RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)

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1, 6, 7, 12, 14...32, 4343322923, 32, 4323, 322318, 323223, 32, 431, 18, 21, 32, 43...23, 323236361, 21, 32, 43, 441, 21, 32, 43, 44143218, 32, 433072932, 34, 43327321, 21, 32, 43, 44321432, 43305, 43platelet alpha granule lumencytosolnucleoplasmH2AFV GATA1 RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1SETD1B MeR206,MeR210-RUNX1 HIST1H4 HIST1H2BN HIST1H2BN HIST1H2BD Me2K5,Me2aR2-H3F3A ITGA2B geneKMT2C Me2K5-H3F3A CBFB EP300 HIST3H2BB HIST1H2BH Nucleosome withH3K4me2Me2K5,Me2aR2-H3F3A H2AFJ SETD1A HIST1H2AJ CBFB HIST2H2AA3 Me2K5-H3F3A HIST1H2BN HIST1H2BN HIST2H2AC H2AFJ SETD1A H2AFJ MIR27A gene SETD1B ITGA2B gene HIST1H2BA HIST2H2AC HIST1H2AD H2AFZ HIST1H2BO KMT2B HIST1H2AD MeR206,MeR210-RUNX1 RUNX1:CBFB:NR4A3geneHIST1H2BJ SIN3B HIST1H2BH HIST1H2BM HIST1H2BH RUNX1:CBFBMIR27A gene HIST1H2BN AdoHcyMe2K5-HIST1H3A KMT2E HIST1H2BH HIST1H2AD HIST3H2BB HIST2H2AC HIST2H2BE PF4 geneSETD1B Me2K5,Me2aR3-HIST1H3A Me3K5-HIST2H3A H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BHIST1H2BB HIST1H2AC KMT2D PRMT6 HIST2H2BE HIST1H2BM KMT2C HIST2H2AC H2AFV Me3K5-H3F3A EP300KMT2C Me3K5-H3F3A Me2K5,Me2aR2-H3F3A HIST1H2AD H2BFS HIST1H2BO HIST1H2AD HIST1H2AD EIF2C4 RUNX1:CBFB:MYL9 geneHIST1H2BD HIST1H2BB NFE2HIST1H2AD HIST1H2BJ Me3K5-HIST1H3A HIST1H2BK HIST3H2BB HIST2H2AC HIST1H2BC DPY30 HIST1H2BA RUNX1 HIST1H4 HIST1H2BN HIST3H2BB H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BHIST3H2BB RUNX1 HIST1H2BM HIST1H2BM RUNX1 HIST1H2BO H2AFV RUNX1 HIST1H2BA Me3K5-HIST1H3A HIST1H2BC HIST1H2AD HIST1H2BM RUNX1 SETD1A CBFB KMT2D Me3K5-HIST2H3A PRMT1 HIST1H2BK SIN3B KMT2C HIST1H2BJ HIST1H2BK PF4H2AFZ H2BFS HIST1H2BO Me2K5-H3F3A HIST1H2BM HIST1H2BM HIST1H2AC WDR5 HIST1H2BK HIST1H2BO CBFB KMT2E RUNX1 HIST1H2AC ZFPM1 H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BHIST1H2AC HDAC1 MYL9HIST1H2BK MIR27A gene HIST1H2BB ITGA2B gene RUNX1 H2AFZ HIST2H2AC AdoMetEP300 PRMT1 PRMT1 SIN3A HIST1H2BM HIST3H2BB RUNX1:CBFB:PRKCQgenePRMT6 Me2K5-HIST1H3A CBFB PF4(32-101) H2AFJ HIST1H2BC HIST1H2AC HIST1H2AJ H2AFX HIST1H2BA HIST2H2AA3 H2AFB1 Me2K5,Me2aR3-HIST2H3A