Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)

From WikiPathways

Revision as of 11:30, 9 August 2017 by ReactomeTeam (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
416312711567, 86, 1321239512272, 24, 117, 130611515745112712257, 124, 13359, 78, 10513, 10931, 71, 11898633, 327443, 4822, 3947, 89, 91, 92, 113...54, 668, 25, 74, 107, 114441, 5, 17, 4027, 28, 120, 122981, 5, 17, 409514, 34, 87, 108, 112...931159974295160, 101, 111, 125, 12610, 16, 35, 68, 85...4, 12, 20, 26, 52...4451, 70, 7227, 12036, 4313157, 124, 1339462, 11853, 742219, 4884, 963056, 64, 12167, 83, 87, 104, 11046, 7780, 1205114, 34, 1129, 21, 23, 33, 37...31, 1183863106, 11911, 42, 69, 103, 11843, 4858, 79, 8118, 65507555, 73, 88, 1005112845, 102endosome lumencytosoltransport vesicle membraneclathrin-coated endocytic vesicle membraneendosome lumensmooth endoplasmic reticulumcytosoltransport vesicle membraneendolysosome membranecytosolclathrin-coated endocytic vesicle membraneendoplasmic reticulum lumenendoplasmic reticulum lumencytosollysosomal lumencytosollysosomal lumenendoplasmic reticulum lumencytosolcytosolendoplasmic reticulum lumennucleoplasmcytosolcytosolcytosolendoplasmic reticulum lumentransport vesicle membranelipid particlePL TAGs PL AP2B1 CHESTCHOL APOA1(25-266) APOC4 PCSK9 CHOLCHEST VLDL:PCSK9:Clathrin:AP2CHOL LIPG dimerenlarged sphericalHDLcholesterol CHOL CHOL PLAPOA2(24-100)VLDLR AP2M1 TAGs GPIHBP1 APOA1(25-266) TAGs TAGs spherical HDL:SR-BIcomplexpre-VLDLAPOB(28-2179) CHOL FACHEST chylomicronremnant:apoEcomplexAP2A2(1-939) PL APOA1(25-266) LDLLDL:LDLR complexAPOA4 cholesterol APOB(28-4563) CUBN CHOL APOC2CHESTCHOL TAG APOBR VLDLcholesterol AP2B1 LDLRAP1PL AP2B1 CHOL PL MTTP PLTP-2 cholesterol esters AP2A2(1-939) CREB3L3(?-461)PL APOC4 LCATAPOA1(25-266) CUBN:AMNAPOA1(25-266) CETP:triacylglycerolcomplexPL APOA1(25-266) spherical HDLNPC1:CHOLCHEST AP2B1 APOB(28-4563) PL pre-beta HDLAPOC3HeparinsLSR APOB(28-4563) APOE LSR cholesterol esters H2OMYLIP dimerCHEST AMN TAGs spherical HDLAPOEADPAP2A1 BMP1-3 CHOLAP2A2(1-939) VLDL (-APOC1,C4)TAGs APOB(28-2179) CHOL TAGs TAGs PALM-CoATAGs LIPC APOC2 CLTC NPC14xPALM-C-ABCA1 APOA1(25-266)PL PL PL A2M APOC3 FURIN APOC3H2OAPOB(28-4563) APOA2(24-100) APOB(28-2179) APOB(28-2179) PL LDLR CES3MTTP CHEST TAGsCLTA VLDLRAPOA4 PL APOB(28-4563) PL ANGPTL3:ANGPTL8APOB(28-4563) Lp(a)ADPClathrin:AP2 complexAPOA1(25-266) pre-beta HDLPLSOAT2 cholesterol esters sphericalHDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-IIILDLR TAGs CHOL CETP APOA1(19-266)AP2S1 TAGs SCARB1-2FGF21 LCAT ATPTAGs TAGs LMF1 NR1H3 4xPALM-C-p-2S-ABCA1 APOB(28-2179) LIPCANGPTL3 APOC4 TAGs TAGs pre-VLDLPL Ub-K839-VLDLRchylomicronremnant:apoE:LDLRcomplexVLDLADPPLAPOC3 TAGs LDLR TAGsAPOC3 CHOLCHEST CLTC PL VLDL:PCSK9APOA1(25-266)MTP:PDI:lipidcomplexPL LPA LDLPL TAGTAGs spherical HDLAPOB(28-4563) LIPA-degraded LDLAPOB(28-2179) PCSK9 PL PL TAGsPLCREB3L3PKA catalyticsubunitAP2A2(1-939) CHEST CHEST CHEST cholesterol esters CHEST TAG DAGsCHOL nascent chylomicronAPOA1(25-266) APOA4,APOA5,APOC2,CIDEC,FGF21 genestorcetrapib APOA4 4xPALM-C-ABCA1tetramer1-acyl LPCLMF1 ATPTAGs CHEST APOA1(25-266) APOB(28-4563) AP2B1 APOB(28-2179)LIPAANGPTL8 cholesterol esters PL PCSK9 VLDLR PL PCSK9 H2Ochylomicronremnant:apoE:LDLRcomplexTAGs SAR1BCETP:cholesterolester complexCHOL CHOL APOBR TAGs MYLIP PL