Cilium Assembly (Homo sapiens)

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7, 9, 27, 43, 55...5, 61, 67, 1533, 21, 31, 38, 56...70, 1096928, 51, 56, 104, 122...33, 63, 64, 68, 106...16, 55, 58, 80, 85...8, 13, 21, 29, 42...19, 69, 1133, 16, 21, 31, 74...1, 18, 48, 53, 57...47, 52, 58, 106, 120...33, 63, 64, 68, 106...64, 107, 1099, 30, 59, 61, 90...2, 116, 128, 1532, 24, 116, 128, 144616912, 13, 35, 74, 75, 81...23, 39, 8526, 50, 82, 85, 105...4, 14, 16, 18, 48...38, 48, 56, 65, 78...16, 74, 13753109, 14138, 55, 118, 1276, 20, 22, 37, 84...33, 63, 64, 68, 106...56, 104, 12217, 61, 66, 86, 92...58, 120, 127, 146, 15411, 44, 49, 72, 103...11, 49, 62, 103, 112...64, 10938, 54, 56, 79, 94...10, 1546, 15, 20, 22, 32...2, 9, 40, 41, 73...16, 55, 85, 127, 147...5, 9, 30, 34, 46...25, 38, 51, 56, 104...5, 52, 67, 135, 150...19, 69, 11389, 95, 111, 1243, 16, 27, 112, 1371093, 16, 31, 38, 56...56, 106, 136Golgi-associated vesicleciliumGolgi-associated vesicleGolgi-associated vesicleGolgi lumenendoplasmic reticulum lumencytosolWDR35 EXOC8 ASAP1 KIF3B TUBB4B CEP72 acetylatedmicrotubuleCEP135 DYNLL1 CCP110 YWHAG TUBA4A TUBA4A CEP290 TCTE3 RAB3IP RP2:ARL3:GTP:UNC119BASAP1 CNGB1 CEP57 SDCCAG8 TUBG1 KIF3A IFT74 DYNLL1 CC2D2A ASAP1 dimerRHO Golgi-derived vesicle PAFAH1B1 HAUS5 HAUS7 HAUS3 KIF24 B9D1 TCTN1 BBS4TUBA4A ARL6 TUBG1 PKD2 HAUS3 ARF4 RAB11FIP3 HSP90AA1 CEP41 NEK2 AHI1 TCTEX1D1 CEP78 PCM1 TUBB IFT74 RAB11A DCTN1-2 PRKAR2B OFD1 myristoylatedciliary cargoCLASP1 IFT20 SMO CEP78 BBS9 ARL3:GTP:UNC119B:myristoylated ciliary cargoTUBA4A CLUAP PPP2R1A IQCB1 RAB8A:GTPCEP76 GTP BBS2 SDCCAG8 TUBG1 acetylatedmicrotubulePKD2 DCTN2 ARF4 CEP83 BBS2KIF17 dimer:TNPO1NINL DCTN3 RAB8A RAB3IP BBS/CCT complexTCTE3 KIFAP3 DYNC2H1 HAUS5 WDR19CEP76 IFT20 SFI1 CDK1 AZI1 CEP83 PPP2R1A CSNK1E EXOC1 IQCB1 CNGA4 PRKAR2B GTP BBS5 CEP89 CEP83 TUBA4A IFT74 TUBB AKAP9 TUBB DCTN1-2 DCTN2 CSNK1D ODF2 BBIP1 IFT172 OFD1 IFT46 CEP78 MyrG2-NPHP3 TTC30B TTC30A HSPB11 SSNA1 CETN2 EXOC5 PKD1 IFT46 C2CD3 NEDD1 CEP57 RAB11FIP3 TUBB YWHAG CNGB1 HAUS2 GTP TCTE3 BBS9DYNLRB1 CLASP1 TTC26 DYNLL1 YWHAE WDR34 NPHP complexHAUS6 TUBG1 CETN2 PRKACA IFT140 CSNK1D IFT122RPGRIP1L KIF17 dimerCEP41 NINL CLASP1 KIFAP3 CEP250 mother centrioleCEP97HAUS4 EXOC5 YWHAG IFT88 CETN2 TMEM216 IFT74RP2 IFT27 RAB11A IFT27 TCTEX1D2 CEP70 PDE6D:INPP5EWDR19 CEP290 BBS9 TTC26 TCTN3 CLUAP WDR19 DCTN3 NINL IQCB1 INPP5EDYNC1I2 MicrotubuleFGFR1OP IFT122 TTC30A CEP57 CDK5RAP2 MAPRE1 UNC119B IFT BWDR60 IQCB1 CCT8 FGFR1OP CNGA4 dynein-2TTC30B IFT57 YWHAG RABL5 Tectonic-likecomplexCSNK1D PKD1 TTC30A BBS4 HAUS4 UNC119B NINL RAB11A TUBA1A SCLT1 IFT52 WDR19 PKD1 MyrG2-NPHP3 ARF4 DYNLL2 RP2 TUBB4B CEP97 EXOC6 CEP78 IFT43 HSPB11 PKD1 TMEM67 DYNLRB2 YWHAE NPHP4 TTC8ARF4 TCTE3 PAFAH1B1 TUBB4B AZI1 PAFAH1B1 DYNC2LI1 BBIP1CEP164 TRAF3IP1 IFT88TRIP11CEP72 DCTN3 IFT BPKD2 TCTEX1D1 NEK2 LZTFL1 oligomerTMEM67 IFT B*DYNC2LI1 BBS2 VxPx-containingciliary membraneproteinsIFT52 EXOC8 OFD1 CEP290 BBS1 HSPB11 LZTFL1oligomer:BBSomeCEP152 CENPJ CNTRL PDE6DCEP41 KIF24 CNGA4 CNGB1 CKAP5 ODF2 TUBG1 DYNLRB1 CEP152 CEP152 KIF24 HAUS7 CEP250 CEP192 ODF2 CEP72 TUBA1A CEP63 KIF3A RPGRIP1L CSNK1E TCTEX1D2 PAFAH1B1 RAB3IP:BBSomeTTBK2HSPB11 CEP89 DCTN1-2 WDR60 HAUS6 RAB3IP:RAB11A:GTP:Golgi-derived vesicleGDP CDK1 DYNC2H1 ACTR1A IFT88 ARL13B:INPP5E:PDE6DPLK1 DCTN3 CEP290 HAUS8 IFT140 CEP97 MKS1 FBF1 CEP72 KIF3C UNC119BEXOC4 CEP162 TRAF3IP1DCTN2 PCM1 IFT57 RAB11A CEP70 RAB3IP IFT74 PLK1 CEP250 PPP2R1A CENPJ HAUS2 CLUAP BBS7 ATATHAUS7 DYNC2LI1 KIF3B MAPRE1 NINL CEP63 KIF17 PLK4 RAB11A CEP250 RAB3IPWDR60 TCP1 FBF1 exocystcomplex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteinsPPP2R1A NEK2 TTC21B SDCCAG8 TCTN2 Centrosome:C2CD3:distal appendage proteins:TTBK2B9D1 AKAP9 CDK1 CNGA2 GTP PRKACA CKAP5 DYNC1H1 CNGA2 CDK5RAP2 HAUS4 CENPJ B9D2 TTC30A HAUS8 AZI1 EXOC7 KIF17 dimer:TNPO1IQCB1 PDE6D TTC26 IFT27 IFT74 CSNK1E RP2:ARL3:GDP:UNC119BBBS1 OFD1 RHO IFT80 WDR19 TTC8 KIF3A BBS10 DYNC1H1 NEK2 PPP2R1A PKD2 WDR60 RAB3IPALMS1 KIF17 TCTE3 ARL3:GDPPAFAH1B1 