Matrix metalloproteinases (Mus musculus)

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1MetalloelastaseMatrilysinGelatinasesStromelysinsPotential Inducers of TranscriptionCollagenasesInhibitorsGenes Dev 14:2123-2133development and normal physiology.Based on Vu & Werb (2000)OtherMatrix metalloproteinases: effectors ofMembrane-type MMPsEnamelysinMmp21Mmp1aMmp10Mmp14Mmp11BsgMMP26Mmp15Mmp8MMP23AMmp9Mmp7Timp2Mmp16Mmp28Mmp19Mmp17Mmp25Mmp3Mmp24Timp3Mmp2Mmp13Mmp27Tcf20Timp4Mmp23Timp1Mmp20TnfMmp12


Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP129(r20953) with a 93% conversion rate.

Quality Tags

Ontology Terms



  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia


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117913view10:33, 23 May 2021EweitzModified title
69114view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67453view11:03, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
41300view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
35331view08:32, 12 February 2010ThomasModified description
35329view08:31, 12 February 2010Thomasmoved reference from comments to bibliography
34566view21:40, 21 December 2009Khansperslayout and description
34565view21:39, 21 December 2009KhanspersModified description
32432view17:14, 15 August 2009MaintBotFixed text labels
32100view13:45, 14 August 2009MaintBotFixed group labels
31453view21:12, 13 August 2009MaintBotFixed text labels
30892view00:21, 30 July 2009MaintBotConverted from Homo sapiens
21608view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Matrix Metalloproteinases]] moved to [[Pathway:WP441]]: Moved to stable identifier
8256view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Matrix Metalloproteinases]] moved to [[Pathway:Mus musculus:Matrix Metalloproteinases]]: Renaming species
7748view16:15, 18 December 2007MaintBotfixed category names
7429view12:42, 4 November 2007MaintBotAdded categories to GPML
19509view22:19, 22 May 2007M.Braymergpml file for [[Mouse:Matrix_Metalloproteinases]]
6475view22:19, 22 May 2007Kdahlquistgpml file for [[Mouse:Matrix_Metalloproteinases]]

External references


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NameTypeDatabase referenceComment
BsgGeneProduct12215 (Entrez Gene)
Mmp10GeneProduct17384 (Entrez Gene)
Mmp11GeneProduct17385 (Entrez Gene)
Mmp12GeneProduct17381 (Entrez Gene)
Mmp13GeneProduct17386 (Entrez Gene)
Mmp14GeneProduct17387 (Entrez Gene)
Mmp15GeneProduct17388 (Entrez Gene)
Mmp16GeneProduct17389 (Entrez Gene)
Mmp17GeneProduct23948 (Entrez Gene)
Mmp19GeneProduct58223 (Entrez Gene)
Mmp1aGeneProduct83995 (Entrez Gene)
Mmp20GeneProduct30800 (Entrez Gene)
Mmp21GeneProduct214766 (Entrez Gene)
Mmp2GeneProduct17390 (Entrez Gene)
Mmp23GeneProduct26561 (Entrez Gene)
Mmp24GeneProduct17391 (Entrez Gene)
Mmp25GeneProduct240047 (Entrez Gene)
Mmp27GeneProduct234911 (Entrez Gene)
Mmp28GeneProduct118453 (Entrez Gene)
Mmp3GeneProduct17392 (Entrez Gene)
Mmp7GeneProduct17393 (Entrez Gene)
Mmp8GeneProduct17394 (Entrez Gene)
Mmp9GeneProduct17395 (Entrez Gene)
Tcf20GeneProduct21411 (Entrez Gene)
Timp1GeneProduct21857 (Entrez Gene)
Timp2GeneProduct21858 (Entrez Gene)
Timp3GeneProduct21859 (Entrez Gene)
Timp4GeneProduct110595 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)

Annotated Interactions

No annotated interactions
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