EGF/EGFR Signaling Pathway (Homo sapiens)

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SHC1DAGIP3Internalization, degradation and recycling of EGFRPIP2PIP3PIP2NUCYCYCa2+EGF/EGFR Signaling PathwayNURegulation of actin polymerizationERK1/2, ERK5, p38MAPK, JNK and NFKB mediated gene expressionCYReleaseNUNFKB pathwayNUCYNURPS6KA1PTPRRCDC42PCNAPRKCIVAV2MAP3K4MAP3K2NEDD4JAK1LIMK2RASA1REPS2SHC1SH3GL2INPPL1NEDD8PDPK1GJA1MYBL2FOSSTAT3STMN1PRKCBIQGAP1RPS6KA3HRASSTAM2JUNDCSKMAP2K5ERBB2CRKLRPS6KA5MAPK8GRIM19SP1PTPN12RAB5APLSCR1RAF1CREB1PLSCR1EPN1PIK3R2TWIST1DOK2ROCK1ITCHEGFARHGEF1RALABCAR1PTK2BNCK1PEBP1NOS3IQSEC1PTENUSP8MAP2K2PIK3C2BRIN1RALBP1PRKCAMTORCRKSH3GL3TNK2EGFRPTPN5SOS1PIK3R1NCOA3ELK1KRASRICTORJAK2PRKCZSTAT1EPS8MAP2K1RALGDSFOSBVAV3SOS2RPS6KB1AKT1USP6NLCAV2PLD2GRB10RAP1AARF6MAPK1PLD1CAMK2ASPRY2PTPN11BRAFMAP3K1DNM1MAPK14PTK6NCK2VAV1STAMSH3KBP1EPS15AP2S1RPS6KA2AP2B1PLCE1E2F1GRB2RALBSH2D2ASTAT5AAP2A1EGFRSRCMAPK3RAC1ATF1CAV1MAPK9MEF2DGAB1ERRFI1FOXO4STAMBPEGFRCOX2PLCG1MAP4K1EPS15L1MAP3K3INPP5DAURKASYNJ1ABL1STXBP1ELK4GAB2HGSMAPK7JUNSTAT5BPIAS3EIF4EBP1ABI1PRKCDATXN2FOXO1ASAP1PPPPUbPPPPGTPPPPPGTPPPPPUbpPPPPPPPPPPPPPPPPPPPGTPPGTPPPPPPPGTPGTPPPPGTPPPGTPPPEGFREGFRCBLBCBLCBLCSRCPGRB2PSOS1RALBP1CBLBCBLPCBLCPLD1PAK1PSTAT3PSTAT1STAT5BPSTAT5APPCFL1PTK2PEGFAP2M1PIAS3MEF2ASRCPXNEndosome/Multivesicular bodies/LysozomeHRASGTPVAV2PSP1PEPS8MEF2CRPS6KA3MAPK3MAPK1MAPK9MAPK8PPMAPK7MAP2K2MAP2K1NUCYCYNUNUNUCYNUCYCYProtein - protein dissociationReceptorProteinEnzyme ComplexmRNAProteinProteinLigandSmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageMolecule