SUMOylation of SUMOylation proteins (Homo sapiens)

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14156, 10, 121383, 6nucleoplasmTOPORSNUP88 SUMO2-C93-UBE2I NUP35 NUP160 UBE2I-G97-SUMO1 UBE2I-G97-SUMO1 NUP62 Nup45 SUMO1:C93-UBE2ITOPORS-G97-SUMO1 SUMO1-K14-UBE2I NUPL1-2 SUMO1-C93-UBE2I NUP188 K2650-RANBP2-G97-SUMO1 SEH1L-2 TPR UBE2INUP50 NUP37 NUP153 PIAS4SUMO1:K14-UBE2IRAE1 NUP43 UBE2INUP93 UBE2I-G97-SUMO1 POM121 UBE2ISUMO1:TOPORSUBE2ISUMO1-C93-UBE2I SUMO1:C93-UBE2ISUMO1-C93-UBE2I SUMO1:PIAS4NUP210 K14-UBE2I-G97-SUMO1 SUMO1-C93-UBE2I UBE2IK2592-RANBP2-G97-SUMO1 NUP133 SUMO1:C93-UBE2IUBE2I-G97-SUMO1 SUMO1-K35-PIAS4 NUP85 RANBP2 AAAS NUP98-5 NUP54 SUMO1-K2592,K2650,K2723-RANBP2 NUP107 NDC1 NUP98-4 UBE2I-G93-SUMO2 SUMO2-K2652,K2725-RANBP2Nuclear Pore Complex(NPC)POM121C SUMO2:UBE2ISUMO1-K560-TOPORS NUP98-3 3SUMO1:RANBP2SUMO1:C93-UBE2IPIAS4-G97-SUMO1 NUP214 NUP205 NUP155 RANBP2K2723-RANBP2-G97-SUMO1 NUPL2 815132, 7, 9, 11351, 46, 12


Description

SUMOylation processes themselves can be controlled by SUMOylation (reviewed in Wilkinson and Henley 2010). The SUMO E3 ligases PIAS4, RANBP2, and TOPORS are SUMOylated, as is the single SUMO E2 enzyme, UBE2I (UBC9). SUMOylation affects the subcellular location of PIAS4 and TOPORS and affects the activity of PIAS4 and UBE2I. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 4085377
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: May, Bruce

Quality Tags

Ontology Terms

 