HIST1H2BO H2AFB1 RUNX1:CBFB:NFE2 geneMYL9 gene H2AFV KAT2B HIST1H2AJ H2AFZ RUNX1 HIST1H2BN H2AFB1 ZFPM1 HIST1H2BD HDAC1 KMT2E GATA1 HIST1H2BH H2BFS HIST1H4 HIST1H2BN PF4 gene H2AFZ Me2K5,Me2aR3-HIST2H3A HIST1H2BL ASH2L H2AFJ HIST1H2BB HIST2H2AA3 ASH2L SETD1B HIST1H2BH HIST1H4 KMT2A RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-NucleosomeHIST1H2AD HIST1H2BM HIST1H2AC HIST1H2AJ HIST1H2BN AdoMetH2AFV GP1BAHIST3H2BB KMT2B HIST1H2AJ HIST1H2BO HIST1H2BD RUNX1 H2AFX Me2K5-H3F3A Me2K5-HIST2H3A Me3K5-HIST1H3A Me2K5-HIST2H3A HIST1H2BB ZFPM1 HIST1H2AC HIST1H2BO WDR5 HIST1H2AD Core MLL complexASH2L Me2K5,Me2aR3-HIST2H3A HIST1H2BM HIST2H2BE SIN3B H2AFZ Me2K5-HIST1H3A HDAC1 HIST1H2BK HIST1H2BL HIST1H2BN Me2K5,Me2aR3-HIST1H3A HIST1H2BD H2AFV HIST1H4 H2AFZ HIST1H2BH HIST1H2BL RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1SETD1A HIST2H2BE RBBP5 CBFB THBS1 gene H2AFZ HIST1H2BL ITGA2B gene HIST1H2BH HIST1H2BO HIST1H2BB HIST2H2AC SIN3B HIST1H2BK HIST1H4 HIST1H2AD ZFPM1 HIST1H2BD RUNX1 HIST1H2AJ HIST1H2BC HIST1H2AJ KMT2E HIST1H2BB HIST1H2BB HIST1H2AB DPY30 KMT2D HIST3H2BB KMT2A H2AFB1 H2AFB1 HIST1H2AB H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BITGA2B(32-1039)HIST1H2BO H2AFZ MeR206,MeR210-RUNX1 HIST1H2BB HIST3H2BB H2AFV HDAC1 THBS1 trimerHIST1H2BH HIST1H2AB HIST2H2AC THBS1 gene HIST2H2BE H2AFB1 HIST1H2BK H2AFJ TNRC6A DPY30 PRMT6 HIST1H2BB HIST1H2AJ ASH2L AdoHcyH2AFV HIST1H2AC HIST1H2BB KMT2B GP1BA gene KMT2C RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-NucleosomeRUNX1 RUNX1 miR-27a RUNX1 HIST2H2AA3 HIST2H2BE HIST1H2BJ KMT2E HIST1H2AB RUNX1:CBFB:PRMT1Me2K5-H3F3A HIST1H4 HIST1H2BD HIST1H2BA HIST2H2AA3 HIST1H2BN HIST1H2BL HIST2H2AA3 KMT2E HIST2H2BE RUNX1 RUNX1 HIST2H2BE HIST1H2BO HIST1H2AJ HIST2H2AA3 CBFB PRMT1 SIN3B HIST1H2AB HIST2H2AA3 KMT2E KMT2D H2AFZ AdoMetHIST1H2AB HIST1H2BM HIST2H2AC EP300 PRMT1 SIN3A HIST1H2BL CBFB EP300 H2AFJ Regulation of RUNX1Expression andActivityHIST1H2BJ MeR206,MeR210-RUNX1 HIST2H2AC GATA1 MeR206,MeR210-RUNX1 HIST1H2BL PRMT1 H2AFX HIST1H2AJ HIST1H2BN Me2K5-HIST2H3A Me2K5,Me2aR3-HIST1H3A DPY30 ASH2L HIST1H2AJ SIN3B EP300 WDR5 HIST1H2BK THBS1 gene HIST2H2BE Me2K5-HIST1H3A KMT2B HIST1H4 