IL-10 Anti-inflammatory Signaling Pathway (Homo sapiens)

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1, 2LPS induced pathwayDNA+Macrophage cytoplasmInflammatory cytokinegenesJAK/STAT inducedgenesNucleusBiliverdinIL10RAIL1ATNFIL10BLVRBHemeSTAT1HMOX1IL10RBCOBLVRAp38 MAPK pathwaySTAT3JAK1BilirubinSTAT2IL6HMOX1DNA


Description

IL-10 Anti-inflammatory Signaling Pathway.

Pathway based on Biocarta pathway (M6778). https://cgap.nci.nih.gov/Pathways/BioCarta/h_il10Pathway

IL-10 binds to its respective IL-10 receptor which activates the JAK/STAT pathway and MAPK pathway involving the p38 kinases. This leads to the induction of the enzyme heme oxygenase-1 (HMOX1) which is involved in the biosynthesis of heme, and catalyzes the reaction producing the heme precursor biliverdin. The ani-inflammatory actions of HMOX appear to be the result of signaling by carbon monoxide which inhibits pro-inflammatory cytokine production.

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Ontology Terms

 

Bibliography

  1. Hutchins AP, Diez D, Miranda-Saavedra D; ''The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges.''; Brief Funct Genomics, 2013 PubMed Europe PMC Scholia
  2. Verma R, Balakrishnan L, Sharma K, Khan AA, Advani J, Gowda H, Tripathy SP, Suar M, Pandey A, Gandotra S, Prasad TS, Shankar S; ''A network map of Interleukin-10 signaling pathway.''; J Cell Commun Signal, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
102692view15:42, 19 January 2019FehrhartOntology Term : 'signaling pathway' added !
102664view12:53, 16 January 2019LaurentModified description
102649view09:19, 16 January 2019LaurentUpdated literature
102648view09:12, 16 January 2019LaurentAdded metabolite and pathway nodes. Fixed interactions
102621view13:54, 14 January 2019LaurentNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BLVRAGeneProduct644 (Entrez Gene)
BLVRBGeneProduct645 (Entrez Gene)
BilirubinMetaboliteQ104219 (Wikidata)
BiliverdinMetaboliteQ422964 (Wikidata)
COMetaboliteQ2025 (Wikidata)
HMOX1GeneProduct3162 (Entrez Gene)
HemeMetaboliteQ189621 (Wikidata)
IL10GeneProduct3586 (Entrez Gene)
IL10RAGeneProduct3587 (Entrez Gene)
IL10RBGeneProduct3588 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TNFGeneProduct7214 (Entrez Gene)
p38 MAPK pathwayPathwayWP400 (WikiPathways)

Annotated Interactions

No annotated interactions

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