Signaling by MET (Homo sapiens)

From WikiPathways

Revision as of 11:25, 1 November 2018 by ReactomeTeam (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
1, 2, 4, 6-8, 11...17, 9717, 3554, 48, 8122, 36, 82, 83, 10110841894, 5632, 33, 40, 43, 53...70383, 4, 1094, 6, 62, 64, 718, 58, 72631081, 9610, 14, 49, 68, 104...29, 7822, 29, 75, 78, 826, 724, 233114, 7744, 706, 7221, 38, 46, 76, 9924, 38, 9838412011, 10710881110228, 34, 8810865, 94, 96, 10560, 92, 1144, 1099, 19, 57, 69, 85...3189, 941074, 23extracellular regionnucleoplasmcytosolNoteplasma membranerecycling endosome membraneITGA3(33-1051) MonoUb-K,p-Y1003,4Y-MET HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3KHGS HGF:p-Y,1349,Y1356-MET dimerPTPN11RAPGEF1GGA3GDPUBC(457-532) GRB2-1 HGF(495-728) p-5Y-GAB1 HGFAC(373-407) UBC(229-304) PTK2 MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET EPS15:HGS:STAMMET HGF(495-728) p-Y1234,Y1235,Y1349,Y1356-MET PIP3 activates AKTsignalingMET GRB2-1 HGF dimerHGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM)GTPHGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1)p-Y1234,Y1235,Y1349,Y1356-MET SOS1 HGF(32-494) CRKL CRK HGF(495-728) GRB2-1 MUC20GDPCBL HGF:p-4Y-METdimer:PTK2SH3GL3 p-Y1234,Y1235,Y1349,Y1356-MET Integrinalpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin)p-Y1234,Y1235,Y1349,Y1356-MET MyrG-p-Y419-SRC HGF(495-728) ATPp-Y1234,Y1235,Y1349,Y1356-MET HGF:p-4Y-METdimer:STAT3GGC-RAB4A HGF(495-728) HGF(495-728) STAM2 NRAS HGF(32-494) GAB1 SH3GL3 UBC(609-684) SHC1-2 p-Y1234,Y1235,Y1349,Y1356-MET ITGA2 p-5Y-GAB1 p-Y1234,Y1235,Y1349,Y1356-MET p-Y-CBL HGF(495-728) HGF(32-494) GRB2-1SH3GL2 PIK3R1 HGF(495-728) SH3KBP1 RAP1:GDPUBC(1-76) GRB2-1 ATPp-Y1349,Y1356-MET p-Y1234,Y1235,Y1349,Y1356-MET HGF:p-4Y-METdimer:RANBP9:SOS1HGF:p-Y1234,Y1235,Y1356-MET dimerGTP GRB2-1 UBA52(1-76) GRB2-1 p-Y705-STAT3HGF:p-4Y-METdimer:p-Y194,Y397,Y576,Y577-PTK2:MyrG-p-Y419-SRCTNS4:ITGB1ATPARF6 UBB(153-228) MET SH3GL1 HGF(32-494) RAC1 p-Y-CBL p-Y1234,Y1235,Y1349,Y1356-MET HGF:p-4Y-METdimer:TNS4:ITGB1UBB(77-152) PIK3R1 HGF(495-728) CRKL HRAS MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET EPS15 HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-MET dimer:p-Y-CBL)HGF(32-494) RAPGEF1 TNS3PiRAP1B PI(4,5)P2HGF(495-728) HGF(32-494) p-Y1234,Y1235,Y1349,Y1356-MET GRB2-1 SPINT1 HGF(32-494) GTPp-Y317-SHC1-2 HGF:p-4Y-METdimer:GAB1SOS1 H2OCRK SH3KBP1 SOS1HGF:p-4Y-METdimer:RANBP10UBC(153-228) GAB1 GRB2-1 HGF(495-728) ITGB1 SH3GL1 H2OUBB(77-152) HGF(32-494) GRB2-1 HGF(495-728) ARF6:GTPTNS4 UBC(77-152) HGF(495-728) HGF:p-4Y-METdimer:GAB1,HGF:p-4Y-MET dimer:GRB2:GAB1UBC(533-608) p-Y1234,Y1235,Y1349,Y1356-MET ATPp-Y317-SHC1-2 ADPHGF(32-494) p-Y1234,Y1235,Y1349,Y1356-MET STAM ATPHGF(32-494) SH3GL2 HPN heterodimerRANBP9RANBP9 UBA52(1-76) GRB2-1 HGF(32-494) SHC1-2HGF(495-728) PIK3CA:PIK3R1UBC(533-608) MET KRAS MyrG-p-Y419-SRC HGF(495-728) CIN85:endophilinH2Op-Y1234,Y1235,Y1349,Y1356-MET HGF:MET dimerGTP Fibronectin matrix TNS3 GGA3 UBC(381-456) HGF(32-494) HGF:p-4Y-METdimer:SHC1-2p-Y1234,Y1235,Y1349,Y1356-MET SH3GL1 ADPp-Y1234,Y1235,Y1349,Y1356-MET GRB2-1 UBC(229-304) HRAS CRKL RAC1 p-Y1234,Y1235,Y1349,Y1356-MET MUC20 HGF(495-728) HGF:p-4Y-METdimer:GRB2:CBL,(HGF:p-Y1003,4Y-MET dimer:CBL)HGF(495-728) p-Y1234,Y1235,Y1356-MET p21 