TUBA4A TTC21B IFT52 HAUS8 PCNT DYNC1I2 CEP41 RABL5 SDCCAG8 H2OAKAP9 CEP135 ASAP1 RAB3IP:RAB8A:GDPCEP57 KIF17 UNC119B DYNLL1 SDCCAG8 SSNA1 BBS9 CEP192 CEP152 GTP ALMS1 ACTR1A HAUS3 CETN2 HAUS8 CEP89GTPDYNLRB2 RAB11FIP3 ARL13B:INPP5EIFT57RAB11FIP3 PKD1 CNGA4 DYNLRB1 CDK1 MAPRE1 NPHP4 CEP76 SFI1 TTC30A SMO INPP5E TUBB4B PLK4 NEDD1 CENPJ NINL ACTR1A YWHAE TTBK2 CNTRL DCTN2 MARK4 PRKACA SEPT2TTC30B CSNK1D BBS7 CDK5RAP2 TTC30B HAUS6 IFT81 RHO PLK4 IFT172 ARF4:GTP:VxPx-containing ciliary membrane proteinsKIF3B CEP162 anterograde IFTtrainsCNGA2 CNTRL CCP110 CCP110 PRKAR2B HAUS3 CKAP5 CEP70 IFT43CEP76 CKAP5 ARL6 CEP250 CSNK1E NEK2 CEP290 IFT88 CCP110 KIF3B ALMS1 GTP CEP164 TUBA1A TRAF3IP1 WDR60 ASAP1 MAPRE1 WDR35 NDE1 HAUS5 IFT27 PRKAR2B CEP72 KIF24 INPP5E TTC26 CEP83 CNGB1 ALMS1 RAB11A GTP OFD1 SFI1 ALMS1 DYNC1I2 DYNC1I2 CEP192 DYNC2LI1 SSTR3 CNGA2 ACTR1A RAB8A CEP162 IFT172 GTP ALMS1 NPHP4 CEP162 IFT122 CNGB1 FBF1 IFT52 CNTRL PKD1 TUBB4A SFI1 SFI1 ASAP1 KIF3B RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteinsCLUAP BBIP1 TTC30B SSNA1 KIF3B KIF24 BBS5UNC119B ALMS1 TUBG1 TUBB4A IFT20 GDP TCTEX1D1 RHO RAB11A:GTP:RAB11FIP3dimer:ASAP1dimer:ARF4:GTP:VxPx-containing ciliary membrane proteinsEXOC2 C2CD3 CEP164 CEP78 PKD1 CLASP1 PKD2 CEP72 acetylated microtubule GDP RAB3IP PLK4 NPHP1 CC2D2A CLUAPDYNC2H1 CNGA4 MCHR1 AKAP9 CEP57 CNGA2 DYNLL1 PKD2 AKAP9 TUBA1A MCHR1 KIF17 CEP63 MKS1 EXOC3 HAUS3 ODF2 IFT43 CEP57 CEP76 CNTRL HAUS8 CDK5RAP2 PKD1 HAUS2 PRKACA GDP DCTN3 CLUAP PCNT HAUS2 IFT122 ARL3 RAB11FIP3 WDR19 TUBB4A IFT46 RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteinsTTC21B PLK1 HAUS6 AKAP9 CNGA2 DYNLL1 TCTEX1D1 ARL3 TCTEX1D1 TRIP11 CDK5RAP2 PCNT OFD1 SSTR3 TUBB AZI1 IFT74 HAUS2 acetylated microtubule protofilament CEP152 CNGB1 RAB8A exocyst complexCEP70 DYNC1H1 GTP WDR35 GTP PDE6D GTPCNGA2 IFT20 TTC30B TUBB4B MARK4 SCLT1 CNGA2 IFT43 CNGA4 ARL6 TTC26 ARF4 KIF17 CDK1 IFT140YWHAG YWHAE RAB8A:GDPNDE1 IFT57 IFT20GBF1BBIP1 TRAF3IP1 DCTN2 TTC8 NEK2 CNTRL MyrG2-NPHP3 