Glycerolipids and Glycerophospholipids (Mus musculus)

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1, 222232:0 chainAcyl-CoA lengthof side chains:CoA(16:0)CoALCL2222222222222Gpam2PPap2aCrls1Chpt1PA2Glycerol-3-PPcyt22Cds11-acyl-LPAPisd2Dgat1Ptdss2CholineCDP-EtnPnpla2Pld1DgkzPnpla3PE2Ptdss1PemtAgpat42Acyl-CoADAG2CDP-DAGPGP2PG2CLPI22PC2Choline-PCDP-CholinePS21-acyl-LPCPE-MePE-Me2CdiptChkbPcyt1aEtn-PEtnEtnk1Agpat62TAGDgat222-acyl-PA1-acyl-PEPla2g1bCoA(16:1)CoA(18:0)CoA(18:1)CoA(20:1)CoA(20:0)CoA(20:4)CoA(16:0)32:1 chainCoA(16:0)34:0 chainCoA(16:0)34:1 chainCoA(16:0)CoA(18:0)36:0 chainCoA(18:0)36:1 chainCoA(18:0)CoA(18:1)CoA(18:0)38:0 chain36:1 chainCoA(18:0)CoA(18:0)38:4 chain2Common pathwayfor TAG andphospholipidsDe novosynthesis ofphospholipidsFatty acidremodelingLPGLPILPCPla2g1bLPSLPE


Description

This pathway is inspired by the Lipidmaps>Glycerolipids and Glycerophospholipids Pathways expended pathway display [1].

Glycerolipids are composed of mono-, di-, and tri-substituted glycerols, which all function as energy storage.

Glycerophospholipids are also based on glycerol phospholipids, and serve as the main component of biological membranes.

Quality Tags

Ontology Terms

 

