Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)

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11010412853, 105, 11224, 26, 68, 69, 1224016, 4638, 77, 1224111035127122, 1291101851, 91, 976479, 1101216, 4628, 30, 8429, 34, 48, 89, 94...4092401187152, 59, 727410250, 1147, 22, 9310, 853540, 75, 7613, 23, 108, 13444, 11320, 25, 73, 11911821, 42, 45, 6137, 702, 65, 12635, 54, 99, 12112512813, 23, 108, 1341182, 65, 126419, 15, 60, 62, 678057103, 116718, 32, 55, 110, 1235738, 1229556, 10716, 78714043, 463918, 3614, 5428, 30, 49, 66, 84...864, 7, 63, 117, 1331, 331158858, 98115, 6, 17, 82, 120...12431, 87, 90, 106, 109...54, 993, 19, 27, 47, 81...102cytosolcytosolendoplasmic reticulum lumenendoplasmic reticulum lumencytosolnucleoplasmlysosomal lumencytosollysosomal lumencytosolcytosolendoplasmic reticulum lumensmooth endoplasmic reticulumcytosolclathrin-coated endocytic vesicle membranecytosoltransport vesicle membraneendosome lumenendolysosome membraneendosome lumenlipid dropletcytosolendoplasmic reticulum lumencytosolendoplasmic reticulum lumenclathrin-coated endocytic vesicle membranetransport vesicle membranetransport vesicle membraneCHEST cholesterol esters TAGsAPOB(28-4563) APOA2(24-100)PL APOC2 chylomicronAPOC1 AP2A1 LCATTAGs LPAAPOE VLDLRTAGssphericalHDL:apoC-II:apoC-III:apoECETP:triacylglycerolcomplexLCAT PL CETP LCAT:discoidal HDLcomplexspherical HDLTAGs TAGs APOC1 AP2A2(1-939) CREB3L3(1-?)ALBPCSK9 APOA2(24-100) APOC1 LDL:LDLR complexAPOBR dimerFATAGs VLDLR CHOL1-acyl LPC TAGsCHEST CLTA PRKACG APOB(28-2179)SCARB1-2 LCFA(-)AP2B1 TAGs Zn2+ PL PRKACB HSPGpre-VLDLTAGs 1-acyl LPCSOAT1 AP2B1 CETP CHOL ANGPTL3 LPL PLCHOL LDLPL APOB(28-4563) CHOL APOC4 ANGPTL3:ANGPTL8H2OCHEST APOC4 CHEST APOB(28-4563) MBTPS1 cholesterol esters TAGs CHOL APOA4 sphericalHDL:apoC-II:apoC-III:apoE4xPALM-C-ABCA1 APOB(28-4563) PL APOA1(25-266) LSR AP2M1 cholesterol TAGs LIPC TAGs AP2A1 PL BMP1-3 PCSK9 CHOL LDLRAP2M1 CLTA APOA1(25-266) 4xPALM-C-ABCA1 MTTP PL AP2S1 PLH2OAPOA4 HSPG:LPL dimerAP2B1 APOB(28-4563) P4HB APOE CHOL CHOL APOC3 LSR H2OApoB-48:TG:PLcomplexCHOLalbumin:2-lysophosphatidylcholine complexAP2B1 TAGs CHOL LDLRAP1LDLRAPOC1LIPC dimer:heparinAPOA1(25-266) PL AP2A2(1-939) APOB(28-4563) APOB(28-4563) ANGPTL8 CHOL APOA1(25-266) HeparinsLDLR PL LDLCHOLVLDL:PCSK9:Clathrin:AP2TAGs SOAT2 PCSK6 MTP:PDI:lipidcomplexphosphatidylcholinesLDL:LDLR complexPL NPC1 AP2M1 CIDEC gene APOB(28-2179) FAsPL CHOLPL AP2S1 LIPC dimerCHOL torcetrapib 4xPALM-C-p-2S-ABCA1 VLDL:PCSK9TAGs AP2S1 PCSK9:LDLR:Clathrin:AP2P4HB CHOL LPLCHEST VLDL (-APOC1,C4)VLDLAPOC3 APOA1(25-266) TAGs NPC1:CHOLAPOB(28-2179) APOA4,APOA5,APOC2,CIDEC,FGF21cholesterol APOB(28-4563) APOB(28-2179) CLTC APOB(28-2179) PiNPC2CREB3L3DAGsLIPAAPOB(28-2179) APOE LSR trimer:VLDLLIPG CHEST pre-VLDLLIPC GPIHBP1 AP2A2(1-939) Ub-K839-VLDLRLPL APOB(28-4563) APOC3 APOB(28-2179) PL CUBN ADPNR1H3 LPL NPC2 CHEST TAGs NR1H2 AP2A2(1-939) APOB(28-2179) CHEST PLHDLBP:HDLPL HSPG PL CHOL CHEST TAGs TG-depletedchylomicronA2M tetramerCHOL CHEST AP2A2(1-939) Clathrin:AP-2complexcholesterol esters APOA4 APOBR CHEST TAGs APOE 4xPALM-C-p-2S-ABCA1tetramerCREB3L3(1-?)CHOL AP2A1 APOA1(25-266) TAGs PLHSPG APOE APOA1(25-267) nascent chylomicronTAGs APOC3 PL PL TAGs APOA1(25-266) spherical HDLAPOE GPIHBP1CHEST LDLR TAGs LSR