Ebola Virus Pathway on Host (Homo sapiens)

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23341323243621511439ITGA2Filamin ACLEC10AASGR1ADAM17ICAM2ICAM3RHOBCD209CLEC4MHAVCR1MHC1GAS6TYRO3ITGA3ITGA4ITGA5ITGA1ITGA6ITGB1ITGB3BST2RAB7ACell MembraneRAB5ANPC1NPC2CTSBCTSLLysosomeNucleusAXLMERTKIKBKEIRF7KPNA1CLEC4GVP35VP24IQGAP1VP40TBK1EBOLAC1QBPTLR4TIMD4VIRUS'RNATPCN2TSG101STAT1NEDD4SOCS3PIK3RCDC42Trans-InfectionMHC2Macropinocytosis12IRF318Interferon ResponseExit of Secreted GPAssembly and BuddingCLATHRINITGAVsGPCytokine Signal420121910CLEC6AMBL2GP1,2333316222032CAVEOLINFOLR1RHOC2233372525ssGP7Transcription, Translation and ReplicationVP30Cell AdhesionImmune Surveillance LNPLopes, E. N. 2017Endosome33Fusion toCleave EnvelopeFusion to Ebola's GPChanges the pH34243434GP30RAC1172626EGFRExit byAKT1MFGE8272727CD300APRKRA27DDX5866HAVCR2IL4DAB2IPTFAP2ARAB9AEIF2AK215EIF2S11VPS33A1VPS18VPS39VPS41VPS11VPS16NFKBVPS4A25dsRNAEPS1522ERK2RASA2RHOAGELSOLIN21ACTINActin CytoskeletonEP300CREBBP444CDC44F-ACTINFILAMINPAK13838TIAM132VAV2IGF1R2129CLTCCLTACLTBCLTCL1CAV1CAV2CAV3PIK3R1PIK3CAPIK3CBPIK3CDPIK3R3PIK3R2IsoformsPP1LC8TOP15FLNAFLNBFLNCGSNSCINMAPK1MAPK3NFKB1NFKB2RELRELAACTN1ACTN4ACTBACTG1HLA-AHLA-BHLA-CHLA-DMAHLA-DMBHLA-DOAHLA-DOBHLA-DPA1HLA-EHLA-FHLA-GHLA-DPB1HLA-DQA1HLA-DQA2HLA-DQB1HLA-DQB2HLA-DRAHLA-DRB1HLA-DRB3HLA-DRB4HLA-DRB5RELBEBOLAEBOLAPtdSerGP3831Filamin B9Filamin C35282414


Description

The Ebola virus (EBOV) pathway represents the virus infection on humans, depicted from the left to the right of the picture. The initial targets are macrophages and dendritic cells, but the virus has tropism to infect all kinds of cells, with the exception of lymphocytes. Here we represent all cells in general whithin one diagram.

Ebola attaches to the plasma membrane and after that a viral glycoprotein induces penetration by endocytosis. This process is made by membrane proteins. During the penetration, its particles travel in compartments where viral glycoproteins are cleaved and fused to the endosomal membrane, which results in the uncoation of viral particles into the cell's cytoplasm. The virus then begins replicating and down-regulating the host's immune response. During the release process, the newly-created viruses are released from host cells, either by causing them to break apart, by waiting for their death or by budding off through their membrane. Depending on the type of infected cell some trans-infection could happen.

