G1 to S cell cycle control (Homo sapiens)

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1NucleusG1/S transition PhaseG1 CyclinDependant CyclasesG2 Phase-M phaseCyclin Dsorigin recognition complexG1/S transition CyclinDependent KinasesCyclin EsCell cycle DNA replication genesDNA replicationS phase progressionG1/S Cell CycleCheckpointDNA polymerasesG1 PhaseCCND3POLE2CDKN1BMCM6RB1PCNACDKN2CPRIM2ACDKN1ACREB3L4CDC45LCREB1CCND2TP53ORC4LMCM2POLEE2F1MNAT1ORC5LCCNE2MDM2CDK4MCM5CDK7CCNHCCNE1RPA2CDK7CDK1ATMTP53CREB3CDKN1CORC3LCCND1CDC2ACDK2CCNE1TFDP2MCM3E2F3CCNG2RPA3ORC6LCDK4CCNE1TFDP1CDC25ACDKN2ACCNB1CREB3L3MCM4CREBL1MYT1MCM7CDKN2BPRIM1ORC1LCDKN2DORC2LWEE1POLA2CCNA1Ubiquitin-mediatedproteasome degradationMYCCDK6CDK2CREB3L1RPA1CDK2E2F2GADD45ACDK6PPPUbPCCND1CDK4CDK6CCND1CDK4CDK6RB1E2F2PE2F1E2F3TFDP2TFDP1CDKN1BP


In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC


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106424view22:02, 28 August 2019KhanspersModified description
105450view05:01, 8 August 2019KhanspersModified description
105449view04:59, 8 August 2019KhanspersModified description
105242view22:50, 23 July 2019Khansperswork in progress
105241view22:45, 23 July 2019Khansperswork in progress
105240view22:40, 23 July 2019Khansperswork in progress
105239view20:54, 23 July 2019KhanspersUpdated layout
102300view20:48, 17 December 2018Khanspersremoved GenMAPP comment
97000view22:11, 25 April 2018Khanspersadded phosphosites, general cleanup
95145view03:02, 17 November 2017AlexanderPicoconnected interactions
95124view15:09, 16 November 2017DeSlFixed nested groups
94764view16:01, 5 October 2017Ryanmillerconnected lines
80001view08:36, 30 April 2015Zarichanged Box for CyclinD an CdK , annotated CDC2A gene
80000view08:21, 30 April 2015ZariChanged box for CyclinD and CdK
71377view18:39, 17 October 2013MaintBotAutomated update of data sources
67270view10:29, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
63189view20:50, 8 May 2013MaintBotUpdating gpml version
45301view19:58, 7 October 2011AlexanderPicoOntology Term : 'cell cycle checkpoint pathway' added !
41128view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
38746view22:18, 23 September 2010Mark.scottccna1 link
38745view22:17, 23 September 2010Mark.scottconnect cdk1
35815view19:02, 17 February 2010KhanspersModified description
35814view18:36, 17 February 2010KhanspersAdded lit ref
32435view17:14, 15 August 2009MaintBotFixed text labels
32104view13:46, 14 August 2009MaintBotFixed group labels
20771view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:WP45]]: Moved to stable identifier
15393view22:27, 27 May 2008Khanspersconnectors
14438view22:42, 22 May 2008KhanspersAdded connectors, groups
14433view22:33, 22 May 2008KhanspersPeriodical save, work in progress
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12942view10:43, 17 May 2008MaintBotSticky edges patch by Sjoerd
7944view13:46, 7 January 2008MaintBot[[Pathway:Human:Cell Cycle-G1 to S control Reactome]] moved to [[Pathway:Homo sapiens:Cell Cycle-G1 to S control Reactome]]: Renaming species
7597view16:03, 18 December 2007MaintBotfixed category names
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6300view22:17, 22 May 2007A.C.Zambongpml file for [[Human:Cell_Cycle-G1_to_S_control_Reactome]]

External references


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NameTypeDatabase referenceComment
ATMGeneProduct472 (Entrez Gene)
CCNA1GeneProduct8900 (Entrez Gene)
CCNB1GeneProduct891 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCNE2GeneProduct9134 (Entrez Gene)
CCNG2GeneProduct901 (Entrez Gene)
CCNHGeneProduct902 (Entrez Gene)
CDC25AGeneProduct993 (Entrez Gene)
CDC2AGeneProduct1017 (Entrez Gene)
CDC45LGeneProduct8318 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CDKN1CGeneProduct1028 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CDKN2BGeneProduct1030 (Entrez Gene)
CDKN2CGeneProduct1031 (Entrez Gene)
CDKN2DGeneProduct1032 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CREB3GeneProduct10488 (Entrez Gene)
CREB3L1GeneProduct90993 (Entrez Gene)
CREB3L3GeneProduct84699 (Entrez Gene)
CREB3L4GeneProduct148327 (Entrez Gene)
CREBL1GeneProduct1388 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
E2F2GeneProduct1870 (Entrez Gene)
E2F3GeneProduct1871 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
MCM2GeneProduct4171 (Entrez Gene)
MCM3GeneProduct4172 (Entrez Gene)
MCM4GeneProduct4173 (Entrez Gene)
MCM5GeneProduct4174 (Entrez Gene)
MCM6GeneProduct4175 (Entrez Gene)
MCM7GeneProduct4176 (Entrez Gene)
MDM2GeneProduct4193 (Entrez Gene)
MNAT1GeneProduct4331 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
MYT1GeneProduct4661 (Entrez Gene)
ORC1LGeneProduct4998 (Entrez Gene)
ORC2LGeneProduct4999 (Entrez Gene)
ORC3LGeneProduct23595 (Entrez Gene)
ORC4LGeneProduct5000 (Entrez Gene)
ORC5LGeneProduct5001 (Entrez Gene)
ORC6LGeneProduct23594 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
POLA2GeneProduct23649 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLEGeneProduct5426 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRIM2AGeneProduct5558 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RPA1GeneProduct6117 (Entrez Gene)
RPA2GeneProduct6118 (Entrez Gene)
RPA3GeneProduct6119 (Entrez Gene)
TFDP1GeneProduct7027 (Entrez Gene)
TFDP2GeneProduct7029 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
Ubiquitin-mediated proteasome degradationPathwayWP183 (WikiPathways)
WEE1GeneProduct7465 (Entrez Gene)

Annotated Interactions

No annotated interactions

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