Tumor suppressor activity of SMARCB1 (Homo sapiens)

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253141ProliferationApoptosis suppressionTranscriptionChromatin remodeling / transctiptional regulationRB1Canonical Wnt SignalingARID1ASMARCB1PTCH1RBBP4DPF1SMARCC1SMARCA4SMARCC2SMOGLI1GLI2GLI3GLI4Sonic Hedgehog SignalingSUZ12EEDEZH2Polycomb pathwayH3F3BH3F3AMeMeCell CycleCDKN2ACDK4CDK6G0/G1 transitionACTL6AACTL6BDPF2DPF3SMARCE1SMARCD1SMARCD2SMARCD3ARID1BTranscriptionTranscription


Description

SMARCB1 is a core subunit proteins of the SWI/SNF chromatin remodeling complex, which interact with transcription factors at promoters and enhancers to modulate gene expression. Renal medullary carcinomas have been found to be deficient in SMARCB1 (BAF47) due to mutations. This pathway represents a summary of target genes and pathways implicated in the tumor suppression activity of SMARCB1. This pathway is modeled after figure 2 of "Oncogenic roles of SMARCB1/INI1 and its deficient tumors" by Kohashi and Oda, https://www.ncbi.nlm.nih.gov/pubmed/28109176.

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Ontology Terms

 

Bibliography

  1. Wang X, Haswell JR, Roberts CW; ''Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.''; Clin Cancer Res, 2014 PubMed
  2. Mora-Blanco EL, Mishina Y, Tillman EJ, Cho YJ, Thom CS, Pomeroy SL, Shao W, Roberts CW; ''Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5.''; Oncogene, 2014 PubMed
  3. Kohashi K, Oda Y; ''Oncogenic roles of SMARCB1/INI1 and its deficient tumors.''; Cancer Sci, 2017 PubMed
  4. Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW; ''Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.''; Cancer Cell, 2010 PubMed
  5. Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M; ''Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.''; Nat Med, 2010 PubMed

History

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CompareRevisionActionTimeUserComment
97134view21:01, 30 April 2018KhanspersModified description
97133view20:59, 30 April 2018Khanspersupdated mutation
95846view21:58, 25 January 2018KhanspersOntology Term : 'renal cell cancer pathway' added !
95820view05:37, 22 January 2018KhanspersOntology Term : 'SWI/SNF family mediated chromatin remodeling pathway' added !
95819view05:37, 22 January 2018KhanspersOntology Term : 'sickle cell anemia' added !
95818view05:36, 22 January 2018KhanspersModified description
95817view05:34, 22 January 2018KhanspersModified title
95816view05:32, 22 January 2018KhanspersOntology Term : 'renal carcinoma' added !
95815view05:31, 22 January 2018KhanspersModified description
95814view05:20, 22 January 2018KhanspersModified description
95813view05:19, 22 January 2018KhanspersModified description
95812view05:15, 22 January 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACTL6AGeneProductENSG00000136518 (Ensembl)
ACTL6BGeneProductENSG00000077080 (Ensembl)
ARID1AGeneProductENSG00000117713 (Ensembl)
ARID1BGeneProductENSG00000049618 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK6GeneProductENSG00000105810 (Ensembl)
CDKN2AGeneProductENSG00000147889 (Ensembl)
Canonical Wnt SignalingPathwayWP428 (WikiPathways)
Cell CyclePathwayWP179 (WikiPathways)
DPF1GeneProductENSG00000011332 (Ensembl)
DPF2GeneProductENSG00000133884 (Ensembl)
DPF3GeneProductENSG00000205683 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
GLI1GeneProductENSG00000111087 (Ensembl)
GLI2GeneProductENSG00000074047 (Ensembl)
GLI3GeneProductENSG00000106571 (Ensembl)
GLI4GeneProductENSG00000250571 (Ensembl)
H3F3AGeneProductENSG00000163041 (Ensembl)
H3F3BGeneProductENSG00000132475 (Ensembl)
PTCH1GeneProductENSG00000185920 (Ensembl)
Polycomb pathwayPathway
RB1GeneProductENSG00000139687 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
SMARCA4GeneProductENSG00000127616 (Ensembl)
SMARCB1GeneProductENSG00000099956 (Ensembl)
SMARCC1GeneProductENSG00000173473 (Ensembl)
SMARCC2GeneProductENSG00000139613 (Ensembl)
SMARCD1GeneProductENSG00000066117 (Ensembl)
SMARCD2GeneProductENSG00000108604 (Ensembl)
SMARCD3GeneProductENSG00000082014 (Ensembl)
SMARCE1GeneProductENSG00000073584 (Ensembl)
SMOGeneProductENSG00000128602 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
Sonic Hedgehog SignalingPathway

Annotated Interactions

No annotated interactions

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