Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)

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474, 717775327787Other effectorsClaudinsCollagensNucelusEpithelial-Mesenchymal TransitionHypoxiaUbiquitin-mediateddegradationDegradationTGFb and Ras/MAPKNOTCH1pre-miR-9-2TUSC3CDH1AKT1MAPK3TRAF6COL4A1MAP2K1FZD10RAF1PIK3CARBPJJUPCTNNB1JAG1GSK3BCLDN1HRASSMAD4TGFB1TWIST1FOXQ1Tyrosine kinase receptorsTP53CollagenNUBPLMMPsClaudinsMEF2DFMNL2GDF15PROX1CytokeratinsSTRAPTGFBR1WNT16TMPRSS4EIF5A2NRP2PPNR2C2MAP2K3MAP2K6MAP2K4MAPK14MAPK8SHC1GRB2SOS1SOS2KRASMAP2K2MAPK1AKT2AKT3SNAI1SNAI2NOTCH2NOTCH3NOTCH47HIF1A7JAG2DLL1DLL3DLL4DLK1CDKL2TWIST2PCDH2ZEB2FOXC2FOXM1FN1SNAI1SNAI1PPPSNAI1PCTDSP1SNAI1PPPKD1PAK1LATS2TWIST1TWIST2PPTWIST1TWIST2ZEB2SumoZEB2SumoSUZ12RBBP4EEDEZH2ZEB176TGFBR26TGFB2TGFB3MAPK11MAPK13MAPK12SNAI1PSMAD2SMAD3DSPPKP1PKP2CRB3MPP5VTNMMP157MMP2MMP9ID1ID27CDH17ClaudinsOCLNDSPCDH2FN1VTNSPARCITGA5CDH1PKP1PKP2CRB3TJP1CDH2VTNOCLNCLDN2CLDN3CLDN4CLDN5CLDN6CLDN7CLDN8CLDN9CLDN10CLDN11CLDN12CLDN14CLDN15CLDN16CLDN17CLDN18CLDN19CLDN20CLDN22CLDN23CLDN24COL4A2COL4A3COL4A4COL4A5COL4A6WNT1WNT4WNT2WNT3WNT5AWNT6WNT7AWNT7BWNT8AWNT8BWNT10BWNT11WNT2BWNT9AWNT9BWNT10AWNT5BWNT3AWNT3AFZD2FZD5FZD3FZD1FZD4FZD6FZD7FZD8FZD9LRP5LRP6PIK3CBPIK3CDPIK3R1PIK3R2PIK3R3


Description

Epithelial to mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, and gain mesenchymal properties, such as increased motility. In colorectal cancer (CRC), EMT is associated with an invasive or metastatic phenotype. During EMT, tumor cells undergo tight junction dissolution, disruption of apical–basal polarity, and reorganization of the cytoskeletal architecture, which enable cells to develop an invasive phenotype. In cancer cells, EMT is abnormally regulated by extracellular stimuli derived from the tumor microenvironment, including growth factors and inflammatory cytokines, along with intra-tumoral physical stresses such as hypoxia. Therefore, EMT programming allows tumor cells to adapt to the constant changes of the human tumor microenvironment, and thus to successfully metastasize. This pathway summarizes the major signaling pathways and inducers that promote EMT in CRC.

A set of core transcription factors regulate EMT: SNAIL family of zinc-finger transcription factors SNAIL/SLUG; the zinc finger E-box binding homeobox (ZEB) family of transcription factors ZEB1/ZEB2, and the TWIST family of basic helix-loop-helix (bHLH) transcription factors TWIST1/TWIST2. (Adapted from Vu et al.)

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Bibliography

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  1. Kranenburg O; ''Prometastatic NOTCH Signaling in Colon Cancer.''; Cancer Discov, 2015 PubMed
  2. Lu MH, Huang CC, Pan MR, Chen HH, Hung WC; ''Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9.''; Clin Cancer Res, 2012 PubMed
  3. Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F, Wu G; ''Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis.''; Cancer Res, 2011 PubMed
  4. Yang C, Chen H, Tan G, Gao W, Cheng L, Jiang X, Yu L, Tan Y; ''FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer.''; Cancer Lett, 2013 PubMed
  5. Vu T, Datta PK; ''Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis.''; Cancers (Basel), 2017 PubMed
  6. Lamouille S, Xu J, Derynck R; ''Molecular mechanisms of epithelial-mesenchymal transition.''; Nat Rev Mol Cell Biol, 2014 PubMed
  7. Abba M, Patil N, Rasheed K, Nelson LD, Mudduluru G, Leupold JH, Allgayer H; ''Unraveling the role of FOXQ1 in colorectal cancer metastasis.''; Mol Cancer Res, 2013 PubMed
  8. Li Q, Wu J, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S; ''Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition.''; Am J Cancer Res, 2015 PubMed

History

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CompareRevisionActionTimeUserComment
97604view12:00, 29 May 2018AMTanOntology Term : 'colon epithelial cell' added !
97583view22:40, 26 May 2018AlexanderPicoModified title
97138view22:02, 30 April 2018Khanspersadded cell label
97137view21:54, 30 April 2018KhanspersModified title
97006view23:30, 25 April 2018KhanspersModified title
96593view23:50, 22 March 2018KhanspersModified description
96592view23:17, 22 March 2018KhanspersOntology Term : 'disease of cellular proliferation' added !
96591view20:56, 22 March 2018KhanspersModified description
96590view20:45, 22 March 2018Khansperswork in progress
96586view16:45, 22 March 2018KhanspersOntology Term : 'colorectal cancer' added !
96585view04:27, 22 March 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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pre-miR-9-2GeneProductENSG00000284447 (Ensembl)

Annotated Interactions

No annotated interactions

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