SCLT1CEP70 IFT80 BBS1 CEP152 DYNLL1 PLK4 CENPJ DYNC1H1 CENPJ HSP90AA1 TNPO1 GDP NPHP1 CNGB1 IFT46ACTR1A MCHR1 TUBA1A DCTN2 UNC119B:myristoylated ciliary cargoTUBB EXOC4 YWHAE ARL6:GTP:BBSome:ciliary cargoPLK1 CEP72 CEP135 MAPRE1 NDE1 YWHAG IFT122 TMEM216 PDE6D IFT81 CEP83 OFD1 Kinesin-2 motorsCEP250 IFT57 C2CD3 Kinesin-2 motorsDYNC2H1 EXOC3 IFT20 CKAP5 DYNLL2 TTC8 DYNC1I2 GTPFGFR1OP KIF24 retrograde IFTtrainsTTC30B CEP41 CEP97 DCTN1-2 KIF24 TUBG1 HSP90AA1 YWHAG HAUS2 DYNLL1 BBSome ciliary cargoHAUS5 CEP72 Golgi-derived vesicle CEP63 HSPB11 acetylated microtubule ALMS1 PRKACA CNGB1 HAUS3 KIF17 HAUS5 IFT81 DYNLL1 MAPRE1 SCLT1 NEK2 PCNT BBS7 TCTE3 NEDD1 ARL13B BBS5 CEP290 DCTN2 IFT52 HAUS4 SSNA1 MyrG2-CYS1 BBIP1 active kinesin-2motorsCKAP5 HAUS3 DCTN1-2 TTC8 CEP78 CLUAP HAUS1 IFT80RAB11A:GTPCEP89 IQCB1 KIF3A HAUS1 MyrG2-CYS1 acetylated microtubule NPHP1 RP2:ARL3:GTP:UNC119B(active)KIF3B CSNK1D CEP152 SCLT1 PLK1 GDPCEP162 CEP135 TTBK2 UNC119B:myristoylated ciliary cargoSDCCAG8 PPP2R1A TTC30A DCTN3 TTBK2 CSNK1E HAUS7 IFT80 TTC30B CEP97 RAB11A KIF17 CEP164 DYNLRB2 DYNC2LI1 DYNLRB2 CEP250 NEDD1 SDCCAG8 MyrG2-CYS1 RAB11A Piacetylated microtubule GTP TRAF3IP1 DYNC1H1 IFT172CEP152 HAUS1 CCP110 CEP162 MKS1 basalbody:transitionzone proteinscentrosome:C2CD2:distal appendage proteins:TTBK2:MARK4PCNT WDR60 CEP290 CETN2 NDE1 CCP110CETN2 MAPRE1 WDR35 FBF1 CLUAP DCTN3 HAUS7 CEP78 IFT81 TUBG1 AHI1 AZI1 CCT2 HAUS2 IFT122 BBS1 NDE1 TUBB4B TRAF3IP1 CLASP1 KIFAP3 IFT80 SFI1 anterograde IFTtrainsNEK2 BBS9 Golgi-derived vesicle CCT4 TTC30WDR34 IFT46 CC2D2A PAFAH1B1 YWHAE CNGB1 PLK1 RAB11A CCT5 PKD2 PAFAH1B1 TTBK2 AZI1 GDPMyrG2-CYS1 IFT74 TUBA1A EXOC1 CETN2 OFD1 IFT27YWHAE GTP RAB11FIP3 dimerIFT46 B9D2 FGFR1OP TCTE3 HAUS1 TUBB4A KIF24 TTC8 HAUS5 GTP PRKACA basalbody:transitionzoneproteins:RAB3IP:RAB11A:GTP:Golgi-derived vesiclePCNT CEP250 RAB11FIP3 ASAP1dimer:ARF4:GTP:VxPx-containing ciliary membrane proteinsCEP97 RAB3IP GTP AHI1 ARL6:GTPFGFR1OP HAUS3 IFT20 retrograde IFTtrainsB9D1 CENPJ HAUS1 NDE1 