Me2K5-H3F3A RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-NucleosomeKMT2C H2AFV HIST1H2AJ HIST1H2BJ HIST1H2BK SETD1A ASH2L CBFB Me2K5-HIST2H3A PRMT1 DPY30 RUNX1 HDAC1HIST2H2AA3 Me2K5-HIST1H3A H2AFZ CBFB HIST1H2AJ H2AFB1 HIST1H2AC RUNX1 SIN3A HIST1H2BL HIST1H2BJ CBFB HIST1H2BD H2AFB1 HIST1H2AC HIST1H2BJ KMT2B Me3K5-H3F3A RUNX1:CBFB:PF4 geneHIST1H2BH HIST1H2BC SIN3B CBFB KMT2A HIST2H2BE HIST1H2BB GP1BA gene H2AFZ HIST1H2AB KAT2BMe2K5-HIST2H3A KMT2D PF4(48-101) SIN3B HIST1H2BC ZFPM1 HDAC1 PRKCQ gene HIST2H2AA3 H2AFJ HIST1H2AJ HIST1H2BD GP1BA gene H2BFS HIST1H2AB H2AFB1 Me2K5-HIST2H3A Me2K5-HIST2H3A HIST1H2AJ ITGA2B gene HIST2H2BE H2AFX KMT2C HIST1H2BJ HIST3H2BB HIST1H2BB SIN3B H2BFS H2BFS HIST3H2BB H2AFJ HIST1H2AD HIST1H2BA H2AFB1 HIST1H2AD HIST1H2BD PRMT1 HIST1H2BJ H2BFS GATA1 ASH2L H2AFX HDAC1 HIST1H2BH MOV10 H2AFZ H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH2AFB1 H2AFV SETD1A HIST1H2BA KAT2B SETD1A HIST1H2BC MYL9 geneEIF2C1 DPY30 SIN3A HIST2H2AC KAT2B SIN3A HIST1H2BA RUNX1 HIST1H2BO SIN3A EIF2C3 HIST2H2AA3 HIST1H2BL H2AFX HIST1H2BK HIST3H2BB KMT2B HIST1H2BB NFE2 geneGP1BA geneHIST1H4 MeR206,MeR210-RUNX1 KMT2B Me2K5-HIST1H3A RUNX1 RUNX1 HIST1H2BJ HIST1H2BD H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH2BFS H2AFV HIST2H2AA3 H2AFJ PRMT6 NR4A3 gene HIST1H2BO Me2K5-H3F3A HIST1H2BL HIST1H4 H2AFV HIST1H2BH HIST1H2AC DPY30 NR4A3HIST1H2BH HIST1H2BK H2AFJ RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-NucleosomeH2AFB1 HIST1H2BB H2BFS RUNX1 WDR5 NR4A3 geneSETD1A HIST1H2BO HIST1H4 HIST1H2BJ HIST1H2BD HIST2H2AA3 CBFB HIST2H2BE HIST1H2BA H2AFV HIST1H2BK H2AFX HIST1H2BL HIST1H2BJ RBBP5 H2AFB1 WDR5 HIST1H2BO SIN3A,(SIN3B)HIST1H2BN H2AFJ GATA1 HIST1H2BD Me3K5-HIST2H3A HIST1H2BJ HIST1H2BM H2AFZ PRMT6THBS1 HIST1H2BJ KMT2D MeR206,MeR210-RUNX1 THBS1 gene CBFB RBBP5 Me2K5,Me2aR2-H3F3A H2AFX H2AFZ H2AFX PRMT6 RUNX1 HIST1H2AD SETD1A EP300 H2AFX HIST1H2BL HIST1H2BH HIST2H2AA3 RBBP5 ZFPM1 PRKCQMeR206,MeR210-RUNX1 GATA1 HIST1H2AC HIST1H2BM HIST1H2BC CBFB RBBP5 CBFB H2AFX KMT2A EP300 HIST1H2BD PRMT1CBFB H2AFB1 HIST1H2AB HIST2H2BE H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BHIST1H2AC HIST1H2BK KMT2A Me2K5,Me2aR3-HIST2H3A