ESR-mediated signaling (Homo sapiens)

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ESR1dimer:estrogen:TGFAgene promoterE1 HIST1H2AB H2AFV HIST1H2BN H2AFJ GREB1 gene GREB1 gene HIST2H2AA3 ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300CTSD gene H2AFZ ADPHDAC1H2AFB1 HIST1H2AJ HIST1H2AJ H2AFZ PGR CCND1gene:H3K4me2nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOSHIST1H2BA Me3K-10-H3F3A P4 HIST1H4 GATA3HIST1H2BD HIST1H2AC MYBgene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFbCREBBPHIST1H3A HIST1H2BK HIST1H2BM HIST1H2BB ERBB4jmAcyt2s80 HIST1H2BN HIST1H2BN ESR2 HIST1H2BB RUNX1 CBFB KPNA2 mRNAHIST1H2BA H2AFB1 CARM1NCOA1 ESTG HIST1H2AC CTSDgene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1CBFB PGR HIST1H3A H2AFJ HIST1H2AB GPAM gene HIST2H2BE EP300 CTSD gene HIST1H2BO HIST1H2AJ HIST1H3A HIST1H2AJ miR-26A RISC EBAG9KAT5 HIST1H2BD CXXC5 gene:ESR1:ESTGH2BFS RUNX1:CBFB:ESR1:estrogenTPR-containingco-chaperonesHIST1H2BL 27-hydroxycholesterol:ESR1,2HIST1H4 TFF3ESTG HIST1H3A HIST2H2AA3 27-hydroxycholesterolGREB1 MYC gene miR-26A RISC HIST1H2BM HIST2H2BE H2BFS HIST1H2BD RUNX1 p-T69,T71-ATF2 AXIN1MYB gene HIST1H2BH ESTG ESR1 HIST1H2BL HIST1H4 HIST1H4 ESTG CCND1 gene MYCgene,BCL2gene:HIST1H2ACnucleosome:ESR1:ESTGMYB gene CITED1 ESTG HIST1H2AD HIST1H4 CDK9 JUND H2AFJ GTF2F2 HIST1H2BH HIST3H2BB HIST1H2BJ ERBB4s80:ESR1:estrogenH2BFS ESR1 27-hydroxycholesterol SP1HIST1H2BO H2AFZ MYC geneKDM4B-regulatedgenes:H3K9me3nucleosome:ESR1:ESTG:KDM4BHIST1H2BJ PTGES3 MYB gene PTGES3 H2AFJ BCL2 gene NR5A2 TGFA GeneCREBBP KANK1MYC gene HIST1H2BC CTSD geneCHD1 mRNA:mIR-26RISCSMC1A HIST1H2BC ATP H2AFZ ESR1 MYC POLR2E HSP90AA1 TFF1HIST1H2BN HIST1H2BB HSP90AA1 KCTD6ESTG HIST1H2BL p-T185,Y187-MAPK1 HIST1H2AJ KDM1A ESTG HSP-90HIST2H2BE HIST1H2BO H2AFJ GTF2F1 H2AFV TFF3gene:FOXA1:GATA3:ESR1:ESTG:EP300CCND1 gene ADPp-T69,T71-ATF2 NRIP1CCND1gene:H3K4me2nucleosome:FOXA1:GATA3H2BFS estriol HIST1H2BN KPNA2 mRNA:mIR-26RISCH2AFJ HIST1H2AD H2AFZ H2BFS H3F3A POLR2F PTGES3 HIST2H2AC H2AFB1 KDM4B NCOA1 ESR1 HIST1H2BA H2AFX POLR2I HIST1H4 ESR2 GATA3 HIST1H2BC HIST3H2BB HIST1H2BC KPNA2 mRNA ESR1 HIST1H2AD estriol HIST1H2BJ RUNX1 H2AFZ ESTG USF1 HIST1H2BO HIST1H2BA HIST1H2AJ GTF2A2 POLR2L MYB gene HSP90AB1 FKBP5 HIST1H2AD MYCgene:ESR1:ESTG:JUND:FOSB:Cohesin ComplexKPNA2HIST1H2BH AXIN1 gene HIST2H3A HIST1H2BA HIST1H2BC RUNX1:CBFBHIST3H2BB HIST1H2BH HIST1H2AB HDAC1 HIST1H2AC HSP90AA1 ESTG HSP90AB1 HIST1H2BL HIST1H2BM BCL2 gene ESR1 RUNX1:CBFB:ESR1:estrogen:GPAM genep-S5-POLR2A HIST2H2AA3 ESR1:chaperonecomplexHIST2H2BE KAT2B HIST1H2AD