This pathway was built using a text-mining approach to obtain interactions between genes related to this process. To our knowledge, it is the first comprehensive pathway depicting the Ebola pathway to date.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
101851view14:32, 13 November 2018Elisson nl
101850view14:30, 13 November 2018Elisson nlInteractions correction
98605view20:09, 20 September 2018Elisson nlModified description
98604view19:52, 20 September 2018Elisson nlModified description
98603view19:48, 20 September 2018Elisson nlModification in interactions
98602view19:09, 20 September 2018Elisson nlAnnotated interaction
98332view04:31, 23 August 2018Elisson nlModified description
98331view04:08, 23 August 2018Elisson nlReferences Accentuation Correction
98330view03:54, 23 August 2018Elisson nlReferences Changed
98292view15:35, 16 August 2018DeSlAdded last missing IDs, coloured MHC1 and 2 subunits for clarity 9couldn't find a ID for these groups). Also added a lit. reference describing the effect of LC8 on VP35
98291view15:17, 16 August 2018DeSlAdded more identifiers.
98290view14:57, 16 August 2018DeSlModified description
97372view19:31, 11 May 2018Elisson nlNew References
97362view20:19, 10 May 2018Elisson nlReferences
97361view19:57, 10 May 2018Elisson nlReferences
97360view19:37, 10 May 2018Elisson nlReferences
97357view19:15, 10 May 2018Elisson nlReferences
97356view19:12, 10 May 2018Elisson nlReferences
97353view19:00, 10 May 2018Elisson nlReferences
97351view18:55, 10 May 2018Elisson nlNew References
97327view19:23, 9 May 2018KhanspersOntology Term : 'viral infectious disease' added !
97326view19:22, 9 May 2018KhanspersOntology Term : 'Ebola hemorrhagic fever' added !
97325view19:22, 9 May 2018Khanspersadded xrefs
97170view21:45, 2 May 2018Elisson nlReferences
96845view17:45, 12 April 2018Elisson nlModified description
96805view10:25, 9 April 2018DeSlChanged lines to graphical lines for Ebola virus drawing
96804view10:17, 9 April 2018DeSlAdded IDs from https://www.wikipathways.org/index.php/Pathway:WP4180
96119view02:55, 20 February 2018Elisson nlModified description
96118view02:47, 20 February 2018Elisson nlNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTBGeneProductENSG00000075624 (Ensembl)
ACTG1GeneProductENSG00000184009 (Ensembl)
ACTINGeneProductIPR004000 (InterPro)
ACTN1GeneProductENSG00000072110 (Ensembl)
ACTN4GeneProductENSG00000130402 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
AKT1GeneProductENSG00000142208 (Ensembl)
ASGR1GeneProductENSG00000141505 (Ensembl)
AXLGeneProductENSG00000167601 (Ensembl)
BST2GeneProductENSG00000130303 (Ensembl)
C1QBPGeneProductENSG00000108561 (Ensembl)
CAV1GeneProductENSG00000105974 (Ensembl)
CAV2GeneProductENSG00000105971 (Ensembl)
CAV3GeneProductENSG00000182533 (Ensembl)
CAVEOLINGeneProductIPR001612 (InterPro)
CD209GeneProductENSG00000090659 (Ensembl)
CD300AGeneProductENSG00000167851 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl)
CDC44GeneProductP35251 (Uniprot-TrEMBL) Annotated according to synonimic name with RFC1 according to Uniprot (although not mentioned for Homo sapiens species).
CLATHRINGeneProduct1211 (Entrez Gene)
CLEC10AGeneProductENSG00000132514 (Ensembl)
CLEC4GGeneProductENSG00000182566 (Ensembl)
CLEC4MGeneProductENSG00000104938 (Ensembl)
CLEC6AGeneProductENSG00000205846 (Ensembl)
CLTAGeneProductENSG00000122705 (Ensembl)
CLTBGeneProductENSG00000175416 (Ensembl)
CLTCGeneProductENSG00000141367 (Ensembl)
CLTCL1GeneProductENSG00000070371 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CTSBGeneProductENSG00000164733 (Ensembl)
CTSLGeneProductENSG00000135047 (Ensembl)
DAB2IPGeneProductENSG00000136848 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
EPS15GeneProductENSG00000085832 (Ensembl)
ERKGeneProduct
F-ACTINGeneProductENSG00000075624 (Ensembl)
FILAMINGeneProduct
FLNAGeneProductENSG00000196924 (Ensembl)
FLNBGeneProductENSG00000136068 (Ensembl)
FLNCGeneProductENSG00000128591 (Ensembl)
FOLR1GeneProductENSG00000110195 (Ensembl)
Filamin AGeneProduct2316 (Entrez Gene)
Filamin BGeneProduct2317 (Entrez Gene)
