Distal Convoluted Tubule 1 (DCT1) Cell (Mus musculus)

From WikiPathways

Jump to: navigation, search
2High PotassiumActiveComplexApical MembranePro-UrinePhosphorylatedProteinACTIVEkir5.1Na+Cl-kir4.1KS-WNK1K+Cl-Low PotassiumWNK4PKinaseScaffoldCab39TerminalKinaseSPAKPWNK1PKS-WNK1Cab39SPAKWNK1WNK4Cl-InactiveComplexKinaseScaffoldTerminalKinasekir5.1CLC-K2kir4.1K+Na+Cl-Apical MembranePCLC-K2Cl-K+Na+Cl-NCCPINACTIVENa+Cl-NCCK+Cl-Cl-


Description

The major function of the distal convoluted tubule 1 cell (DCT1 cell) in the kidney is to maintain proper iron, solute and water homeostasis. The cells are polarized and located in the nephron duct where they have unique transport functions which are maintained by specialized K(+), Na(+), and Cl(-) channels in the proximal or distal part of the cell.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hamilton KL, Devor DC; ''Basolateral membrane K+ channels in renal epithelial cells.''; Am J Physiol Renal Physiol, 2012 PubMed Europe PMC Scholia
  2. Welling PA; ''Roles and Regulation of Renal K Channels.''; Annu Rev Physiol, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106890view13:36, 17 September 2019MaintBotHMDB identifier normalization
104964view13:25, 27 June 2019Fehrhartadded ion fluxes according to Welling et al.
104963view13:18, 27 June 2019FehrhartModified description
104962view13:14, 27 June 2019Fehrhartconnected line
101911view17:09, 16 November 2018EgonwUsed the supported Uniprot-TrEMBL data source name.
95597view00:42, 7 January 2018MaintBotModified title
95362view18:52, 6 December 2017AgustinGV
95361view18:51, 6 December 2017AgustinGValignment
95360view18:50, 6 December 2017AgustinGV
95359view18:44, 6 December 2017AgustinGV
95358view14:23, 6 December 2017AgustinGVModified title
95353view14:10, 6 December 2017AgustinGV
95352view14:10, 6 December 2017AgustinGV
95351view13:55, 6 December 2017AgustinGV
95350view13:53, 6 December 2017AgustinGV
95349view13:36, 6 December 2017AgustinGV
95348view13:23, 6 December 2017AgustinGVOntology Term : 'kidney distal convoluted tubule epithelial cell' added !
95347view13:18, 6 December 2017AgustinGV
95346view13:13, 6 December 2017AgustinGV
95345view13:08, 6 December 2017AgustinGV
95344view13:07, 6 December 2017AgustinGV
95341view20:37, 4 December 2017AgustinGV
95340view20:35, 4 December 2017AgustinGV
95339view20:32, 4 December 2017AgustinGV
95329view13:36, 4 December 2017AgustinGV
95328view13:10, 4 December 2017AgustinGV
95327view13:09, 4 December 2017AgustinGV
95326view13:08, 4 December 2017AgustinGV
95325view13:01, 4 December 2017AgustinGV
95324view12:54, 4 December 2017AgustinGV
95323view12:44, 4 December 2017AgustinGV
95311view19:42, 1 December 2017AgustinGV
95307view19:29, 1 December 2017AgustinGVModified title
95306view19:28, 1 December 2017AgustinGVModified description
95305view19:09, 1 December 2017AgustinGV
95304view19:07, 1 December 2017AgustinGV
95303view19:07, 1 December 2017AgustinGV
95302view18:59, 1 December 2017AgustinGV
95301view18:58, 1 December 2017AgustinGV
95300view18:54, 1 December 2017AgustinGV
95299view18:49, 1 December 2017AgustinGV
95298view18:48, 1 December 2017AgustinGV
95297view18:46, 1 December 2017AgustinGVModified title
95296view18:44, 1 December 2017AgustinGVNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CLC-K2ProteinQ9WUB6 (Uniprot-TrEMBL)
Cab39ProteinQ06138 (Uniprot-TrEMBL)
Cl-MetaboliteHMDB0000492 (HMDB)
K+MetaboliteHMDB0000586 (HMDB)
KS-WNK1ProteinP83741-7 (Uniprot-TrEMBL)
NCCProteinP59158 (Uniprot-TrEMBL)
Na+MetaboliteHMDB0000588 (HMDB)
SPAKProteinQ9Z1W9 (Uniprot-TrEMBL)
WNK1ProteinP83741 (Uniprot-TrEMBL)
WNK4ProteinQ80UE6 (Uniprot-TrEMBL)
kir4.1ProteinQ9jm63 (Uniprot-TrEMBL)
kir5.1ProteinQ9Z307 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Personal tools