EGF/EGFR Signaling Pathway (Homo sapiens)

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SHC1IP3PIP2PIP2Internalization, degradation and recycling of EGFRDAGPIP3CYNURegulation of actin polymerizationERK1/2, ERK5, p38MAPK, JNK and NFKB mediated gene expressionCa2+ReleaseCYNFKB pathwayNUCYNUNUEGF/EGFR Signaling PathwayCYNUFOSJUNPDPK1ERBB2PRKCIRAF1ABI1LIMK2RPS6KA1RAB5ACDC42CAV2SHC1SH3GL2STAT5AARHGEF1ARF6DNM1PRKCBFOXO4PCNAEPS8GRB10RASA1RALAKRASINPPL1ABL1RALBP1ERRFI1DOK2NEDD4PTPRRTNK2PRKCDPTK2BNEDD8GJA1VAV3MAP2K2STAT1PIAS3MTORVAV2PLSCR1SH3KBP1PLD1IQGAP1EGFREGFRRICTORCSKAP2S1ITCHAURKASTAT5BEGFRSOS2FOSBCOX2SH2D2AHRASIQSEC1MAP3K4BCAR1STAMBPJAK1MAP2K5PTK6SOS1EPS15L1PTPN12INPP5DSTAMVAV1NCOA3SRCEPS15MEF2DEPN1MAPK7PRKCAELK1HGSSTMN1ATF1SYNJ1CRKLATXN2MAPK14RPS6KB1RPS6KA5MYBL2GRIM19STAM2SP1NCK2MAPK3USP6NLREPS2RALBMAPK1NOS3MAPK9BRAFASAP1FOXO1AP2B1JAK2CAV1PTPN5RAC1USP8MAPK8MAP3K1TWIST1PEBP1RAP1AGRB2ELK4CREB1MAP3K3GAB2STXBP1GAB1PLCE1CAMK2APLCG1ROCK1PIK3R1EGFPIK3C2BSPRY2MAP3K2RIN1RPS6KA3PTENPLD2AKT1RPS6KA2SH3GL3MAP2K1NCK1STAT3CRKMAP4K1PRKCZAP2A1PIK3R2PLSCR1JUNDE2F1EIF4EBP1RALGDSPTPN11PGTPPGTPPPPGTPPUbPPPPPPPPPGTPPUbPPPPPPPPPPPPPGTPPPPPPPPPpPPPGTPGTPPGTPPPPPPPPPEGFREGFRCBLBCBLCBLCSRCPGRB2PSOS1RALBP1CBLBCBLPCBLCPLD1PAK1PSTAT3STAT1PSTAT5BPPSTAT5APCFL1PTK2PEGFAP2M1PIAS3MEF2ASRCPXNEndosome/Multivesicular bodies/LysozomeHRASGTPVAV2PSP1PEPS8MEF2CRPS6KA3MAPK3MAPK1MAPK9PMAPK8PMAPK7MAP2K2MAP2K1NUCYCYNUNUNUCYNUCYCYProtein - protein dissociationReceptorProteinEnzyme ComplexmRNAProteinProteinLigandSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMolecule