Cilium Assembly (Homo sapiens)

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3, 13, 34, 41, 47...25, 60, 68, 10235, 37, 804, 15, 69, 99, 116...88, 114, 1474, 69, 74, 125, 127...24, 29, 31, 68, 77...11, 45, 46, 68, 82...8, 90, 126144, 1582, 4, 23, 28, 50...9, 20, 30, 33, 47...1, 4, 5, 7, 22...2, 19, 35, 56, 80...15815, 99, 119, 127, 15452, 15816, 35, 37, 71, 80...4, 11, 23, 101, 13048, 85, 149, 153, 15652, 93, 1586, 43, 61, 79, 118...48, 74, 149, 1568, 90, 12615, 64, 99, 104, 119...42, 80, 81, 86, 106...11, 45, 62, 68, 82...2, 3, 35, 37, 70...39, 52, 59, 122, 132...25, 31, 53, 60, 68...39, 52, 59, 122, 132...4, 47, 10126, 158904, 12, 23, 28, 47...2, 23, 28, 50, 80...903, 38, 65, 74, 104...2, 35, 37, 80, 95...10321, 54, 61, 75, 89...2, 69, 98, 12715, 40, 55, 63, 73...1, 6, 22, 27, 32...39, 52, 59, 122, 132...7, 17, 18, 21, 51...49, 80, 13244, 96, 1546138, 61, 65, 7410, 14, 36, 38, 43...Golgi-associated vesicleciliumGolgi-associated vesicleendoplasmic reticulum lumenGolgi-associated vesicleGolgi lumencytosolCEP72 CDK5RAP2 SEPT2IQCB1 ASAP1 RP2 IFT172 PCNT DYNLL1 HSP90AA1 PLK4 ACTR1A exocystcomplex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteinsRHO IFT172 HAUS7 MAPRE1 IFT81 EXOC4 HSP90AA1 WDR60 AZI1 RHO RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteinsBBS1 TCTE3 ARL3:GTPIFT88 IFT80 IFT88 AZI1 OFD1 HSPB11 PKD1 PPP2R1A HAUS8 TTC30A KIFAP3 BBS4 CEP63 BBSome ciliary cargoTUBB4B TTC30B HAUS2 PRKAR2B HAUS3 IQCB1 IFT172 TTC8 CEP83 DYNLL1 IFT46 CLASP1 DYNC1I2 TUBA4A BBS2 CNGA2 TUBA1A CEP162 TUBB4A TTC30A B9D1 CNTRL NINL IFT43 retrograde IFTtrainsTCTN2 CCT4 SCLT1 AHI1 CDK1 IFT122 CNGA4 ACTR1A PAFAH1B1 CNTRL YWHAE TCTN1 TUBB4A CNGA4 RAB8A TNPO1 KIF3A ODF2 HAUS1 AKAP9 TCTEX1D2 DYNC2LI1 GDP KIFAP3 TTC26 GDP KIF17 CNGB1 CEP152 EXOC6 TUBG1 RAB11FIP3 GTP IQCB1 WDR34 CEP192 CEP57 TCTEX1D2 BBS/CCT complexKIF3A KIF17 dimer:TNPO1TUBA4A WDR34 DYNLRB1 IFT20 TCTEX1D2 CLUAP CENPJ PPP2R1A DYNLL1 PLK4 CNGA2 EXOC7 IQCB1 SCLT1 WDR60 YWHAG CCT5 IFT140 IFT122 IFT20 TCTEX1D1 basal bodyNINL PKD2 HAUS3 DYNC1H1 DYNLL1 RAB3IP YWHAG WDR60 RAB8A FBF1 GDP GTP CEP250 TCTEX1D2 SSNA1 DYNC1I2 NEDD1 TUBA4A CLASP1 MyrG2-NPHP3 CEP70 BBS4 RAB3IP TTC21B ARF4 FGFR1OP IFT BIFT74 CEP164 IFT88 ARL6:GTPIFT88 PCNT BBS7 DYNLRB2 CEP63 PKD1 ASAP1 dimerHAUS6 MyrG2-NPHP3 myristoylatedciliary cargoBBS9INPP5E TCTN1 KIF17 TRAF3IP1 KIF3A CEP164DCTN2 B9D1 PKD2 NPHP complexIFT46 HAUS4 GDPCEP162 PKD1 AKAP9 BBS1 HAUS4 CNTRL TRAF3IP1 PDE6D DYNLL1 IFT88 NDE1 PCNT HSP90AA1 ACTR1A GTPRAB8A:GTPHAUS7 NDE1 MAPRE1 DYNLRB2 DCTN1-2 CCP110 GTP SFI1 ARL3:GTP:UNC119B:myristoylated ciliary cargoPRKACA KIF24 CLUAP RHO ARL3:GDPCEP63 ODF2 KIF3B DYNC2H1 CCP110BBS9 AKAP9 IFT140 CEP70 MyrG2-NPHP3 LZTFL1 oligomerPLK1 CEP97 PRKACA DCTN2 RAB8A TCTEX1D2 CSNK1D CEP57 DYNLRB2 RAB3IP:RAB8A:GDPCENPJ IFT57 MARK4 KIF3A PRKACA NEDD1 IFT20 CETN2 TTBK2 OFD1 RAB11FIP3 IFT81 RABL5NINL NDE1 IQCB1 WDR19 YWHAG PKD2 CEP83 DCTN3 SSNA1 GTP SFI1 ARL6 RHO TUBB4A FBF1 KIF17 PRKAR2B CENPJ CKAP5 NPHP4 DYNLL2 CEP192 HAUS5 RAB3IP RAB11A PAFAH1B1 RABL5 PLK1 AZI1 IFT46 KIF17 SSNA1 CEP97 CEP290 NPHP1 CC2D2A UNC119B myristoylatedciliary proteinsCEP152 ARF4:GTP:VxPx-containing ciliary membrane proteinsIFT172 CEP70 CEP78 IFT27 HAUS6 IFT27 HAUS8 CEP135 OFD1 NPHP1 IFT81 ARL3 CEP78 RAB3IP:BBSomeCEP83 ODF2 NEK2 GTP KIF17 KIF24 TUBA1A CEP41 CEP97 HAUS6 IFT52 HAUS3 DCTN2 CEP70 CEP41 GTP MAPRE1 ARF4 IFT140 LZTFL1 ODF2 TCTN2 BBS2 TRIP11IFT20 DYNLL1 NPHP1 PAFAH1B1 CSNK1E CEP164 HAUS1 MAPRE1 MyrG2-CYS1 CENPJ TCTEX1D1 DYNC1H1 IFT57 HDAC6DYNC2H1 WDR35 DYNLRB1 UNC119B TTC26 KIF3C CEP290 PLK4 SFI1 BBS5 EXOC1 TTC21B ARL3 TUBA1A BBIP1 CCP110 HAUS1 NDE1 CEP41 GTP CEP250 HAUS7 PKD2 TTC26HAUS4 TTBK2 TUBB4B TCTE3 TUBB Golgi-derived vesicle IFT81 FGFR1OP CEP72 IFT172 TUBA4A YWHAE PCM1 ARF4 TRAF3IP1HSP90AA1 NEK2 TTC26 KIF24 PAFAH1B1 KIF17 NEK2 TCTN2 ARL13BHAUS7 DYNLL2 KIF24 CEP250 ALMS1 GTP TUBG1 BBSomeFGFR1OP BBS1 SFI1 SFI1 TUBB DYNLL2 CEP63 KIF3B CETN2 TTC30B IFT52 RAB11A CEP97 RP2:ARL3:GTP:UNC119B(active)RAB11FIP3 TCTN3 INPP5EGDP PKD2 BBIP1 TTC30B BBS9 CCP110 SDCCAG8 RP2 CEP70 mother centrioleUNC119B IFT74 ACTR1A TCTEX1D1 CNGA4 AZI1 DYNLL1 LZTFL1 CEP162 CETN2 ARF4 CEP76 IFT BTCTE3 HAUS8 NEDD1 CEP89TCTEX1D1 CEP57 DYNLRB1 ARL6:GTP:BBSome:ciliary cargoTRAF3IP1 CNGA4 CEP290 SSNA1 CNGA2 ODF2 ARL13B PKD2 PRKAR2B MAPRE1 TMEM216 CNGB1 MARK4 TTC8 FBF1 YWHAE IFT81 SCLT1 AKAP9 FBF1 IFT81 GBF1ALMS1 SCLT1 TTC8 CEP135 WDR60 HAUS8 TUBA1A MARK4 TNPO1 TTC30B DYNC2H1 basalbody:transitionzone proteinsAKAP9 KIF3A TCTE3 HAUS5 SFI1 HAUS6 ARL3 IFT57 IFT80 PLK1 DYNC2H1 TUBG1 OFD1 CNGA2 NEDD1 TTC26 IFT20 CSNK1E IFT52 SMO PCNT CDK5RAP2 CSNK1E ARL13B KIF3C YWHAE DCTN1-2 PAFAH1B1 BBS9 PRKACA DYNLRB2 EXOC1 TTC30A HAUS4 MAPRE1 CEP164 IFT172 UNC119B WDR19CDK1 IFT81GTP ACTR1A NINL DYNLRB2 CLASP1 SCLT1DCTN2 C2CD3 IFT20 CEP162 WDR35 DCTN2 ARF4 HAUS2 ALMS1 KIF3B TRAF3IP1 CNGA2 UNC119B IFT74 NEK2 SDCCAG8 CEP41 TUBG1 NDE1 HSPB11 CEP290 Golgi-derived vesicle PRKAR2B BBS1 BBS5 RAB3IP IQCB1 PKD1 IFT ACEP72 DYNC1I2 SDCCAG8 CCT8 GTP CoA-SHPKD2 ASAP1 HAUS6 SSTR3 PLK1 IFT74 KIFAP3 BBS5RHO TTC26 CDK1 PKD1 CEP192 CEP70 MAPRE1 CEP250 RAB11FIP3 DYNC1I2 PCNT BBS5 HAUS4 C2CD3 WDR35TUBA4A BBS5 DYNLRB1 SDCCAG8 PRKACA EXOC3 IFT43 CEP72 CEP135 KIF24 GDP CNGA4 CNGB1 B9D1 CETN2 CKAP5 ARL6:GTP:BBSome:ciliary cargoC2CD3CNGA2 CEP78 DYNC1I2 IFT43 DYNC2LI1 TTC8RP2:ARL3:GDP:UNC119BPDE6D AZI1 IFT80 WDR34 TTC30B IFT122 EXOC8 acetylated microtubule CNGA2 KIF3B PLK4 HSPB11 GTP CNGA2 ARL13B:INPP5EDYNC1H1 CEP164 HSPB11 AHI1 CNGA2 CEP135 CENPJ SFI1 DYNLL2 MKS1 IFT46 CC2D2A CEP192 CEP250 WDR19 FBF1GTP RAB11A TTC26 DCTN1-2 CEP152 B9D2 TTC30A KIFAP3 TUBG1 CSNK1D HAUS3 CSNK1E SMO TUBA1A CEP72 INPP5E HAUS8 IFT172 Centrosome:C2CD3:distal appendage proteinsSCLT1 TUBB4A BBS7 CEP152 CEP78 GTP retrograde IFTtrainsDYNLL1 WDR34 TUBG1 PKD1 PRKAR2B WDR60 basalbody:transitionzoneproteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicleUNC119B:myristoylated ciliary cargoDCTN3 YWHAG VxPx-containingciliary membraneproteinsOFD1 SDCCAG8 CEP83 PCM1 RABL5 TTC30A DYNC2H1 HSPB11 MyrG2-CYS1 RHO CNGA2 PLK4 TRAF3IP1 BBS10 NEDD1 active dynein-2motorsKIF24 CNGB1 WDR60 IFT74 FGFR1OP BBS4 EXOC2 GTP CSNK1E WDR19 PiRAB11FIP3 dimerDYNC2LI1 Ac-CoAanterograde IFTtrainsSSNA1 ARF4:GDPIFT52 YWHAE BBIP1BBIP1 TUBG1 TUBA4A TCTEX1D1 CNGB1 CEP135 acetylated microtubule TUBB PRKAR2B UNC119BRABL5 CEP57 TTBK2 IFT122 TNPO1UNC119B:myristoylated ciliary cargoDYNC1I2 CNGA4 HSPB11CEP135 DYNC2LI1 CDK1 MCHR1 MARK4 RAB11A IFT27 EXOC2 HAUS6 TUBB acetylated microtubule IFT43 TTC30A ARL13B:INPP5E:PDE6DTTC30A CEP63 ACTR1A acetylatedmicrotubuleCEP152 OFD1 CNTRL TCTE3 RAB8A:GDPPRKAR2B CKAP5 Centrosome:C2CD3:distal appendage proteins:TTBK2CEP72 WDR19 CEP41 RAB11A Golgi-derived vesicle CEP63 DCTN1-2 DCTN1-2 RAB8A GTP DYNC1H1 HSP90AA1 BBS2 PLK4 dynein-2TTC30B GDPHAUS8 NDE1 INPP5E PCM1 YWHAE ASAP1 PPP2R1A CEP70 CNGB1 SSTR3 IFT81 YWHAG CEP290 UNC119BTTC8 NDE1 YWHAG RP2HSP90AA1 UNC119B IFT20RAB8A TCTN1 BBS9 RAB11A CNGA4 PLK1 EXOC6 CEP78 ODF2 PRKACA EXOC8 IFT74 KIF3A CEP89 CKAP5 HSPB11 CEP152 CLUAP acetylated microtubule CEP290 DCTN1-2 IFT57 C2CD3 CLUAP TTBK2CEP83CEP76 CEP162 IFT27PLK1 CSNK1D AZI1 YWHAE CKAP5 PPP2R1A HAUS6 DYNC1H1 CEP72 MyrG2-CYS1 DCTN3 HAUS7 CDK5RAP2 WDR34 NEDD1 CSNK1D PKD1 NEK2 IFT80 PDE6DTMEM67 ALMS1 CCP110 B9D2 DYNLL1 CLASP1 DYNC2LI1 CDK1 NEK2 C2CD3 H2OHAUS8 IFT57 ARL3 CNGA4 NEK2 ACTR1A FBF1 NINL RP2 RAB11FIP3 RPGRIP1L FBF1 CEP97HAUS3 SMO GTPTUBG1 TUBB4A AZI1 PAFAH1B1 DYNLL1 SDCCAG8 CETN2 OFD1 IFT88 PPP2R1A CEP290 IQCB1 acetylated microtubule RABL5 BBS7EXOC7 CKAP5 ARL6 HAUS4 TUBA1A HAUS1 KIFAP3 VxPx-containingciliary membraneproteinsCEP164 UNC119B IFT80CEP78 IFT74 HAUS5 DYNLL1 Kinesin-2 motorsDYNC1H1 MyrG2-CYS1 TCTEX1D2 SDCCAG8 TTC21BMicrotubule protofilament INPP5E HAUS1 TCTE3 CEP89 CDK5RAP2 IFT80 TTC21B CKAP5 KIF24 HSP90AA1 TUBB4A CEP135 HAUS3 CEP250 CEP152 acetylated microtubule IFT88HAUS1 HAUS6 IFT122 SCLT1 DYNLRB2 DYNLRB1 RAB11A CEP41 PCM1 CEP76 GTP BBS2 DYNLL1 CSNK1E DYNC1I2 CEP83 PLK1 RAB8A IFT B*TUBA1A CSNK1D RAB8A DYNC1I2 IFT172HAUS5 WDR19 DYNLL1 DCTN3 TTBK2 KIF24 IFT27 ASAP1 PCM1 CSNK1E CETN2 RAB3IP HAUS5 DYNC2H1 CEP70 ALMS1 TRAF3IP1 HAUS2 EXOC3 KIF17 RAB3IP CNGB1 PCNT RAB11A IFT74CCT2 BBS7 KIF3B ARL3:GTP:UNC119BIFT52ARL6 TTBK2 RAB3IP:RAB11A:GTP:Golgi-derived vesicleCEP250 CEP290 WDR60 RAB11A:GTP:RAB11FIP3dimer:ASAP1dimer:ARF4:GTP:VxPx-containing ciliary membrane proteinsDYNC2LI1 CLASP1 BBS1CDK5RAP2 CEP63 CC2D2A MyrG2-NPHP3 BBS2CNTRL HAUS5 TTC8 HSP90AA1 RP2:ARL3:GTP:UNC119BPLK4 FGFR1OP RAB3IPHSPB11 BBS4TUBA4A CLUAP KIF17 dimer:TNPO1DYNLL2 PDE6DMyrG2-CYS1 B9D2 CEP76 CEP57 DYNLL1 KIF3C TUBB CEP83 IFT43 HAUS3 CEP72 KIF17 KIF3A active kinesin-2motorsCEP57 CNTRL KIF17 TTC21B PDE6D:INPP5ERHO TUBB4B IFT80 KIF17 dimerCEP76 DCTN3 PKD2 CEP76 RAB3IP CLASP1 TMEM216 MCHR1 PKD1 GTPARL3 CCP110 KIFAP3 CENPJ IFT20:TRIP11Kinesin-2 motorsWDR35 YWHAE PCM1 HAUS4 IFT27 DCTN2 RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteinsWDR34 HAUS1 ARL3 CNGB1 TMEM67 CNGB1 CEP89 CEP162 DYNLL2 KIF3C RAB3IPCEP57 HAUS2 PKD2 CEP135 TRIP11 BBS7 TUBB4A MyrG2-NPHP3 CEP152 CNGA4 ASAP1 RHO SSNA1 TMEM67 PKD1 BBS4 CLASP1 CETN2 TTC30B CDK1 TCP1 CENPJ NINL BBS5 KIF3C ALMS1 PRKACA TUBA4A BBS12 TTC26 GDP IQCB1 CSNK1D TUBB RAB11A:GTP:RAB11FIP3dimer:ASAP1dimer:VxPx-containing ciliary membrane proteinsRHO HAUS2 RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteinsC2CD3 NPHP4 IFT88 DYNLRB2 HAUS8 CEP63 PPP2R1A DCTN2 CLASP1 IFT46BBS2 IFT57 CEP78 GTP DCTN1-2 CEP97 KIF3B TUBB4B TUBB4B NEDD1 RHO PAFAH1B1 IFT140 TMEM216 ASAP1 CEP162 DYNLRB1 RAB11A CNTRL TTC30A CDK5RAP2 CEP89 SSTR3 ATATSDCCAG8 KIF3C PCNT FGFR1OP MKS1 BBS9 DYNC1H1 KIF3C TUBB4B IFT43KIF17 ODF2 WDR34 ALMS1 CDK5RAP2 OFD1 TCTN3 IFT140 centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4MKKS IFT43 TRAF3IP1 TUBA1A IFT52 RPGRIP1L NDE1 IFT52 CDK1 AKAP9 PRKAR2B SSNA1 TUBB PDE6D:INPP5ECSNK1D TTC30B MAPRE1 DCTN2 SFI1 CEP192 Tectonic-likecomplexIFT57 GTP DYNLRB1 DYNC1H1 MicrotubuleTUBB4A TCTE3 PLK4 TCTEX1D2 C2CD3 CEP78 CEP76 ACTR1A CEP57 BBIP1 PKD2 TTC21B IFT46 IFT57C2CD3 AZI1 EXOC4 acetylated microtubule protofilament CDK5RAP2