TCA Cycle (Mus musculus)

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MitochondrionCytosolFatty Acid SynthesisPpm2cOxaloacetateMdh1Pdha2SdhcMalatePdk4SuccinateIdh2Pdk2Suclg2Idh3gOgdhGlycolysisElectron Transport ChainDlstSuccinyl-CoAPdha1OxaloacetateCitrateSuclg1DldFumaratePdk1Idh3aDldSdhbIsocitrate4833426J09RikPdhxGluconeogenesisMdh2Pdk3Idh3bDegradation of Fatty Acids Containing an Even Number of CarbonsAco2SdhaPyruvateFh1MalatePcxSucla2alpha-KetoglutarateDlatCsSdhdPdhbAcetyl-CoADegradation of Fatty Acids Containing an Even Number of Carbons


The citric acid cycle, also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-catalysed chemical reactions of central importance in all living cells that use oxygen as part of cellular respiration. In eukaryotes, the citric acid cycle occurs in the matrix of the mitochondrion. The components and reactions of the citric acid cycle were established by seminal work from both Albert Szent-Gyorgyi and Hans Krebs. [From Wikipedia]


This pathway was inferred from Homo sapiens pathway WP78(r28870) with a 100% conversion rate.

Quality Tags

Ontology Terms



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114004view21:59, 16 December 2020EgonwSix more pathways clickable
106894view13:36, 17 September 2019MaintBotHMDB identifier normalization
70013view23:47, 11 July 2013MaintBotupdated to 2013 schema
67686view11:49, 26 June 2013DdiglesOntology Term : 'citrate cycle pathway' added !
57464view17:45, 28 January 2013Mkutmonfixed unconnected lines
44777view10:56, 2 October 2011MartijnVanIerselabbriviated alpha
43569view13:40, 1 July 2011AdrienDefayPeriodical save, work in progress
41342view00:26, 2 March 2011MaintBotRemoved redundant pathway information and comments
32430view17:13, 15 August 2009MaintBotFixed text labels
32096view13:44, 14 August 2009MaintBotFixed group labels
31450view21:11, 13 August 2009MaintBotFixed text labels
30839view00:04, 30 July 2009MaintBotConverted from Homo sapiens
21594view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Krebs-TCA Cycle]] moved to [[Pathway:WP434]]: Moved to stable identifier
8238view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Krebs-TCA Cycle]] moved to [[Pathway:Mus musculus:Krebs-TCA Cycle]]: Renaming species
7739view16:14, 18 December 2007MaintBotfixed category names
7376view12:42, 4 November 2007MaintBotAdded categories to GPML
19502view22:19, 22 May 2007M.Braymergpml file for [[Mouse:Krebs-TCA_Cycle]]
6472view22:19, 22 May 2007Kdahlquistgpml file for [[Mouse:Krebs-TCA_Cycle]]

External references


View all...
NameTypeDatabase referenceComment
4833426J09RikGeneProduct382051 (Entrez Gene)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
Aco2GeneProduct11429 (Entrez Gene)
CitrateMetaboliteHMDB0000094 (HMDB)
CsGeneProduct12974 (Entrez Gene)
Degradation of Fatty Acids Containing an Even Number of CarbonsPathwayWP1269 (WikiPathways)
DlatGeneProduct235339 (Entrez Gene)
DldGeneProduct13382 (Entrez Gene)
DlstGeneProduct78920 (Entrez Gene)
Electron Transport ChainPathwayWP295 (WikiPathways)
Fatty Acid SynthesisPathwayWP336 (WikiPathways)
Fh1GeneProduct14194 (Entrez Gene)
FumarateMetaboliteHMDB0000134 (HMDB)
GluconeogenesisPathwayWP157 (WikiPathways)
GlycolysisPathwayWP157 (WikiPathways)
Idh2GeneProduct269951 (Entrez Gene)
Idh3aGeneProduct67834 (Entrez Gene)
Idh3bGeneProduct170718 (Entrez Gene)
Idh3gGeneProduct15929 (Entrez Gene)
IsocitrateMetaboliteHMDB0000193 (HMDB)
MalateMetaboliteHMDB0000156 (HMDB)
Mdh1GeneProduct17449 (Entrez Gene)
Mdh2GeneProduct17448 (Entrez Gene)
OgdhGeneProduct18293 (Entrez Gene)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
PcxGeneProduct18563 (Entrez Gene)
Pdha1GeneProduct18597 (Entrez Gene)
Pdha2GeneProduct18598 (Entrez Gene)
PdhbGeneProduct68263 (Entrez Gene)
PdhxGeneProduct27402 (Entrez Gene)
Pdk1GeneProduct228026 (Entrez Gene)
Pdk2GeneProduct18604 (Entrez Gene)
Pdk3GeneProduct236900 (Entrez Gene)
Pdk4GeneProduct27273 (Entrez Gene)
Ppm2cGeneProduct381511 (Entrez Gene)
PyruvateMetaboliteHMDB0000243 (HMDB)
SdhaGeneProduct66945 (Entrez Gene)
SdhbGeneProduct67680 (Entrez Gene)
SdhcGeneProduct66052 (Entrez Gene)
SdhdGeneProduct66925 (Entrez Gene)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)
Sucla2GeneProduct20916 (Entrez Gene)
Suclg1GeneProduct56451 (Entrez Gene)
Suclg2GeneProduct20917 (Entrez Gene)

Annotated Interactions

No annotated interactions
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