Several ubiquitin E3 ligases are regulated by SUMOylation (reviewed in Wilson and Heaton 2008). SUMOylation appears to be necessary for nuclear import of MDM2, the E3 ligase that ubiquitinylates TP53 (p53). SUMOylation of VHL abolishes its ubiquitin ligase activity. HERC2, RNF168, and BRCA1 are ubiquitin ligases that are SUMOylated during DNA damage response and repair.
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Reactome Author: May, Bruce
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Chu Y, Yang X.; ''SUMO E3 ligase activity of TRIM proteins.''; PubMedEurope PMC
Ori A, Banterle N, Iskar M, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.; ''Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.''; PubMedEurope PMC
Wilson VG, Heaton PR.; ''Ubiquitin proteolytic system: focus on SUMO.''; PubMedEurope PMC
Cai Q, Verma SC, Kumar P, Ma M, Robertson ES.; ''Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification.''; PubMedEurope PMC
Chien W, Lee KL, Ding LW, Wuensche P, Kato H, Doan NB, Poellinger L, Said JW, Koeffler HP.; ''PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells.''; PubMedEurope PMC
Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H.; ''Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes.''; PubMedEurope PMC
Suntharalingam M, Wente SR.; ''Peering through the pore: nuclear pore complex structure, assembly, and function.''; PubMedEurope PMC
Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ.; ''Proteomic analysis of the mammalian nuclear pore complex.''; PubMedEurope PMC
Rabut G, Doye V, Ellenberg J.; ''Mapping the dynamic organization of the nuclear pore complex inside single living cells.''; PubMedEurope PMC
Cai Q, Robertson ES.; ''Ubiquitin/SUMO modification regulates VHL protein stability and nucleocytoplasmic localization.''; PubMedEurope PMC
Fontoura BM, Blobel G, Matunis MJ.; ''A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.''; PubMedEurope PMC
PML TRIM27, PIAS1, and PIAS2-1 can each SUMOylate MDM2 with SUMO1 at lysine-182 (Miyauchi et al. 2002, Chu and Yang 2011). An unSUMOylatable mutant of MDM2 accumulates in the cytosol so SUMOylation may be part of the process of nuclear import of MDM2 (Miyauchi et al. 2002).
PIAS4 SUMOylates VHL at lysine-159, lysine-171, and lysine-196 with SUMO1 (Cai et al. 2010, Cai and Robertson 2010, Chien et al. 2013). SUMOylation facilitates the oligomerization of VHL, abolishes the inhibitory function of VHL on HIF1A, and abolishes the tumor suppressor function of VHL by inactivating the ubiquitinylation activity of VHL.
RANBP2 of the nuclear pore complex SUMOylates MDM2 with SUMO1 at lysine-182 (Mayauchi et al. 2002). An unSUMOylatable mutant of MDM2 accumulates in the cytosol so SUMOylation may be part of the process of nuclear import of MDM2 (Miyauchi et al. 2002).
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