, Hirsch J, Huynh M, Devine C, Polazzi J, Rangwala S, Tsai B, Portanova J; ''Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor.''; J Immunol, 1997 PubMed Europe PMC Scholia
  2. Greisenegger S, Zehetmayer S, Bauer P, Endler G, Ferrari J, Lang W, Janisiw M, Steiner L, Cheng S, Lalouschek W, Mannhalter C; ''Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.''; Clin Chem, 2009 PubMed Europe PMC Scholia


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116780view09:51, 14 May 2021EweitzModified title
106602view19:46, 10 September 2019KhanspersModified description
105624view05:00, 10 August 2019KhanspersModified description
96104view09:46, 16 February 2018DeSlRemoved licence number
96103view09:45, 16 February 2018DeSlAdded 2 lit. refs.
96052view16:22, 15 February 2018DeSlModified description
95436view05:40, 15 December 2017MaintBotfixed xref
80206view20:57, 22 May 2015KhanspersReverted to version '16:43, 29 April 2015' by Khanspers
80194view22:54, 19 May 2015Khanspersupdated mirna target interactions
80160view21:03, 14 May 2015Khanspersmir29c targeting added to COL3A1
80158view20:55, 14 May 2015KhanspersAdded mir29c targeting of COL1A1 and COL1A2, general cleanup
79987view16:43, 29 April 2015ZariCorrected Ensembl Id for IGHA2 and IGHA1 gene
63217view21:00, 8 May 2013MaintBotUpdating gpml version
41201view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
38903view20:38, 24 September 2010KhanspersChanged cellular compartments
38889view19:09, 24 September 2010KhanspersChanged line type
38888view19:08, 24 September 2010Khanspers
38222view21:00, 27 August 2010KhanspersChanged CellA to ovals, and changed epithelium from complex to group
34499view22:49, 16 December 2009KhanspersAdded connector
32105view13:46, 14 August 2009MaintBotFixed group labels
21632view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Inflammatory Response Pathway]] moved to [[Pathway:WP453]]: Moved to stable identifier
14707view21:28, 23 May 2008KhanspersAdded connectors
12920view10:40, 17 May 2008MaintBotSticky edges patch by Sjoerd
8206view13:46, 7 January 2008MaintBot[[Pathway:Human:Inflammatory Response Pathway]] moved to [[Pathway:Homo sapiens:Inflammatory Response Pathway]]: Renaming species
7723view16:13, 18 December 2007MaintBotfixed category names
7476view12:42, 4 November 2007MaintBotAdded categories to GPML
6343view22:18, 22 May 2007N.Fidelmangpml file for [[Human:Inflammatory_Response_Pathway]]

External references


View all...
NameTypeDatabase referenceComment
CD28GeneProduct940 (Entrez Gene)
CD40GeneProduct958 (Entrez Gene)
CD40LGGeneProduct959 (Entrez Gene)
CD80GeneProduct941 (Entrez Gene)
CD86GeneProduct942 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL1A2GeneProduct1278 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
IGHA1GeneProductENSG00000211895 (Ensembl)
IGHA2GeneProductENSG00000211890 (Ensembl)
IGHMGeneProduct3507 (Entrez Gene)
IL2GeneProduct3558 (Entrez Gene)
IL2RAGeneProduct3559 (Entrez Gene)
IL2RBGeneProduct3560 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene)
IL4GeneProduct3565 (Entrez Gene)
IL4RGeneProduct3566 (Entrez Gene)
IL5GeneProduct3567 (Entrez Gene)
IL5RAGeneProduct3568 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
LAMC1GeneProduct3915 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene)
THBS3GeneProduct7059 (Entrez Gene)
TNFRSF1AGeneProduct7132 (Entrez Gene)
TNFRSF1BGeneProduct7133 (Entrez Gene)
VTNGeneProduct7448 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)

Annotated Interactions

No annotated interactions

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