HSP90AA1 RP2 CEP76 DYNLL1 TUBA1A IFT20:TRIP11HAUS1 SSTR3 IFT43 CNGA2 TUBB PCM1 IFT52 CEP89 TCTEX1D2 TCTEX1D2 IFT46 PAFAH1B1 EXOC2 MyrG2-NPHP3 B9D2 SCLT1 ARL3 MyrG2-NPHP3 CEP70 TUBB4A CEP41 DCTN1-2 ARL13B IFT172 NINL RHO BBS5 CNGA4 KIFAP3 TTC30A SFI1 ASAP1 BBS4 CDK1 TUBA1A WDR35 MKKS HAUS6 BBS4 DYNLL2 ARL3 ODF2 IFT80 ARL6:GTP:BBSome:ciliary cargoWDR60 TCTN1 TCTEX1D2 HAUS6 ODF2 HAUS4 IQCB1 CNTRL DYNC1H1 RHO DYNC1H1 HAUS6 KIF3A TUBA4A CKAP5 WDR34 TUBA4A GTP BBS2 IFT43 RAB3IP RPGRIP1L CEP76 CEP70 AZI1 CENPJ GTP BBS5 DYNC2H1 AKAP9 IFT81 BBS4 HSPB11ARF4:GTPHAUS8 CEP192 NEDD1 CDK1 PRKAR2B KIF3C TMEM216 TRAF3IP1 DYNC1H1 CEP164 CEP162 IFT88 CEP83TUBB4B WDR35 CEP63 BBIP1 INPP5E dynein-2IFT140 TTC30A KIFAP3 DYNLL2 TTC26 DCTN1-2 YWHAG CEP57 ACTR1A SSNA1 IFT140 WDR34 CEP192 PDE6D:INPP5ERAB8A GTP DYNLRB1 MARK4 mothercentriole:C2CD3PPP2R1A DYNLL1 ARL3 PCM1 Microtubule protofilament DYNLRB2 RHO TNPO1TMEM67 FBF1 GTP HAUS2 IFT80 ASAP1 TTBK2 TTC26IFT172 RAB11A:GTP:RAB11FIP3dimer:ASAP1dimer:VxPx-containing ciliary membrane proteinsCSNK1D CEP162 HAUS7 CCT3 IFT88 GTP CEP63 PPP2R1A RAB8A RABL5 CNGA4 DYNLRB1 ARL3 IFT46 IFT27 DYNLL1 CEP83 KIF3C IFT80 FBF1NDE1 DCTN3 CEP135 PLK4 ARL3 UNC119BDYNC1I2 CEP164 HAUS4 IFT88 GTP TCTN3 IFT20 HSP90AA1 CEP63 HAUS4 SDCCAG8 CEP41 KIFAP3 CLASP1 DYNC1I2 MAPRE1 CEP70 CEP192 PKD2 PCM1 FBF1 NDE1 MARK4WDR34 FGFR1OP CSNK1E ARL3:GTPC2CD3 DYNC2LI1 ARL3:GTP:UNC119BRAB11FIP3 C2CD3CEP78 PKD2 DYNC1I2 RP2DCTN1-2 WDR19 myristoylatedciliary proteinsDYNC2LI1 HSP90AA1 CKAP5 PCM1 BBS7 VxPx-containingciliary membraneproteinsIFT88 IFT122 C2CD3 IFT27 KIF3C CEP135 HDAC6Ac-CoASCLT1 KIF17 DYNC2H1 MARK4 CEP57 KIF3A C2CD3 C2CD3 MyrG2-CYS1 TNPO1 IFT81PRKAR2B PLK4 IFT140 CEP76 HSP90AA1 SSNA1 NEDD1 IFT81 HSP90AA1 PCNT RAB11A:GTP:Golgiderived vesicleBBS12 CETN2 ARL13BIFT ABBS7RABL5 HAUS7 NEDD1 CEP135 DYNLRB1 PCNT CLASP1 IQCB1 ODF2 DYNC2H1 CDK5RAP2 TTC26 CEP63 PCM1 PRKACA TUBB4B CoA-SHDYNLL1 IFT57 IFT57 DYNLRB2 GDP CSNK1D CEP41 ASAP1 active dynein-2motorsCLASP1 ARF4:GDPTCTEX1D1 AKAP9 KIF3C