IL-2 Signaling Pathway (Mus musculus)

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DPhosphorylationCYCY -> PMPhosphorylationActivationDDAcetylationEndoplasmic reticulumSumoylationGene SymbolCY -> NUMolecular associationDENPlasma membraneMethylationGODMTProteins in a complex interactionGlycosylationERProteolytic cleavageTranslocationDeubiquitinationMolecule in the pathwayUbiquitinationDesumoylationNucleusGolgi apparatusCY -> NU(Protein-protein interaction)CY -> NUPM -> CYCY -> NUDNUPMControlDDDDeacetylationReceptorDAccession Number: NetPath 14CY -> NULigandDephosphorylationInhibitionPalmitolyationMitochondrionEnzyme complexCytoplasmDemethylationExtracellularRecruitmentCY -> NUCY -> NUDAutophosphorylationCY -> NUEndosomeDReactions through unknown mechanisms/moleculesECStat3Pik3r1LynCblGrb2RelaCd53TertPtk2bIl2rbMapkapk2RelaIcam1Jak3Eif3bHsp90aa1Pik3cgNfkb1Raf1NmiTertIl2raItm2bNfkb1Mapk3Ets2Pik3caJak2Ybx1Gab2Mapk1Pik3r2Mapk1Irs1Mapk3ChukPrkczFynBcl2Il2Map2k2KrasIl2Foxo3StamStat5aSos1Ybx1ShbPik3cbStam2CrkCrklSocs3Nr3c1Stat5aIl2rgPtpn11Stat5bIfna1Mknk1SykCishAkt1Shc1Mapk14Ets1Ptpn6Pik3cdMtorLckVav1Jak1Eif4eCrkIl2Gnb2l1Stat1Plcb1Il2Raf1Socs1Mapk9Creb1Map2k1Stat5bAkt1Irs2Il2Mapk8Rps6kb1Akt1


IL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions related to B cell proliferation, and cytolytic activity of natural killer cells. IL-2 also activates lymphokine activated killer cells. In contrast to its proliferative effects, IL-2 also has potent activity in a process known as activation-induced cell death. More recently, IL-2 was shown to promote tolerance through its effects on regulatory T cell development. IL-2 clinically has anti-cancer effects as well as utility in supporting T cell numbers in HIV/AIDS. There are three classes of IL-2 receptors, binding IL-2 with low, intermediate, or high-affinity. The low affinity receptor (IL-2Rα alone) is not functional; signaling by IL-2 involves either the high affinity hetero-trimeric receptor containing IL-2Rα, IL-2Rβ and the common cytokine receptor gamma chain (originally named IL-2Rγ and now generally denoted as γc) or the intermediate affinity heterodimeric receptor composed of IL-2Rβ and γc. IL-2 stimulation induces the activation of the Janus family tyrosine kinases JAK1 and JAK3, which associate with IL-2Rβ and γc, respectively. These kinases in turn phosphorylate IL-2Rβ and induce tyrosine phosphorylation of STATs (signal transducers and activators of transcription) and various other downstream targets. The downstream signaling pathways activated by IL-2 also involves mitogen-activated protein kinase and phosphoinositide 3-kinase signaling modules, leading to both mitogenic and anti-apoptotic signals. Please access this pathway at NetSlim database. NetPath is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, you must cite the NetPath website until the pathway is published.


This pathway was inferred from Homo sapiens pathway WP49(r20779) with a 97% conversion rate.

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89849view12:16, 6 October 2016Mkutmonremove GenMAPP notes
89845view12:16, 6 October 2016MkutmonModified description
83940view23:41, 4 January 2016MaintBotfixed legend
67368view10:43, 26 June 2013Christine ChichesterOntology Term : 'interleukin-2 signaling pathway' added !
41330view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35780view06:18, 13 February 2010MaintBotAdded description
32691view23:07, 31 August 2009Khanspersadded xrefs
31456view21:13, 13 August 2009MaintBotFixed text labels
30817view23:56, 29 July 2009MaintBotConverted from Homo sapiens
21626view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:IL-2 NetPath 14]] moved to [[Pathway:WP450]]: Moved to stable identifier
8166view13:46, 7 January 2008MaintBot[[Pathway:Mouse:IL-2 NetPath 14]] moved to [[Pathway:Mus musculus:IL-2 NetPath 14]]: Renaming species
7703view16:11, 18 December 2007MaintBotfixed category names
7242view12:41, 4 November 2007MaintBotAdded categories to GPML
6459view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:IL-2_NetPath_14]]

External references


View all...
NameTypeDatabase referenceComment
Akt1GeneProduct11651 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
CblGeneProduct12402 (Entrez Gene)
Cd53GeneProduct12508 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
CishGeneProduct12700 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
CrklGeneProduct12929 (Entrez Gene)
Eif3bGeneProduct27979 (Entrez Gene)
Eif4eGeneProduct13684 (Entrez Gene)
Ets1GeneProduct23871 (Entrez Gene)
Ets2GeneProduct23872 (Entrez Gene)
Foxo3GeneProduct56484 (Entrez Gene)
FynGeneProduct14360 (Entrez Gene)
Gab2GeneProduct14389 (Entrez Gene)
Gnb2l1GeneProduct14694 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Hsp90aa1GeneProduct15519 (Entrez Gene)
Icam1GeneProduct15894 (Entrez Gene)
Ifna1GeneProduct15962 (Entrez Gene)
Il2GeneProduct16183 (Entrez Gene)
Il2raGeneProduct16184 (Entrez Gene)
Il2rbGeneProduct16185 (Entrez Gene)
Il2rgGeneProduct16186 (Entrez Gene)
Irs1GeneProduct16367 (Entrez Gene)
Irs2GeneProduct384783 (Entrez Gene)
Itm2bGeneProduct16432 (Entrez Gene)
Jak1GeneProduct16451 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
Jak3GeneProduct16453 (Entrez Gene)
KrasGeneProduct16653 (Entrez Gene)
LckGeneProduct16818 (Entrez Gene)
LynGeneProduct17096 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
Mapkapk2GeneProduct17164 (Entrez Gene)
Mknk1GeneProduct17346 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
NmiGeneProduct64685 (Entrez Gene)
Nr3c1GeneProduct14815 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Plcb1GeneProduct18795 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Ptk2bGeneProduct19229 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Ptpn6GeneProduct15170 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
Rps6kb1GeneProduct72508 (Entrez Gene)
ShbGeneProduct230126 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Socs1GeneProduct12703 (Entrez Gene)
Socs3GeneProduct12702 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
StamGeneProduct20844 (Entrez Gene)
Stam2GeneProduct56324 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Stat5aGeneProduct20850 (Entrez Gene)
Stat5bGeneProduct20851 (Entrez Gene)
SykGeneProduct20963 (Entrez Gene)
TertGeneProduct21752 (Entrez Gene)
Vav1GeneProduct22324 (Entrez Gene)
Ybx1GeneProduct22608 (Entrez Gene)

Annotated Interactions

No annotated interactions
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