Eicosanoid metabolism via cytochrome P450 monooxygenases (CYP) (Mus musculus)

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21PPAR gammaEphx2Arachidonic acid116-HETE17-HETE118-HETE1119-HETE20-HETE15,6-EpETrE18,9-EpETrE1111,12-EpETrE14,15-EpETrE115,6-DiHETrE8,9-DiHETrE11,12-DiHETrE14,15-DiHETrECyp2c29Cyp2c37Cyp2c38Cyp2c39Cyp2c40Cyp2c44Cyp2c54Cyp2c55Cyp2j5Cyp4a10Cyp4a12aCyp4a12bCyp4f14Cyp4f18111PPAR alpha1


This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [1] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [2]).

Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[3], lipooxygenases(LOX)[4], or cytochrome P450 monooxygenases (CYP)[5]. This pathway visualises the third route, via CYP.

Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

Quality Tags

Ontology Terms



  1. Dennis EA, Norris PC; ''Eicosanoid storm in infection and inflammation.''; Nat Rev Immunol, 2015 PubMed Europe PMC Scholia
  2. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia


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117876view10:19, 23 May 2021EweitzModified title
106330view08:42, 21 August 2019DeSlAdded general LipidMaps publication.
106270view14:30, 19 August 2019DeSlModified description
102925view12:53, 29 January 2019DeSlAdded another lit.ref
102914view12:01, 28 January 2019DeSlOntology Term : 'eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma' added !
102913view12:01, 28 January 2019DeSlModified description
102911view11:59, 28 January 2019DeSlAdded details from lit. ref
102910view11:52, 28 January 2019DeSlChanged layout
102908view10:59, 28 January 2019DeSlModified description
102895view16:21, 26 January 2019EgonwModified description
102888view15:47, 25 January 2019DeSlModified title
102884view15:46, 25 January 2019DeSlOntology Term : 'PW:0000002' removed !
102883view15:46, 25 January 2019DeSlOntology Term : 'cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism' added !
102882view15:45, 25 January 2019DeSlOntology Term : 'eicosanoid metabolic pathway' added !
102879view15:44, 25 January 2019DeSlModified description
102877view15:44, 25 January 2019DeSlModified description
98612view12:55, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98579view15:55, 17 September 2018EoinfahyNew pathway

External references


View all...
NameTypeDatabase referenceComment
11,12-DiHETrEMetaboliteLMFA03050008 (LIPID MAPS)
11,12-EpETrEMetaboliteLMFA03090010 (LIPID MAPS)
14,15-DiHETrEMetaboliteLMFA03050010 (LIPID MAPS)
14,15-EpETrEMetaboliteLMFA03080005 (LIPID MAPS)
16-HETEMetaboliteLMFA03090010 (LIPID MAPS)
17-HETEMetaboliteLMFA03060091 (LIPID MAPS)
18-HETEMetaboliteLMFA03060092 (LIPID MAPS)
19-HETEMetaboliteLMFA03060106 (LIPID MAPS)
20-HETEMetaboliteLMFA03060009 (LIPID MAPS)
5,6-DiHETrEMetaboliteLMFA03050004 (LIPID MAPS)
5,6-EpETrEMetaboliteLMFA03080002 (LIPID MAPS)
8,9-DiHETrEMetaboliteLMFA03050006 (LIPID MAPS)
8,9-EpETrEMetaboliteLMFA03080003 (LIPID MAPS)
Arachidonic acidMetaboliteLMFA01030001 (LIPID MAPS)
Cyp2c29Protein13095 (Entrez Gene)
Cyp2c37Protein13096 (Entrez Gene)
Cyp2c38Protein13097 (Entrez Gene)
Cyp2c39Protein13098 (Entrez Gene)
Cyp2c40Protein13099 (Entrez Gene)
Cyp2c44Protein226143 (Entrez Gene)
Cyp2c54Protein404195 (Entrez Gene)
Cyp2c55Protein72082 (Entrez Gene)
Cyp2j5Protein13109 (Entrez Gene)
Cyp4a10GeneProduct13117 (Entrez Gene)
Cyp4a12aGeneProduct277753 (Entrez Gene)
Cyp4a12bGeneProduct13118 (Entrez Gene)
Cyp4f14GeneProduct64385 (Entrez Gene)
Cyp4f18GeneProduct72054 (Entrez Gene)
Ephx2GeneProduct13850 (Entrez Gene)
PPAR alphaProteinP23204 (Uniprot-TrEMBL) AKA Peroxisome proliferator-activated receptor alpha
PPAR gammaProteinP37238 (Uniprot-TrEMBL) AKA Peroxisome proliferator-activated receptor gamma

Annotated Interactions

No annotated interactions

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