Oxidative stress response (Mus musculus)

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Immediate-earlygene inductionrepressionReactive Oxygen SpeciesTF activationActivationStress-regulated MAP kinaseRepression of ROS-producing systemsTF inhibitionAdaptive responseInduction ofantioxidant genesInhibition of oxidasesGclcCatTxn2Nfkb1Mapk10FosJunbNRF2B1Hmox1Ugt1a1Gstt2XdhMgst1Gpx3Cyp1a1Mt1Sod2GsrNfixMapk14Sp1Nqo1Sod3MaoaCybaTxnrd1Gpx1Sod1Txnrd2


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GenMAPP notes 
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks 
Adapted from rat by GenMAPP.org

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117038view14:11, 16 May 2021EweitzModified title
89965view18:18, 6 October 2016Mkutmonfix unconnected lines
69190view18:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67564view11:26, 26 June 2013DdiglesOntology Term : 'oxidative stress response pathways' added !
41381view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
33386view14:42, 30 November 2009MaintBotRemoved group label
33043view21:34, 7 October 2009MaintBotone more connector
33042view21:33, 7 October 2009MaintBotadded connectors
29168view12:04, 9 April 2009EveloAdded annotations for SOD1, NRF2 (should be checked) and UGT1a
29166view11:49, 9 April 2009EveloCosmetic
21550view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Oxidative Stress]] moved to [[Pathway:WP412]]: Moved to stable identifier
8320view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Oxidative Stress]] moved to [[Pathway:Mus musculus:Oxidative Stress]]: Renaming species
7778view16:17, 18 December 2007MaintBotfixed category names
7483view12:42, 4 November 2007MaintBotAdded categories to GPML
19532view22:19, 22 May 2007I.Reyesgpml file for [[Mouse:Oxidative_Stress]]
6484view22:19, 22 May 2007N.Reyesgpml file for [[Mouse:Oxidative_Stress]]

External references


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NameTypeDatabase referenceComment
CatGeneProduct12359 (Entrez Gene)
CybaGeneProduct13057 (Entrez Gene) Probe set ID: u18729
Cyp1a1GeneProduct13076 (Entrez Gene)
FosGeneProduct14281 (Entrez Gene)
GclcGeneProduct14629 (Entrez Gene)
Gpx1GeneProduct14775 (Entrez Gene)
Gpx3GeneProduct14778 (Entrez Gene)
GsrGeneProduct14782 (Entrez Gene)
Gstt2GeneProduct14872 (Entrez Gene)
Hmox1GeneProduct15368 (Entrez Gene)
JunbGeneProduct16477 (Entrez Gene)
MaoaGeneProduct17161 (Entrez Gene)
Mapk10GeneProduct26414 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mgst1GeneProduct56615 (Entrez Gene)
Mt1GeneProduct17748 (Entrez Gene)
NRF2B1GeneProduct14391 (Entrez Gene)
NfixGeneProduct18032 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
Nqo1GeneProduct18104 (Entrez Gene)
Sod1GeneProduct20655 (Entrez Gene)
Sod2GeneProduct20656 (Entrez Gene)
Sod3GeneProduct20657 (Entrez Gene)
Sp1GeneProduct20683 (Entrez Gene)
Txn2GeneProduct56551 (Entrez Gene)
Txnrd1GeneProduct50493 (Entrez Gene)
Txnrd2GeneProduct26462 (Entrez Gene)
Ugt1a1GeneProduct394436 (Entrez Gene)
XdhGeneProduct29289 (Entrez Gene)

Annotated Interactions

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