Role of Altered Glycolysation of MUC1 in Tumour Microenvironment (Homo sapiens)

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1, 2CytosolNucleusCytokine TranscriptionT-cellsRecruitment inflammatory cellsIkKBTNFIkKAIkKGIkBARELAIL6MUC1NFkB1NFkB1RELAMUC1RELANFkB1DCMacrophageIkBAPDNA


Altered MUC1 glycosylation extends to its role as a promoter of chronic inflammatory conditions that lead to malignant transformation and cancer progression.

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  1. Cascio S, Finn OJ; ''Intra- and Extra-Cellular Events Related to Altered Glycosylation of MUC1 Promote Chronic Inflammation, Tumor Progression, Invasion, and Metastasis.''; Biomolecules, 2016 PubMed Europe PMC Scholia
  2. Gilmore TD; ''Introduction to NF-kappaB: players, pathways, perspectives.''; Oncogene, 2006 PubMed Europe PMC Scholia


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107458view17:41, 10 October 2019KhanspersModified title
102530view01:31, 4 January 2019Khanspersconnected interactions
102254view10:46, 13 December 2018LaurentVisual aspects
102245view14:04, 12 December 2018LaurentVisual aspects
102239view13:11, 12 December 2018LaurentChanged typos
102238view13:08, 12 December 2018LaurentNew pathway

External references


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NameTypeDatabase referenceComment
IL6GeneProduct3569 (Entrez Gene)
IkBAGeneProduct4792 (Entrez Gene)
IkKAGeneProduct1147 (Entrez Gene)
IkKBGeneProduct8517 (Entrez Gene)
IkKGGeneProduct3551 (Entrez Gene)
MUC1GeneProduct4582 (Entrez Gene)
NFkB1GeneProduct4790 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)

Annotated Interactions

No annotated interactions

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