HIST1H2BJ HIST1H2BA HIST1H2AC H2AFZ EP300 HIST1H2BC ESTG PGR HIST1H2BH HIST1H2BD HIST1H2BN HIST1H2BL GATA3 MYCgene:nucleoplasm:ESR1:ESTGCCND1 gene H2AFV POLR2D H2AFB1 HIST1H2BK HIST2H2AC H2AFB1 HIST3H2BB HIST1H2BJ HIST1H2BM HIST1H2AC GPAM(1-828)ESTG HIST3H2BB GREB1 mRNA:miR-26RISCHIST1H2BB HIST1H2AC HIST1H2BB Me3K-10-HIST1H3A FOSB:JUNDEP300 YY1ESR1 CCNT1 CITED1:EP300:ESR1:estrogen:TGFA gene promoterH2AFJ HIST1H2BH HIST1H2BD CBFB HIST1H2AJ P4 HIST1H2BN ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1H2AFX HIST1H2AC ESTG HIST3H2BB ESTGSTAG1 miR-26A RISC JUN H2AFV HIST1H2BK HIST1H2AC KDM4B gene HIST1H2BN CXXC5 geneGATA3 HIST1H2BC ESR1 POLR2J ESTG HIST2H2AA3 HIST1H2BN estriol EP300 ESR1 HIST2H2AA3 ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATsH2AFV ESTG POLR2G HIST1H2AC POLR2E ESTG HIST1H2BL HIST2H2AC BCL2FOXA1 ESTG:ESRs:chaperonecomplexHIST1H2BD HIST1H2BO JUN H2AFV HIST1H2BM HIST2H3A FKBP5 ERBB4jmAcyt2s80 HIST1H2BD HIST2H2BE HIST1H2BD EP300 HIST2H2BE EP300 HIST1H3A p-T,Y MAPK dimersHIST1H2BJ HIST1H2BK ESTGHIST2H2BE POLR2C TFF3 gene TFF1 gene TLE3 ESR2 EP300 KDM4B gene HIST2H2AA3 HSP90AB1 RAD21 HIST1H4 CCND1gene:H3K4me2nucleosome:YY1:HDAC1HIST1H2BD HIST1H2BM HIST1H2BJ HIST1H2AB HIST1H2BA Transcriptionalregulation by RUNX1MED1 GTF2A1(1-274) GATA3 HIST1H4 Me3K-10-H3F3A NCOA3 USF2 ZNF217 Me2K5-H3F3A BCL2 gene miR-26B RISC ESR1 H3F3A ESTG HIST1H2BH FOXA1 HIST1H2AD HIST1H4 HIST1H2BM DDX5 HIST1H2AJ ESTG HIST1H2BO HIST1H2BC GREB1 geneCBFB RUNX1:CBFB:ESR1:estrogen:KCTD6 geneHIST1H2BH CHD1HIST1H2BC ESR2 HIST3H2BB HIST1H2AC NCOA1,NCOA3 GTF2F2 HIST1H2BC HIST1H2BB H2AFZ HIST1H2BK TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3MYB gene POLR2F KAT5 miR-26B RISC HIST1H4 H2AFB1 SMC3 ESTG HIST1H2BN HIST1H2BL H2AFZ FKBP4HIST2H2BE STAG1 HIST1H2BB HIST3H2BB ESR1 H2AFJ ESTG HIST1H2BK ESTG USF1ATPH2AFX FOSB HIST2H2AC HIST1H2BA FOXA1ESTG ESR1 HIST2H2BE HIST1H2BJ CCND1 gene NCOA1,NCOA3 GREB1 mRNAHIST1H2AC ESR1 PTGES3KPNA2 geneESR1 CXXC5 gene POLR2L NCOA1HIST2H3A HIST1H2BA HIST3H2BB KDM4B gene H2AFZ HIST1H2BM STAG2 H2AFX HIST1H2BC PGRHIST1H2BB H2BFS H2AFV Me2K10-HIST1H3A HIST2H2BE MYC gene HIST1H2AD TGFA precursorHIST1H2BB GATA3 HIST1H2BD ESR1 GPAM geneFOXA1 FOXA1 POLR2J PiPPID HIST1H2BM HIST1H2BO POU2F1ESR1,2:ESTGESR1 H2AFB1 TFF3 gene MYBgene:hypophosphorylated RNA polymerase II:TFIIFYY1 ESR1:estrogen:AXIN1geneESR1:ESTG:P-TEFbHIST1H2BA ESR1 dimer:estrogenHIST1H2AJ KDM4B gene HIST1H2BA ERBB4jmAcyt2s80 ERBB4jmAcyt1s80 HIST1H2BH FOS POLR2F HIST2H3A HIST1H2BC HIST2H3A TFF3 gene HIST1H2BK ESTG JUND GTF2F1 HSP90AB1 ESR1,2HIST2H3A