HIST2H2AC miR-27aNonendonucleolyticRISCSETD1B MeR206,MeR210-RUNX1 MeR206,MeR210-RUNX1:CBFB:PRMT1HIST1H2AJ HIST1H2BJ HIST1H2BD PRMT6 HIST3H2BB RBBP5 SETD1B Me2K5-HIST1H3A HIST2H2BE HIST1H4 TNRC6B H2AFZ HIST2H2BE PRKCQ geneH2AFX HIST1H2BA GATA1 HIST1H2BA H2AFX HDAC1 KMT2C HIST1H2BD HIST1H2BA H2BFS RBBP5 AdoHcyH2AFX H2AFV HIST3H2BB RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-NucleosomePRMT1 H2AFJ HIST1H4 EP300 HDAC1 Me2K5-H3F3A CBFB PRMT6 MIR27A gene HIST1H2BK H2AFB1 KMT2A H2BFS H2BFS HIST2H2AC H2AFZ CBFB HIST1H4 H2AFV HIST1H2BN ASH2L HIST2H2AA3 KAT2B KMT2B THBS1 geneWDR5 KMT2D HIST1H2BB ASH2L NFE2 gene KAT2B HIST2H2BE HIST1H2BL HIST1H2BM SETD1B SETD1B H2AFB1 HIST1H2BC HIST1H2AB HIST1H4 H2AFX HIST1H4 ZFPM1 Me2K5-HIST1H3A GATA1 HIST1H2BJ HIST1H2BH HIST1H2BN KMT2E SIN3A SIN3A KMT2E PRMT1 HIST1H2BA KAT2B CBFB RBBP5 Me3K5-HIST1H3A HIST1H2BM SETD1B HIST1H2AC KMT2A HIST1H2BA MIR27A geneHIST3H2BB Me3K5-HIST2H3A H2BFS CBFB HIST1H2AB PRMT1 CBFB HIST1H2BC HIST1H2BC HIST1H2BA RBBP5 H2AFV H2BFS KMT2B DPY30 HIST1H2BC H2AFJ H2AFJ RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-NucleosomeHIST1H2AD KMT2D HIST1H2AD HIST2H2AC HIST1H2BA H2AFV Me2K5-HIST2H3A HIST2H2AC HIST1H2AC CBFB HIST1H2BC HIST1H2AD HIST2H2BE RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-NucleosomeHIST1H4 HIST2H2AA3 HIST1H2BO HIST1H2BL KMT2A KAT2B Me3K5-H3F3A KMT2C HIST1H2BD SIN3B Me2K5-HIST1H3A HIST1H2BN HIST1H2BM HIST1H2BK HIST1H2AB HIST1H2BN HIST1H2AB WDR5 RUNX1 Me2K5-H3F3A HIST1H2AC HIST1H2BL HIST1H2BL HIST1H2BH CBFB RUNX1 PRMT6 CBFB H2AFX Me2K5,Me2aR3-HIST1H3A GATA1 Me2K5-HIST2H3A H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2BH2AFJ HIST1H2BK H2BFS GATA1:ZFPM1H2AFJ HIST1H2AB HIST2H2AC HIST1H2AB H2AFB1 KMT2D KAT2B H2BFS WDR5 HIST1H2BA GP1BA gene HIST1H2BC KMT2A DPY30 HDAC1 HIST1H2BC SIN3A HIST2H2AA3 HIST1H2BB HIST1H2AC HIST1H2AB HIST3H2BB ZFPM1 CBFB HIST1H2BC HIST1H2BO HIST1H2AB TNRC6C PRMT6 HIST1H2BM MeR206,MeR210-RUNX1 SIN3A WDR5 HIST1H2BL ZFPM1 HIST3H2BB RUNX1 H2AFX H2BFS HIST2H2AC HIST1H2BC HIST1H2BH HIST1H2AJ RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome3232, 4332, 343214364332432172-4, 8-11, 13...32, 4330263232323243322932, 433232, 4332