Bibliography

  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  2. Yamashita A, Hayashi Y, Matsumoto N, Nemoto-Sasaki Y, Oka S, Tanikawa T, Sugiura T; ''Glycerophosphate/Acylglycerophosphate acyltransferases.''; Biology (Basel), 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106451view11:42, 29 August 2019DeSlUpdated LipidMaps ID for TAG
106331view08:49, 21 August 2019DeSlAdded general LipidMaps publication.
106222view15:08, 16 August 2019DeSlAnnotaed FA remodeling IDs if available.
106221view14:52, 16 August 2019DeSlAnnotated saturated Acyl-CoA side chain DataNodes.
105758view17:44, 15 August 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
105753view15:05, 15 August 2019DeSlOntology Term : 'glycerophospholipid metabolic pathway' added !
105752view15:05, 15 August 2019DeSlOntology Term : 'PW:0000002' removed !
105751view15:05, 15 August 2019DeSlOntology Term : 'glycerolipid metabolic pathway' added !
105750view15:03, 15 August 2019DeSlAdded FA remodelling steps and colours to describe PW.
105747view14:47, 15 August 2019DeSlAdded CoA as side metabolite with additonal lit. ref. info
105746view14:39, 15 August 2019DeSlAdded lit. ref to specific reactions
105745view14:22, 15 August 2019DeSlModified title
105744view14:20, 15 August 2019DeSlAdded CoA side chains
105743view14:05, 15 August 2019DeSlAdded missing dataNodes, updated middle and righthand side of PW
105742view13:50, 15 August 2019DeSlStarted updating layout on lefthand side.
105741view13:35, 15 August 2019DeSlModified description
105740view13:30, 15 August 2019DeSlModified description
105332view12:04, 31 July 2019EgonwThe class, not the reference lipid.
98618view17:23, 21 September 2018EoinfahyAdded LIPID MAPS tag to CDP-DAG
98611view12:43, 21 September 2018RyanmillerOntology Term : 'classic metabolic pathway' added !
98575view15:51, 17 September 2018EoinfahyNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-acyl-LPAMetaboliteLMGP10050000 (LIPID MAPS) aka 1-acyl-sn-glycero-3-phosphate , 1-acylglycerophosphate, lysophosphatic acid
1-acyl-LPCMetaboliteLMGP01050000 (LIPID MAPS)
1-acyl-PEMetaboliteLMGP02050000 (LIPID MAPS)
2-acyl-PAMetaboliteLMGP1005AA00 (LIPID MAPS)
Acyl-CoAMetaboliteLMFA07050000 (LIPID MAPS)
Agpat4GeneProduct68262 (Entrez Gene)
Agpat6GeneProduct102247 (Entrez Gene)
CDP-CholineMetabolite13804 (PubChem-compound)
CDP-DAGMetaboliteLMGP13010000 (LIPID MAPS)
CDP-EtnMetabolite123727 (PubChem-compound)
CLMetaboliteLMGP12010000 (LIPID MAPS)
CdiptGeneProduct52858 (Entrez Gene)
Cds1GeneProduct74596 (Entrez Gene)
ChkbGeneProduct12651 (Entrez Gene)
Choline-PMetabolite135437 (PubChem-compound)
CholineMetabolite305 (PubChem-compound)
Chpt1GeneProduct212862 (Entrez Gene)
CoA(16:0)Metabolite1763-10-6 (CAS) AKA "Coenzyme A, S-​hexadecanoate"
CoA(16:1)MetabolitePosition of double bond is unclear.
CoA(18:0)Metabolite362-66-3 (CAS) AKA "Coenzyme A, S-​octadecanoate"
CoA(18:1)Metabolite
CoA(20:0)Metabolite15895-27-9 (CAS) AKA "Coenzyme A, S-​eicosanoate"
CoA(20:1)Metabolite
CoA(20:4)Metabolite
CoAMetaboliteCHEBI:15346 (ChEBI)
Crls1GeneProduct66586 (Entrez Gene)
DAGMetaboliteLMGL02010000 (LIPID MAPS)
Dgat1GeneProduct13350 (Entrez Gene)
Dgat2GeneProduct67800 (Entrez Gene)
DgkzGeneProduct104418 (Entrez Gene)
Etn-PMetabolite1015 (PubChem-compound)
EtnMetabolite700 (PubChem-compound)
Etnk1GeneProduct75320 (Entrez Gene)
Glycerol-3-PMetabolite439162 (PubChem-compound)
GpamGeneProduct14732 (Entrez Gene)
LCLMetaboliteAKA "Lyso-cardiolipin",(not part of LipidMaps ontology)
LPCMetaboliteLMGP01050000 (LIPID MAPS) AKA "1-acyl-sn-glycero-3-phosphocholine"
LPEMetaboliteLMGP02050000 (LIPID MAPS) AKA "1-acyl-sn-glycero-3-phosphoethanolamine"
LPGMetaboliteAKA "Lysyl-phosphatidylglycerol" (not part of LipidMaps ontology)
LPIMetaboliteAKA "Lysophosphatidylinositol" (not part of LipidMaps ontology)
LPSMetaboliteAKA "1-acyl-sn-glycero-3-phospho-serine",(not part of LipidMaps ontology)
PAMetaboliteLMGP10010000 (LIPID MAPS) aka phosphatidic acid
PCMetaboliteLMGP01010000 (LIPID MAPS)
PE-Me2MetaboliteLMGP0201AB00 (LIPID MAPS)
PE-MeMetaboliteLMGP0201AA00 (LIPID MAPS)
PEMetaboliteLMGP02010000 (LIPID MAPS)
PGMetaboliteLMGP04010000 (LIPID MAPS)
PGPMetaboliteLMGP05010000 (LIPID MAPS)
PIMetaboliteLMGP06010000 (LIPID MAPS)
PPap2aGeneProduct19012 (Entrez Gene)
PSMetaboliteLMGP03010000 (LIPID MAPS)
Pcyt1aGeneProduct13026 (Entrez Gene)
Pcyt2GeneProduct68671 (Entrez Gene)
PemtGeneProduct18618 (Entrez Gene)
PisdGeneProduct320951 (Entrez Gene)
Pla2g1bGeneProduct18778 (Entrez Gene)
Pld1GeneProduct18805 (Entrez Gene)
Pnpla2GeneProduct66853 (Entrez Gene)
Pnpla3Protein116939 (Entrez Gene)
Ptdss1GeneProduct19210 (Entrez Gene)
Ptdss2GeneProduct27388 (Entrez Gene)
TAGMetaboliteLMGL03010000 (LIPID MAPS)

Annotated Interactions

No annotated interactions

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