HIST2H3A EP300 HSP90:HSP90ERBB4jmAcyt1s80 POLR2B H2AFJ Me2K5-HIST2H3A H2AFB1 p-S5-POLR2A ESR1 HIST2H2AC POLR2B HIST1H4 CXCL12(22-93)ESTG Me2K5-HIST1H3A ESR1 FKBP4 ERBB4jmAcyt2s80 POLR2H EST17b NCOA3 HIST1H2AB HIST1H2ACESR2 SP1 HIST1H2BC Me2K5-HIST2H3A Me2K5-HIST1H3A ESTG TFF1 gene PPP5C H2AFX ERBB4jmAcyt1s80 HIST1H2BJ ESR1:estrogen:ERE:NCOA3:EP300HIST3H2BB E1 HIST1H2BA MYC MYCMe3K-10-HIST2H3A ESR1:ER:PGR:P4POLR2C POLR2I AXIN1 geneEBAG9 geneH2BFS HIST1H4 HIST1H2AC HIST1H2AC H2BFS CCND1 gene HIST1H2BO HIST1H2BA H2BFS POLR2C MYCgene:HIST1H2ACnucleosome:ESR1:ESTG:EP300:NCOA3HIST1H2BM H2AFV HIST1H2AD EST17b SMC1A H2AFB1 miR-26B RISC Me2K10-HIST1H3A HIST1H2BK HIST1H2BA HIST1H2BO KDM4B geneH2AFX E1 POLR2L H2AFX GREB1 gene AXIN1 gene CCND1 gene HIST1H2AB HIST1H2BM HSP90AA1 NCOA3 p-S118-ESR1 HIST1H4 HIST1H3A ATPMYC HIST1H2BD HIST2H2AA3 ESR1 CHD1 mRNAHIST1H4 ESR1 HIST2H2BE GREB1 gene HIST1H2BC P4 H2BFS CXCL12 gene HIST1H4 ESR1 ESR1:estrogen:TFF1gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3CCND1HIST1H2BK PPP5C RUNX1 ESR1 HIST3H2BB HIST2H2AC FKBP5 POLR2G KDM4BHIST1H2AJ HIST1H2BL H3F3A CXXC5HIST1H2BA EBAG9 gene:ESR1:ESTGDDX5 H2BFS POLR2E GREB1gene:nucleosome:ESR1:ESTGSTAG2 ESR1 HIST1H2AB HIST1H2BL ESR1 HIST2H2BE HIST1H2BL HIST2H2AC POLR2D MED1PRMT1HIST1H2BK H2AFJ H2AFB1 NCOA3 ESTG FKBP4 HIST1H2AD HIST1H2BO histoneacetyltransferasesCCNT1 BCL2 geneESRs:chaperonecomplexHIST1H2AC ESR1:estrogen:TFF1gene:FOXA1:GATA3ESR1 HIST1H2BB HIST1H2BD PGR gene HIST2H2AA3 NCOA3H2AFB1 TFF3 gene MYBgene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFbESR1 ESTG HIST3H2BB KCTD6 geneHIST1H2BO MYB geneHIST2H2AA3 HIST1H2BK H2AFV ESR1 HSP90AB1 HIST1H2BJ HIST1H2AC H2AFX ESTG MYC ESR1 EST17b H2AFX CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3RUNX1:CBFB:ESR1:estrogen:AXIN1 geneH2AFV HIST2H2AC POLR2H HIST1H2BO HIST3H2BB HIST1H2AB HIST1H2BD NCOA2 RAD21 HIST1H2BO HIST1H3A HIST1H2BN HIST1H2BJ ESR1 HIST1H2BO Me2K5-HIST1H3A H3F3A EP300 HIST1H2BB ESR1 ESR1,2:ESTG homo andheterodimersPOLR2I HIST1H3A TLE3GREB1ESTG SMC3 PGR geneMe2K-10-HIST2H3A FKBP4 HIST3H2BB HIST1H2BD MYBBCL2 gene HIST1H2BM FOS HIST1H2BL HIST1H2AD KDM1AHIST1H2AB HIST1H2AJ POLR2K MYCgene,BCL2gene:H3K9me2,HIST1H2ACnucleosome:ESR1:ESTG:KDM1Ap-S2,S5-POLR2A HIST2H2BE H2AFV Me2K-10-HIST2H3A H2AFZ DDX5H2BFS BLC2gene:HIST1H2ACnuclesome:ESR1:ESTG:EP300HIST1H2BL POLR2H H2AFX ESR1 HSP90:ATP:PTGES3:FKBP52:PGR:P4HIST1H2AC ESTG HIST1H2BC CXCL12 geneATP ESTG HIST1H2BA ESR1dimer:estrogen:TFGAgene:NCOA1ESTG HIST1H2BN FOXA1 H2AFX BCL2 gene HIST1H2BB HIST1H3A HIST1H2BN p-T202,Y204-MAPK3 