spherical HDLAP2A2(1-939) APOA2(24-100) LDLR PL CoA-SHCHOL CETP:sphericalHDL:torcetrapibcomplexLPL dimeralbumin:2-lysophosphatidylcholine complexPLTP-1 CHEST VLDL:PCSK9:Clathrin:AP2CHOL AP2A1 VLDLR APOC1 chylomicron remnantPL CHOL4xPALM-C-p-2S-ABCA1 CHEST MBTPS1 APOA1(25-266) PL cholesterol CHEST APOB(28-4563) PL discoidal HDLAPOA1(25-266) CLTC CHEST LIPG PL APOC2 APOA1(25-266) LCFAsLIPC dimer:LMF1,2PL APOC2 AP2S1 APOB(28-4563) VLDLR PCSK6 APOB(28-2179)CHOL TAGs APOB(28-4563) AP2M1 CHOL LPL CLTA CHEST CHEST MBTPS1,2ANGPTL4CLTA APOC2 APOE P4HB phosphatidylcholinesNPC2 chylomicronPLCHOL TAGs LCAT:discoidal HDLcomplexAPOB(28-2179) CHOL LPL CHOLDAGsH2OP4HB PCSK9DAGscholesterol estersAPOE CHEST CHOLAP2S1 CHOLCLTC H2OLCFA(-)4xPALM-C-p-2S-ABCA1tetramer:APOA1APOA4 HSPG:LPL dimerAPOB(28-4563)TAGsAPOC4CHOL APOB(28-2179) HSPGAPOE H2OPL PCSK9 PLLIPC dimerCETP APOFPL APOA4 APOC1 LMF1,2PL LPL APOE CHOL CREB3L3(1-?)CHOL FGF21 gene CHEST CHOL LIPC VLDLR4xPALM-C-ABCA1tetramerAPOE HDLBPPL CHOLAPOE TAGs ALB APOB(28-4563) 4xPALM-C-p-2S-ABCA1tetramerCIDEC gene LDLR LDLR CHOLCHEST SOAT1,2APOB(28-4563) CHOL APOC2 gene CHOL PRKACB CLTA APOE LIPC CETP BMP1-3:Zn2+APOC1 Clathrin:AP-2complexAP2A1 LDLRAPOBR dimerTAGs LSR trimerTAGs APOBR dimer:VLDLTAGs CIDEC TAG Clathrin:AP-2complexTAGs TAGs LDLRSOAT1 LPLCHOL APOA1(25-266)APOC3 A2M tetramerCHOL acyl-CoACHEST LDLR TAGs LPAAPOA4 gene CHEST APOC3 AP2A2(1-939) MBTPS2 NPC2PCSK9:LDLR:Clathrin:AP2TAGs APOA1(25-266) CHOL LIPC dimer:heparinPL LCAT:spherical HDLcomplexPL APOA5 gene AP2M1 CHOL PLTAGs sphericalHDL:triacylglycerolcomplexCHEST AP2A1 ABCG1 dimerMTP:PDI:lipidcomplexAP2S1 TAGs ZDHHC8FURIN,PCSK64xPALM-C-ABCA1 APOB(28-4563) PL APOC2APOC2 PL NCEH1TAGs LSR trimerABCG1 APOA1(25-266) LDL:cholesterolester complexTAGs CREB3L3(1-?)LDLR cholesterol esters ABCA1 APOA4,APOA5,APOC2,CIDEC,FGF21AP2B1 APOA1(25-266) LDLAP2M1 APOA1(25-266) APOA1(25-267)CHESTAPOE PL CLTC AP2B1 TAGs APOA2(24-100) CHEST APOA1(25-266) HDLBP:HDLCoA-SHcholesterol esters CHESTGPIHBP1cholesterol esters LDLR PLTPAPOA1(25-266) TAGsTAGs TAGs chylomicronremnant:apoE:LDLRcomplexTAGs AP2S1 APOA1(25-266) LMF2 PL AP2S1 TAGs PiAPOA4PCSK5LCATCHOL torcetrapibAPOA5CHEST GPIHBP1:HSPG:LPLdimerdiscoidalHDL:cholesterolPL PL AP2M1 Heparins PL CHOL NPC2:CHOLSCARB1-2 CHEST PL LDL:LDLR complexCHOL LDLR1-acyl LPC LDL:LDLR complexAP2S1 AP2A2(1-939) HSPG PCSK9:LDLR:Clathrin:AP2PCSK9:LDLRLMF2 PL PL LSR TAGs APOECHOL ALBTAGsLSR LDLRAP1APOA1(25-266) NPC1 PL nascent chylomicronPL NR1H2,NR1H3CHOLPRKACA ApoB-48:TG:PLcomplexPCSK9 APOC1 APOC1APOB(28-4563) APOC4 HSPG PL AP2A1 APOA2(24-100) PL cholesterol esters APOB(28-4563) VLDL:VLDLRCHOL CHEST APOB(28-4563) PL CHEST Zn2+ APOA1(25-266) NR1H2 FAsAP2A1 APOB(28-2179) APOA4 TG-depletedchylomicronAP2M1 cholesterol PiLSR trimer:LDLAPOB(28-2179) CHOL TAGs PCSK9ANGPTL3PRKACG CHESTApoB-48:TG:PLcomplexAP2M1 APOA2(24-100) CHEST ATPTAGs APOA5 APOE PL CLTC APOA1(25-267) CHOL sphericalHDL:apoC-II:apoC-III:apoECUBN LCAT LCFAscholesterol esters CLTA AMN sphericalHDL:apoC-II:apoC-III:apoECHOL TAGs APOB(28-2179) AP2A1 CLTA CHOLAPOC2 CHEST apoA-I:CUBN:AMNcomplexCHOL LIPC CHOL CLTC LIPC dimerCHOL APOB(28-2179) APOB(28-4563) chylomicronremnant:apoEcomplexAPOA1(25-266) APOA1(25-266) LSR trimer:VLDLANGPTL8cholesterol ABCA1 tetramerLDLRCHEST PL CLTA HDLBP 34411311311311311311313413113113113194131131