Signal transduction through IL1R (Homo sapiens)

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Signal transduction through IL1R.

Pathway based on Biocarta pathway (M12095).

IL-1 signals primarily through the IL-1 receptor type 1 (IL-1R1). Through expression of cytokines such as TNF, TGF-beta and interferons, IL-1 holds a range of inflammatory activities that include induction of fever, expression of vascular adhesion molecules and roles in arthritis and septic shock. IL-1 binds to the respective IL-1 receptor however, it requires the IL-1 receptor accessory protein (IL-1RAP) to transduce a signal. Two kinases (IRAK-1 and IRAK-2) get activated through IL-1 binding to its receptor. Via these kinases a cascade gets activated which includes TRAF6, NF-kB activation and c-JUN activation. The IL-1 signaling cascade represents a highly conserved response to pathogens.

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Ontology Terms



  1. O'Neill LA, Greene C; ''Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.''; J Leukoc Biol, 1998 PubMed Europe PMC Scholia
  2. Cargnello M, Roux PP; ''Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.''; Microbiol Mol Biol Rev, 2011 PubMed Europe PMC Scholia


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102693view15:43, 19 January 2019FehrhartOntology Term : 'signaling pathway' added !
102663view12:48, 16 January 2019LaurentModified description
102656view10:04, 16 January 2019LaurentAdded references
102647view09:01, 16 January 2019LaurentFixed interactions
102622view15:10, 14 January 2019LaurentNew pathway

External references


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NameTypeDatabase referenceComment
CHUKGeneProduct1147 (Entrez Gene)
ECSITGeneProduct51295 (Entrez Gene)
IFNA1GeneProduct3439 (Entrez Gene)
IFNB1GeneProduct3456 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1R1GeneProduct3554 (Entrez Gene)
IL1RAPGeneProduct3556 (Entrez Gene)
IL1RNGeneProduct3557 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IRAK1GeneProduct3654 (Entrez Gene)
IRAK2GeneProduct3656 (Entrez Gene)
IRAK3GeneProduct11213 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
MAP2K3GeneProduct5606 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MYD88GeneProduct4615 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
TAB1GeneProduct10454 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TOLLIPGeneProduct54472 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)

Annotated Interactions

No annotated interactions

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