TFF1,TFF3gene:FOXA1:GATA3HIST3H2BB ATP HIST1H4 HIST1H2BK HIST1H2BM HIST2H2AA3 H2AFV CTSD dimerHIST2H2AA3 ESR1:estrogen:TFGAgene:NCOA1:EP300ESR1 GREB1 gene p-S118-ESR1 dimerERBB4s80H3F3A ESTG HIST1H2BH HIST3H2BB EST17b TFF3gene:FOXA1:GATA3HIST1H2AB HIST1H2BJ NCOAsESTG:ESR1dimer:JUN:FOSPOLR2J H3F3A ESTG HIST1H2BN HIST2H2BE ESTG HIST1H2BK HIST1H2BK Me2K10-HIST1H3A miR-26A RISC ESR1 HIST1H2BL PPID ESTG ESR1 HIST2H2BE Me2K5-HIST2H3A MYC ADPHIST1H2BL HIST1H2BN ESTG HIST1H2BJ ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5HIST2H2AA3 Me2K5-H3F3A HIST1H2BH HIST2H2AC H2AFJ MYCgene,BLC2gene:H3K9me2,HIST1H2ACnucleosome:ESR1:ESTGRUNX1 H2AFX PTGES3 HIST2H2AC GREB1gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2CITED1 HIST1H2BK CCND1gene:nucleosome:ESR1:ESTGTFF3 geneTFF1 gene Me2K5-H3F3A TFF1 geneHIST1H2BL GREB1 mRNA HIST1H2BJ FKBP5 KDM4B-regulatedgenes:H3K9me3nucleosomeERBB4s80:ESR1:estrogen:PGR geneESTG ERBB4jmAcyt1s80 Histone H2AESR1 KDM4Bgene:nucleoplasm:ESR1:ESTGESR1:ESTGHIST2H2AC H2AFB1 ESTG estriol HIST1H2AJ MYC gene GTF2F1 ESTG HIST1H2AC HIST1H2AB p-S63,S73-JUN HIST1H2BH GREB1:ESR1:ESTG:EP300:CREBBPHIST1H2BM HIST1H2BH ESR1 HIST1H2BD CDK9 CCND1 geneH3F3A HIST1H2BL HIST1H2BB estetrol H2AFJ MYB gene HIST1H2BO HIST1H2BN FOXA1 HIST2H2BE HIST1H2BB estriol HSP90AA1 Me2K-10-H3F3A ESR1 HIST1H2BN PiHSP90AA1 CCNT1 NRIP1 GTF2A1(275-376) miR-26B RISC HIST1H2AC CTSD(169-412) TBPHIST1H2BH H2BFS ESR2 miR-26 RISCHIST3H2BB NR5A2HIST1H2BC CHD1 geneHIST1H2BO Me2K-10-H3F3A HIST1H2BH POLR2K PPID FOXA1 ESR1 Signaling by ERBB4HIST2H3A HIST1H2AD PPP5C HIST1H2BH POLR2B p-S63,S73-JUN BCL2 gene HIST1H2AD HIST1H2BA POU2F1 HIST1H2BM HIST1H2BD H2BFS TFF1, TFF3 geneH2AFZ GATA3 GTF2F2 EST17b ESR1 HIST1H2BB ZNF217FKBP4 HIST1H2BK ERBB4s80:ESR1:estrogen:CXCL12 geneEBAG9 gene HIST1H2BC FOSB FKBP4 ESR1 NCOA2 HIST1H2BB DDX5 CHD1 mRNA E1 MYC gene, BCL2 gene:H3K9me2 nucleosomeGATA3 CCND1 gene H3F3A HIST2H2BE ESR1 CDK9 HIST1H2BH HIST1H2BM POLR2D PPID EP300ATP POLR2K ESR1 MYCgene,BCL2gene:HIST1H2ACnuclesome:ESR1:ESTG:EP300KDM4B-regulatedgenes:nucleosome:ESR1:ESTGMe2K-10-H3F3A E1 USF2KCTD6 gene HIST1H2BL CTSD(65-161) Me3K-10-HIST1H3A CTSD gene:ESR1:ESTGH3F3A PPP5C ESR1:estrogen:ERE:NCOA3:TFGA geneESTG:ESR1dimer:ATF2:JUNHIST2H2AC TFIIAEP300 TFF1gene:FOXA1:GATA3HIST1H2BB MYC gene ESR1 HIST1H2BD HIST1H2BJ MYC gene HIST1H2BK Cohesin ComplexHSP90AB1 HIST2H3A HIST1H2BJ Me2K-10-HIST2H3A HIST1H2BO CITED1Me3K-10-HIST2H3A CBFB H2BFS ESTG POLR2G HIST1H2BM HIST1H2BJ ESR1 H2BFS HIST1H2AB H2BFS 963918718722513, 18, 22, 28, 35...2187395829613010966, 16, 17, 42, 43, 59...18739175218