Transcriptional cascade regulating adipogenesis (Homo sapiens)

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1Anti-adipogenic Genes of terminal adipocyte differentiationPro-adipogenicGATA2KLF2SREBF1CEBPBKLF15CEBPDEGR2PPARGKLF5CEBPGDDIT3CEBPAGATA3


Peroxisome proliferator-activated receptor gamma (PPARG) lies at the core of the transcriptional cascade that regulates adipogenesis. The expression of PPARG is regulated by several pro-adipogenic (green) and anti-adipogenic (orange) factors. PPARG itself is activated by an as-yet-uncharacterized ligand. CCAAT-enhancer-binding protein alpha (C/EBPA) is regulated through a series of inhibitory protein–protein interactions. Some transcription-factor families have several members that participate in adipogenesis, such as the Krüppel-like factors (KLFs). Rosen et al. Figure 2a

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Ontology Terms



  1. Rosen ED, MacDougald OA; ''Adipocyte differentiation from the inside out.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia


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107570view05:01, 22 October 2019AlexanderPicoModified description
95891view09:49, 2 February 2018Mkutmon
95890view09:49, 2 February 2018MkutmonModified description
95889view09:48, 2 February 2018Mkutmonadded legend
95888view09:46, 2 February 2018MkutmonOntology Term : 'fat cell' added !
95887view09:45, 2 February 2018MkutmonOntology Term : 'signaling pathway pertinent to development' added !
95886view09:43, 2 February 2018Mkutmon
95885view09:42, 2 February 2018MkutmonNew pathway

External references


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NameTypeDatabase referenceComment
CEBPAGeneProductENSG00000245848 (Ensembl) C/EBPα
CEBPBGeneProductENSG00000172216 (Ensembl) C/EBPβ
CEBPDGeneProductENSG00000221869 (Ensembl) C/EBPδ
CEBPGGeneProductENSG00000153879 (Ensembl) C/EBPγ
DDIT3GeneProductENSG00000175197 (Ensembl) CHOP
EGR2GeneProductENSG00000122877 (Ensembl) KROX20
GATA2GeneProductENSG00000179348 (Ensembl) GATA2/3
GATA3GeneProductENSG00000107485 (Ensembl) GATA2/3
KLF15GeneProductENSG00000163884 (Ensembl)
KLF2GeneProductENSG00000127528 (Ensembl)
KLF5GeneProductENSG00000102554 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl) PPARγ
SREBF1GeneProductENSG00000072310 (Ensembl) SREBP1c

Annotated Interactions

No annotated interactions

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