LTF danger signal response pathway (Homo sapiens)

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1CytosolTrauma or InfectionNucleusDNATLR4IFNAIL6TNFIFNBCD14IL8RAGEIL1AIRAK1LTFIL1BTRAF6MAPK1TREM1IRAK4TLR2NFkBMYD88


Description

Lactoferrin (LTF) activates NF-kB via danger signal receptors TLR2/4 and CD14. LTF may also activate NF-kB via addiotnal receptors RAGE and TREM1.

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Bibliography

  1. Kruzel ML, Zimecki M, Actor JK; ''Lactoferrin in a Context of Inflammation-Induced Pathology.''; Front Immunol, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
103756view23:29, 3 April 2019KhanspersModified description
103754view23:15, 3 April 2019Khanspersfixed unconnected interactions
102252view10:39, 13 December 2018LaurentVisual aspects
102242view13:29, 12 December 2018LaurentUpdated visual aspects
102241view13:22, 12 December 2018LaurentChanged visual aspects
102237view12:31, 12 December 2018LaurentModified description
102232view09:44, 12 December 2018LaurentName NFkB fixed
102231view09:43, 12 December 2018Laurenttypo in entrezgene ID NFkB fixed
102230view09:13, 12 December 2018LaurentModified title
102229view09:08, 12 December 2018LaurentNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CD14GeneProduct929 (Entrez Gene)
IFNAGeneProduct3439 (Entrez Gene)
IFNBGeneProduct3456 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
IRAK1GeneProduct3654 (Entrez Gene)
IRAK4GeneProduct51135 (Entrez Gene)
LTFGeneProduct4057 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MYD88GeneProduct4615 (Entrez Gene)
NFkBGeneProduct4790 (Entrez Gene)
RAGEGeneProduct177 (Entrez Gene)
TLR2GeneProduct7097 (Entrez Gene)
TLR4GeneProduct7099 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
TREM1GeneProduct54210 (Entrez Gene)

Annotated Interactions

No annotated interactions

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