RAS:GTPHGF(32-494) GRB2-1:SOS1HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7)p-Y705-STAT3 dimerHGF:p-4Y-METdimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL)HGF(495-728) GTP MonoUb-K,p-Y1003,4Y-MET GGC-RAB4B RPS27A(1-76) Laminins Ub-LRIG1 CRKL HGF(495-728) MonoUb-K,p-Y1003,4Y-MET HGF:p-4Y-METdimer:GRB2-1:SOS1HGF(32-494) TNS4 DOCK7 RAC1:GDPATPp-Y1234,Y1235,Y1349,Y1356-MET HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11HGF(495-728) HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1UbHGF(32-494) USP8HGF:p-4Y-METdimer:p-Y397-PTK2:MyrG-p-Y419-SRCPTPN2 ADPp-Y705-STAT3 SH3GL3 HGF(495-728) p-Y1234,Y1235,Y1349,Y1356-MET HGF(495-728) PIK3CA Ub-LRIG1 PTK2RANBP10 HGF:p-4Y-METdimer:TNS3HGF(495-728) METHGF(495-728) HGF(32-494) p-Y1234,Y1235,Y1349,Y1356-MET p-Y397-PTK2 GRB2-1 UBC(305-380) GTP HGF(32-494) MET:LRIG1HGF(495-728) ADPHGF(32-494) HGF(495-728) STAT3 HGF(495-728) SH3GL2 HGF(32-494) RAC1:GTPRAP1:GTPHGF(32-494) HGF(32-494) CBL:GRB2,CBLGDP p-Y1234,Y1235,Y1349,Y1356-MET GRB2-1 ATPCBL UBB(1-76) HGF dimer:METGGC-RAB4:GTPPI(3,4,5)P3RAP1A HGF:p-4Y-METdimer,(HGF:p-Y1003,4Y-METdimer)HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillinHGF:p-4Y-METdimer:p-Y397-PTK2GRB2-1 HGF(495-728) p-Y1234,Y1235,Y1349,Y1356-MET CRK, CRKLKRAS HGF(32-494) HGF(32-494) p-5Y-GAB1 RAF/MAP kinasecascadeRAP1B HGF:p-4Y-METdimer:p-Y317-SHC1-2:GRB2:SOS1HPN(163-417) SPINT1HGF(32-494) p-Y705-STAT3 dimerHGFAC dimerHGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTPGRB2-1 HGF(32-494) p-Y1234,Y1235,Y1349,Y1356-MET PTPN1,PTPN2ADPGRB2-1 p-Y1003,4Y-MET HGF(495-728) GAB1 p-5Y-GAB1 HGF(32-494) UBC(305-380) HGF(32-494) p-Y1234,Y1235,Y1349,Y1356-MET HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1p-5Y-GAB1 SH3KBP1 p-5Y-GAB1 SH3GL1 ATPHGFAC(408-655) HGF(495-728) ARF6 HGF(32-494) SH3GL3 p-Y705-STAT3 HGF(32-494) HGF(32-494) RPS27A(1-76) HGF(495-728) HGF(32-494) SPINT2 Ub-LRIG1 p-Y1234,Y1235,Y1349,Y1356-MET PIK3CA SH3GL2 HGF(495-728) LRIG1HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimerHGF(495-728) MET p-Y1234,Y1235,Y1349,Y1356-MET HGF(32-494) HGF:p-4Y-METdimer:p-Y317-SHC1-2GTP p-Y194,Y397,Y576,Y577-PTK2 MET:Ub-LRIG1HGF:p-4Y-METdimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRCHGS MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET p-Y1234,Y1235,Y1349,Y1356-MET pro-HGFCRK HGF(495-728) p-Y1234,Y1235,Y1349,Y1356-MET MyrG-p-Y419-SRCUBC(153-228) GTP STAM2 SOS1 HGF(495-728) MonoUb-K,p-Y1003,4Y-MET HGF(32-494) ADPHGF(495-728) HGF(495-728) unknown ubiquitinligaseEPS15 HGF(32-494) HGF(32-494) UBB(153-228) UBC(381-456) RANBP10GAB1HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKLPTPN11 p-Y397-PTK2 PTPN1 ITGB1 MyrG-p-Y419-SRC STAT3STAM GRB2-1 SOS1 UBC(609-684) SPINT1,2GRB2-1 p-5Y-GAB1 p-Y194,Y397-PTK2 p21 RAS:GDPDOCK7 HPN(1-162) ADPCRK UBC(1-76) NRAS ADPMonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET p-Y1234,Y1235,Y1349,Y1356-MET (DOCK7)UbITGB1 p-Y-CBL ATPHGF(32-494) SH3KBP1 HGF(32-494) GDP CRKL GRB2-1 Collagen fibres MET LRIG1 HGF(32-494) p-Y1003,4Y-MET ADPGTPp-Y-CBL UBC(77-152) UBB(1-76) GDPUBC(457-532) HGF:p-4Y METdimer:MUC20HGF(495-728) PTPRJRAP1A p-Y-CBL HGF:p-4Y-METdimer:GRB2-1:GAB1CRK p-Y1234,Y1235,Y1349,Y1356-MET GDP 41444, 231081024610760108601116, 18, 27, 30, 39...22410873, 10041316, 72