Filamin CGeneProduct2318 (Entrez Gene)
GAS6GeneProductENSG00000183087 (Ensembl)
GELSOLINGeneProductA0A0A0MS51 (Uniprot-TrEMBL)
GSNGeneProductENSG00000148180 (Ensembl)
HAVCR1GeneProductENSG00000113249 (Ensembl)
HAVCR2GeneProductENSG00000135077 (Ensembl)
HLA-AGeneProductENSG00000206503 (Ensembl)
HLA-BGeneProductENSG00000234745 (Ensembl)
HLA-CGeneProductENSG00000204525 (Ensembl)
HLA-DMAGeneProductENSG00000204257 (Ensembl)
HLA-DMBGeneProductENSG00000242574 (Ensembl)
HLA-DOAGeneProductENSG00000204252 (Ensembl)
HLA-DOBGeneProductENSG00000241106 (Ensembl)
HLA-DPA1GeneProductENSG00000231389 (Ensembl)
HLA-DPB1GeneProductENSG00000223865 (Ensembl)
HLA-DQA1GeneProductENSG00000196735 (Ensembl)
HLA-DQA2GeneProductENSG00000237541 (Ensembl)
HLA-DQB1GeneProductENSG00000179344 (Ensembl)
HLA-DQB2GeneProductENSG00000232629 (Ensembl)
HLA-DRAGeneProductENSG00000204287 (Ensembl)
HLA-DRB1GeneProductENSG00000196126 (Ensembl)
HLA-DRB3GeneProduct3125 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProductENSG00000198502 (Ensembl)
HLA-EGeneProductENSG00000204592 (Ensembl)
HLA-FGeneProductENSG00000204642 (Ensembl)
HLA-GGeneProductENSG00000204632 (Ensembl)
ICAM2GeneProductENSG00000108622 (Ensembl)
ICAM3GeneProductENSG00000076662 (Ensembl)
IGF1RGeneProductENSG00000140443 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IQGAP1GeneProductENSG00000140575 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProductENSG00000164171 (Ensembl)
ITGA3GeneProductENSG00000005884 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGA5GeneProductENSG00000161638 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB1GeneProductENSG00000150093 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
KPNA1GeneProductENSG00000114030 (Ensembl)
LC8GeneProduct8655 (NCBI Protein)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductMAPK3 (HGNC)
MBL2GeneProductENSG00000165471 (Ensembl)
MERTKGeneProductENSG00000153208 (Ensembl)
MFGE8GeneProductENSG00000140545 (Ensembl)
MHC1GeneProduct"In humans, the HLAs corresponding to MHC class I are HLA-A, HLA-B, and HLA-C." https://en.wikipedia.org/wiki/MHC_class_I
MHC2GeneProduct"In humans, the MHC class II protein complex is encoded by the human leukocyte antigen gene complex (HLA). HLAs corresponding to MHC class II are HLA-DP, HLA-DM, HLA-DOA, HLA-DOB, HLA-DQ, and HLA-DR." https://en.wikipedia.org/wiki/MHC_class_II
NEDD4GeneProductENSG00000069869 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
NFKBGeneProductENSG00000109320 (Ensembl)
NPC1GeneProductENSG00000141458 (Ensembl)
NPC2GeneProductENSG00000119655 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIK3RGeneProductENSG00000145675 (Ensembl)
PP1GeneProduct3.1.3.16 (Enzyme Nomenclature)
PRKRAGeneProductENSG00000180228 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB7AGeneProductENSG00000075785 (Ensembl)
RAB9AGeneProductENSG00000123595 (Ensembl) PUBMED
RAC1GeneProductENSG00000136238 (Ensembl)
RASA2GeneProductENSG00000155903 (Ensembl)
RELGeneProduct5966 (Entrez Gene)
RELAGeneProductENSG00000173039 (Ensembl)
RELBGeneProductENSG00000104856 (Ensembl)
RHOAGeneProductENSG00000067560 (Ensembl)
RHOBGeneProductENSG00000143878 (Ensembl)
RHOCGeneProductENSG00000155366 (Ensembl)
SCINGeneProductENSG00000006747 (Ensembl)
SOCS3GeneProductENSG00000184557 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TIAM1GeneProductENSG00000156299 (Ensembl)
TIMD4GeneProductENSG00000145850 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TOP1GeneProductENSG00000198900 (Ensembl)
TPCN2GeneProductENSG00000162341 (Ensembl)
TSG101GeneProductENSG00000074319 (Ensembl)
TYRO3GeneProductENSG00000092445 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
VPS11GeneProductENSG00000160695 (Ensembl)
VPS16GeneProductENSG00000215305 (Ensembl)
VPS18GeneProductENSG00000104142 (Ensembl)
VPS33AGeneProductENSG00000139719 (Ensembl)
VPS39GeneProductENSG00000166887 (Ensembl)
VPS41GeneProductENSG00000006715 (Ensembl)
VPS4AGeneProductENSG00000132612 (Ensembl)

Annotated Interactions

No annotated interactions

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