Bibliography

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  1. Su HL, Li SS.; ''Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.''; PubMed Europe PMC
  2. Rabut G, Doye V, Ellenberg J.; ''Mapping the dynamic organization of the nuclear pore complex inside single living cells.''; PubMed Europe PMC
  3. Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC.; ''Uncovering global SUMOylation signaling networks in a site-specific manner.''; PubMed Europe PMC
  4. Kamitani T, Kito K, Nguyen HP, Fukuda-Kamitani T, Yeh ET.; ''Characterization of a second member of the sentrin family of ubiquitin-like proteins.''; PubMed Europe PMC
  5. Fontoura BM, Blobel G, Matunis MJ.; ''A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.''; PubMed Europe PMC
  6. Cooper HJ, Tatham MH, Jaffray E, Heath JK, Lam TT, Marshall AG, Hay RT.; ''Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction.''; PubMed Europe PMC
  7. Suntharalingam M, Wente SR.; ''Peering through the pore: nuclear pore complex structure, assembly, and function.''; PubMed Europe PMC
  8. Weger S, Hammer E, Engstler M.; ''The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation.''; PubMed Europe PMC
  9. Ori A, Banterle N, Iskar M, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.; ''Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.''; PubMed Europe PMC
  10. Pichler A, Gast A, Seeler JS, Dejean A, Melchior F.; ''The nucleoporin RanBP2 has SUMO1 E3 ligase activity.''; PubMed Europe PMC
  11. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ.; ''Proteomic analysis of the mammalian nuclear pore complex.''; PubMed Europe PMC
  12. Pichler A, Knipscheer P, Saitoh H, Sixma TK, Melchior F.; ''The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type.''; PubMed Europe PMC
  13. Ihara M, Yamamoto H, Kikuchi A.; ''SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.''; PubMed Europe PMC
  14. Wilkinson KA, Henley JM.; ''Mechanisms, regulation and consequences of protein SUMOylation.''; PubMed Europe PMC
  15. Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A.; ''Ubc9 sumoylation regulates SUMO target discrimination.''; PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
101676view13:55, 1 November 2018DeSlOntology Term : 'sumoylation pathway' added !
101525view11:39, 1 November 2018ReactomeTeamreactome version 66
101195view21:39, 31 October 2018ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
3SUMO1:RANBP2ComplexR-HSA-4551684 (Reactome)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
K14-UBE2I-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K2592-RANBP2-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K2650-RANBP2-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
K2723-RANBP2-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
NDC1 ProteinQ9BTX1 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188 ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205 ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-3 ProteinP52948-3 (Uniprot-TrEMBL)
NUP98-4 ProteinP52948-4 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL1-2 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
Nuclear Pore Complex (NPC)ComplexR-HSA-157689 (Reactome)
Nup45 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
PIAS4-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
PIAS4ProteinQ8N2W9 (Uniprot-TrEMBL)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
POM121C ProteinA8CG34 (Uniprot-TrEMBL)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
RANBP2ProteinP49792 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SUMO1-C93-UBE2I ProteinP63279 (Uniprot-TrEMBL)
SUMO1-K14-UBE2I ProteinP63279 (Uniprot-TrEMBL)
SUMO1-K2592,K2650,K2723-RANBP2 ProteinP49792 (Uniprot-TrEMBL)
SUMO1-K35-PIAS4 ProteinQ8N2W9 (Uniprot-TrEMBL)
SUMO1-K560-TOPORS ProteinQ9NS56 (Uniprot-TrEMBL)
SUMO1:C93-UBE2IComplexR-HSA-2993783 (Reactome)
SUMO1:K14-UBE2IComplexR-HSA-4085346 (Reactome)
SUMO1:PIAS4ComplexR-HSA-3968369 (Reactome)
SUMO1:TOPORSComplexR-HSA-4551716 (Reactome)
SUMO2-C93-UBE2I ProteinP63279 (Uniprot-TrEMBL)
SUMO2-K2652,K2725-RANBP2ProteinP49792 (Uniprot-TrEMBL)
SUMO2:UBE2IComplexR-HSA-2993778 (Reactome)
TOPORS-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
TOPORSProteinQ9NS56 (Uniprot-TrEMBL)
TPR ProteinP12270 (Uniprot-TrEMBL)
UBE2I-G93-SUMO2 ProteinP61956 (Uniprot-TrEMBL)
UBE2I-G97-SUMO1 ProteinP63165 (Uniprot-TrEMBL)
UBE2IProteinP63279 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
3SUMO1:RANBP2ArrowR-HSA-4551649 (Reactome)
Nuclear Pore Complex (NPC)mim-catalysisR-HSA-4551649 (Reactome)
Nuclear Pore Complex (NPC)mim-catalysisR-HSA-4551679 (Reactome)
PIAS4R-HSA-3968362 (Reactome)
R-HSA-3968362 (Reactome) PIAS4 is SUMOylated at lysine-35 with SUMO1 (Ihara et al. 2005). SUMOylation of PIAS4 at lysine-35 decreases its localization with PML. SUMOylated PIAS4 is able to increase SUMOylation and transcriptional activity of TCF4.
R-HSA-4085350 (Reactome) UBE2I (UBC9) is SUMOylated at lysine-14 with SUMO1 (Knipscheer et al. 2008). SUMOylation alters the target specificity of UBE2I, decreasing its SUMOylation activity towards RanGAP1 and increasing it towards SP100.
R-HSA-4551649 (Reactome) RANBP2 SUMOylates RANBP2 at lysine-2592, lysine-2650, and lysine-2723 with SUMO1 (Pichler et al. 2002, Pichler et al. 2004, Cooper et al. 2005). RANBP2 does not resemble HECT or RING type SUMO E3 ligases and instead uses hydrophobic interactions with UBE2I (UBC9) to catalyze SUMOylation.
R-HSA-4551679 (Reactome) RANBP2 SUMOylates RANBP2 at lysine-2652 and lysine-2725 with SUMO2 (Cooper et al. 2005, Hendriks et al. 2014).
R-HSA-4551683 (Reactome) TOPORS is SUMOylated at lysine-560 with SUMO1 (Weger et al. 2003).
RANBP2R-HSA-4551649 (Reactome)
RANBP2R-HSA-4551679 (Reactome)
SUMO1:C93-UBE2IR-HSA-3968362 (Reactome)
SUMO1:C93-UBE2IR-HSA-4085350 (Reactome)
SUMO1:C93-UBE2IR-HSA-4551649 (Reactome)
SUMO1:C93-UBE2IR-HSA-4551683 (Reactome)
SUMO1:C93-UBE2Imim-catalysisR-HSA-3968362 (Reactome)
SUMO1:C93-UBE2Imim-catalysisR-HSA-4085350 (Reactome)
SUMO1:C93-UBE2Imim-catalysisR-HSA-4551683 (Reactome)
SUMO1:K14-UBE2IArrowR-HSA-4085350 (Reactome)
SUMO1:PIAS4ArrowR-HSA-3968362 (Reactome)
SUMO1:TOPORSArrowR-HSA-4551683 (Reactome)
SUMO2-K2652,K2725-RANBP2ArrowR-HSA-4551679 (Reactome)
SUMO2:UBE2IR-HSA-4551679 (Reactome)
TOPORSR-HSA-4551683 (Reactome)
UBE2IArrowR-HSA-3968362 (Reactome)
UBE2IArrowR-HSA-4085350 (Reactome)
UBE2IArrowR-HSA-4551649 (Reactome)
UBE2IArrowR-HSA-4551679 (Reactome)
UBE2IArrowR-HSA-4551683 (Reactome)
UBE2IR-HSA-4085350 (Reactome)
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