Cells and Molecules involved in local acute inflammatory response (Homo sapiens)

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1-3PlasminChemokinesEndothelial damageBLOODFibrinFribinopeptidesProstaglandinsTissue damageLymphocyteBacteriaMast cellLeukotrienesAlternative orClassical pathwayNeutophilChemotaxisActivated macrophageHistamineMonocyteKNG1TNFComplement activationC7IL8IL6C6C3C5IL1ALeukotrienesProstaglandinsSELPLGSELPNeutophilICAM1ITGALITGB2LymphocyteMonocyteC5C3VCAM1ITGB1ITGA4


Cells and Molecules involved in local acute inflammatory response.

Pathway based on Biocarta pathway (M3952) https://cgap.nci.nih.gov/Pathways/BioCarta/h_LairPathway

Tissue damage induces the release of inflammatory signaling molecules. Additionally, bacterial infection stimulates an immune response. Bacterial infection can activate macrophages and induce the release of pro-inflammatory cytokines such as TNF, IL-6 and IL-1. Both tissue damage and bacterial infection can induce complement activation, either via the alternative or classical pathway. Leukocytes can be attracted via pro-inflammatory cytokines and chemokines released by mast cells and activated macrophages. Leukocytes can also induce complement activation. The combined response can result in a more permeable endothelium of blood vessels, induce swelling and activate immune cells.

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Ontology Terms



  1. Noris M, Remuzzi G; ''Overview of complement activation and regulation.''; Semin Nephrol, 2013 PubMed Europe PMC Scholia
  2. Blüml S, Redlich K, Smolen JS; ''Mechanisms of tissue damage in arthritis.''; Semin Immunopathol, 2014 PubMed Europe PMC Scholia
  3. Sherwood ER, Toliver-Kinsky T; ''Mechanisms of the inflammatory response.''; Best Pract Res Clin Anaesthesiol, 2004 PubMed Europe PMC Scholia


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102660view10:54, 16 January 2019LaurentModified description
102659view10:53, 16 January 2019LaurentUpdated references. Added pathway node
102658view10:36, 16 January 2019LaurentAdded references
102646view08:59, 16 January 2019LaurentFixed interactions
102619view10:34, 14 January 2019LaurentUpdated description
102618view10:32, 14 January 2019LaurentNew pathway

External references


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NameTypeDatabase referenceComment
C3GeneProduct718 (Entrez Gene)
C5GeneProduct727 (Entrez Gene)
C6GeneProduct729 (Entrez Gene)
C7GeneProduct730 (Entrez Gene)
Complement activationPathwayWP545 (WikiPathways)
ICAM1GeneProduct3383 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
ITGA4GeneProduct3676 (Entrez Gene)
ITGALGeneProduct3683 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
ITGB2GeneProduct3689 (Entrez Gene)
KNG1GeneProduct3827 (Entrez Gene)
SELPGeneProduct6403 (Entrez Gene)
SELPLGGeneProduct6404 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
VCAM1GeneProduct7412 (Entrez Gene)

Annotated Interactions

No annotated interactions

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