Non-homologous end joining (Homo sapiens)

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Ligase VKu70DNA-PKcsKu70DNA-PKcsKu80Ku80MRE11AKu70Ku70Ku80Ku80DNA-PKcsNbs1 ?Ku80XRCC4DNA-PKcsLigase VKu70Ku80NHEJ1DNA-PKcsDNA-PKcsXRCC4Ku70Ku70Ku80Ku80Ku80Ku80XLFRAD50Ku70Ku70DNA-PKcsDNA-PKcsKu70


(From Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

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80022view20:57, 30 April 2015ZariCorrected Ensembl ID for DNA-PKcs
68977view17:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
59183view18:51, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45348view20:25, 7 October 2011KhanspersOntology Term : 'DOID:0014667' removed !
45346view20:25, 7 October 2011KhanspersOntology Term : 'non-homologous end joining pathway of double-strand break repair' added !
41150view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
39394view19:04, 20 November 2010Chetan1Ontology Term : 'disease of metabolism' added !
35395view09:48, 12 February 2010MartijnVanIerselModified description
32098view13:44, 14 August 2009MaintBotFixed group labels
29612view12:10, 23 May 2009MartijnVanIerselUpdated ensembl references
22671view14:58, 14 November 2008Thomascapitalized title
21602view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:non-homologous end joining]] moved to [[Pathway:WP438]]: Moved to stable identifier
15846view19:46, 5 June 2008KhanspersAdded gene IDs
14981view19:57, 24 May 2008AlexanderPicoGrouped and connected
9596view11:40, 9 January 2008Thomasadded to cellular process category
9588view10:18, 9 January 2008Thomasadded gene identifiers
9583view09:46, 9 January 2008Thomasmade a start with NHEJ pathway

External references


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NameTypeDatabase referenceComment
DNA-PKcsGeneProductENSG00000253729 (Ensembl)
Ku70GeneProductENSG00000196419 (Ensembl)
Ku80GeneProductENSG00000079246 (Ensembl)
Ligase VGeneProduct
MRE11AGeneProductENSG00000020922 (Ensembl)
NHEJ1GeneProductENSG00000187736 (Ensembl)
Nbs1 ?GeneProduct
RAD50GeneProductENSG00000113522 (Ensembl)
XLFGeneProduct79840 (Entrez Gene)
XRCC4GeneProductENSG00000152422 (Ensembl)

Annotated Interactions

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