PCSK9CHEST CHOL APOA4CLTC LCAT CHEST CHEST CLTA APOB(28-4563) PRKACA PL CHEST APOFCHESTLMF1,2cholesterol esters PL TAGs MYLIP dimerAPOA1(25-266) TAG PL CHOL LIPG dimerCHOL LDLAPOB(28-2179) SAR1Bcholesterol NPC2:CHOLCLTA VLDLAPOA1(25-266) AP2S1 APOA5 PCSK5APOA4 APOA1(25-266)LIPC APOA1(25-266) CHOL discoidal HDLPLLDLR AP2A1 H2OLSR trimer:LDLCHEST APOC2 spherical HDL4xPALM-C-ABCA1tetramerLp(a)TAGs CES3ApoB-48:TG:PLcomplexAPOA1(25-266)VLDLR ZDHHC8PL CLTA APOB(28-4563) APOECHOL CLTA APOA4 gene TAGs LCFAstorcetrapibCHOLCLTC LMF1 TAGs APOA4 CHEST CHESTPL VLDL:VLDLRHDLBPPL cholesterol estersLDLR APOB(28-4563) APOB(28-2179)APOA1(25-266) CHEST TAGs TAGs APOA1(25-266) AP2S1 cholesterol esters APOA1(25-266) PKA catalyticsubunitCHOL CHOL CHOL CHEST CHOL ANGPTL8CLTC APOB(28-4563) MYLIP CHOL APOE LSR trimerAPOA4,APOA5,APOC2,CIDEC,FGF21 genesAP2B1 CHOLMBTPS2 APOA1(25-266) TAGs DAGsAPOC3 APOB(28-4563) PCSK9:LDLRLCATAP2M1 LCAT:spherical HDLcomplexAPOC1 CHOLABCG1 dimerCHEST APOBR CLTC AP2A1 LDLRAP1HDLBP CHOLVLDL:PCSK9:Clathrin:AP2CHEST LPL dimerCHOL FURIN CLTC CHOL APOA1(25-267)ABCG1 cholesterol esters TAG sphericalHDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-IIITAG MTTP Clathrin:AP2 complexPL PLTP-2 APOC2 CHOLAPOE CHEST TAGs 4xPALM-C-p-2S-ABCA1tetramer:APOA1ATPacyl-CoApre-beta HDLHeparins LDLR LIPCCHEST enlarged sphericalHDLLSR PL MTP:PDI:lipidcomplexCHOL CREB3L3(?-461)APOA2(24-100) CETP:sphericalHDL:torcetrapibcomplexPL APOA1(25-266) PL CHEST AP2M1 VLDLR LDLRPL TAGs cholesterol CHEST TAGs PALM-CoATAGs PL PL TAGs cholesterol PL NCEH1CHOL CHOL LDLRAPOC4 APOA1(19-266)H2Ochylomicronremnant:apoE:LDLRcomplexAPOB(28-2179) AP2A2(1-939) CHESTspherical HDL:SR-BIcomplexAP2A2(1-939) LMF2 PL APOA2(24-100) TAGs PL APOC2 gene CHOL AMN APOC2ANGPTL4TAGsPL FGF21 PL APOA1(25-266) APOA1(25-266) CHOL CETP:cholesterolester complexchylomicron remnantADPCHOLCHESTPL pre-beta HDLAPOA1(25-266) LIPC dimer:LMF1,2APOC4 SCARB1-2TAGs AP2A1 FGF21 gene sphericalHDL:triacylglycerolcomplexcholesterol esters spherical HDLAPOA1(25-266) APOC2 PCSK9 CHOL APOC4APOELDLR APOA5APOB(28-2179) PL PL CHESTSOAT1,2PL PCSK9CUBN:AMNPCSK9 TAGsLIPC dimerBMP1-3:Zn2+PLTP-1 PL CIDEC APOA5 gene apoA-I:CUBN:AMNcomplexCHOLTAGs CHEST FURIN,PCSK6LSR trimerNR1H2,NR1H3CoA-SHAPOC3PL AMN VLDLR APOB(28-4563) PL APOB(28-2179) APOC2 GPIHBP1:HSPG:LPLdimerAP2M1 CHOL AP2S1 CETP LIPC A2M PLTAGs AP2M1 cholesterol esters TAGs LCFAsAP2S1 ATPPL LIPA-degraded LDLANGPTL3APOB(28-4563)PL LDLR cholesterol TAGsCLTA APOC2CLTC ABCA1 tetramerLPA TAGs CoA-SHCHEST CHOL AP2B1 APOA2(24-100) APOA4 TAGs PLTPchylomicronremnant:apoEcomplexLDL:cholesterolester complexPL ABCA1 PiCHEST APOA1(25-266) nascent chylomicronPLCHOL MBTPS1,2APOA1(25-266) LDLR APOB(28-4563) ALB PCSK9 LMF1 APOA1(25-266)LDLR 4xPALM-C-p-2S-ABCA1 TAGLMF2 APOB(28-2179) CHOL CHEST PL CHEST PCSK9:LDLR:Clathrin:AP2PL CHOL APOA2(24-100) APOB(28-4563) APOBR dimer:VLDLTAGs chylomicronremnant:apoE:LDLRcomplexAPOA1(25-266) AP2B1 TAGs APOB(28-4563) APOE CHOL ATPTAGs APOC2 CUBN PL ADPLDL:LDLR complex4xPALM-C-ABCA1tetramerNPC1chylomicronremnant:apoE:LDLRcomplexPL cholesterol esters PL CHEST Clathrin:AP-2complexAPOE APOC3APOA1(25-266) AP2A1 CHOL VLDLRH2Ochylomicronremnant:apoEcomplexPL TAGs PL discoidalHDL:cholesterolPCSK9 DAGsCHOL 281241248612412412412412412412428124125124124