Chromatin organization (Homo sapiens)

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37, 9013, 4447, 8887, 98952710032974021, 35, 60, 68, 69, 72...3022967, 8487, 9811, 26, 751003261, 11313, 44321, 41, 7128, 3362247, 88365921, 68, 931821, 35, 60, 68, 69, 72...367, 34, 77, 1101002221, 68, 9373, 11139438218, 221071129, 19, 29, 44, 51...8948, 57, 76657, 8446, 99168, 56, 85, 913, 20, 24, 31, 58...9, 19, 29, 51, 70...10, 23, 64, 78, 101...2981211, 2617, 45, 49, 114134, 7455, 64, 108102673, 1052530365450, 98, 106, 11118, 228310048, 57, 765, 29, 42, 44, 51...8, 56, 9117, 45, 49, 52, 114nucleoplasmcytoplasmTBL1X MeR18-histone H3 AcK-HIST1H4 SUDS3 H2AFZ ARID1A ING5 PADI4,(PADI1,PADI2,PADI3, PADI6)Me3K-28-HIST1H3A Histone HIST1H2B Me2sR4-HIST2H2AA3 Me2K80-HIST1H3A SMYD3 HIST1H4H2AFX Histone H2B PRMT5:pT5-WDR77,PRMT7Me3K-10-HIST1H3A CoA-SHMeK37-HIST1H3A Me2K10-HIST1H3A Me2sR4-HIST2H2AC HIST1H2AD RBBP7 KAT2A,B complexesELP5 AcK-HIST3H2A SWI/SNFchromatinremodellingcomplex:PRMT5:pT5-WDR77PADI1 SMYD3 Me3K10-HIST1H3A WHSC1, WHSC1L1Me3K5-HIST2H3A SMYD2 KDM3B RBBP7:Replicativehistone H3HAT1 EHMT2 NFKB1(1-433) SWI/SNF chromatinremodelling complexHIST2H2AC MeK37-histone H3AcK6-HIST1H4 EZH2 CoA-SHSAP18 WDR77 AcK(5,15,19,24)-histone H3 KMT2C Me3K28-HIST1H3A AcK9,14,18-p-S10,T11-histone H3 ACTL6A PADI4 p-T69,T71-ATF2KDM5A KDM4A PADI6 CH2OKMT2B WDR5 AcK15-histone H3Me3K21-HIST1H4REST KDM7A Histone H2A Me2K10-histone H3SETD1B SUV420H1,SUV420H2,(SMYD3)Acetylated corehistone octamerSETD7 AdoHcyPADI3 NCOA2(869-1464):KAT6A(1-1118)KAT7 Me2sR4-HIST1H4 AcK(6,9,13,17)-HIST1H4 Me2sR4-HIST1H2AJ MeK-10-HIST1H3A WDR77CH2OPRMT5 AcK14,18,79-p-T11-histone H3 SETD1A JMJD6AdoHcyHIST1H4 Me2K28-HIST1H3A NSLAdoMetSMARCE1 PRC2 (EZH2)Core:AEBP2KDM2B TADA2B TADA2A MeR3-replicativehistone H3,MeR9-replicativehistone H3,MeR18-replicativehistone H3,Me27-replicatvehistone H3Ac-CoAKDM4A Protein-L-citrullineMe2aR3-histone H3 CHD4 CDK4 AdoMetCO2SUCCAAcK(5,15,19,24)-HIST1H3A AdoMetNCOR1 HDAC2 CARM1ASH1L KDM5B CCND1 AdoHcyAdoMetacetateSETDB1KAT6:ING5:MEAF6:BRPF1,(2,3)SMYD3 AdoMetAcK(9,14,18,79)-p(S10,T11)-histone H3AcK-histone H3, H4ATF7IP NH3AdoHcySETD1B O2SMARCB1 Ac-CoAAcK-Me3K28-HIST1H3A PRMT5 MeK310-RELA MeR27-histone H3 SUCCAH2AFB1 AcK14,18-p-S10-histone H3 KDM4A, KDM4B, KDM4C,KDM4D, MINADNMT3A CCND1:CDK4:PRMT5:WDR77SETD8AcK-histone HIST2H2A Histone H3 Cit3-replicativehistone H3,Cit9-replicativehistone H3,Cit18-replicativehistone H3,Cit27-replicativehistone H3WHSC1L1 RBBP7AcK-histone H2B AcK14,18,79-p-T11-histone H3 KMT2B SMARCA4 AdoMet2OGKANSL2 HIST1H3A CARM1, PRMT6DOT1LMeK10-histone H3SUV39H1 SETD2COPRS KDM1A,KDM1BAcK(6,13,16,21)-histone HIST1H2B KMT2D MTA1 MeK10-HIST2H3A Histone H2A Histone H3 TAF9 USP22 KDM2A AcK14,18,79-p-S10-histone H3 MeR18-histone H3,Histone H3WDR5 SUV39H2 CO2MSL3 CO2HMG20B Me2aR3-HIST1H3A Histone H3 2OGHDAC1/2 deacetylasecomplexesELP6 Me2sR9-HIST1H3A AdoHcyKANSL1 MeK5-HIST1H3A pT5-WDR77 MeR4-histone H2A,Histone H2AMeR27-histone H3,Histone H3Me2aR-RPS2ELP4 KANSL3 AdoMetHIST1H4CCND1:CDK4:PRMT5:pT5-WDR77:COPRSCH2OAdoHcyHIST1H4 MORF4L1 KDM4A AcK(6,13,16,21)-HIST2H2BF ARID4B PRMT5 CSRP2BP O2SETD3 MeR27-replicative histone H3 SAP130 CDK4 ACTB(1-375) SMARCD3 Me2sR4-HIST1H2AH PHF21A MeR30-histone H2A,Histone H2AHDAC3-containingcomplexHistone H3 AdoMetCH2ORBBP7 AcK-replicativehistone H2B, H4AdoHcyMeK10-histone H3AdoHcyEHMT1 CDK4 H2ONCOA2 (869-1464)Me2K37-histone H3Ac-CoAKMT2D YEATS2 HDAC3 ACTL6B O2CH2OWDR5 NFKB2(1-454) SUCCACO2ENY2 Me2aR30-histone H2A SMARCA4 AEBP2 AcK14,18-p-S10,T11-histone H3 KDM2A KDM6A PRMT6 O2Me2sR4-H2AFZ Histone H2A AdoMetAcK9-HIST1H4 SMARCA2 WDR5:Me2sR3-histoneH3Cit9-replicative histone H3 AcK14,18-p-T11-histone H3 AcK17-HIST1H4 SUCCAO2MECOM KAT5 ING4 AdoHcyPADI2 SMARCC2 Me2sR4-HIST1H4,MeR4-HIST1H4PHF8 Histone H2A, H2B,H3, H4AdoMetMeR4-HIST1H4 Me2sR9-histone H3Ac-CoAING5 PAX3 (1-319)PRMT5 KDM2A, KDM2B, KDM4AVPS72 SMARCD3 TRRAP KMT2A SMARCB1 SUCCAPRMT6 Me2K28-HIST2H3A NuA4Ack15-HIST2H3A PRMT5:pT5-WDR77WDR77 AdoHcyARID1B AdoHcyHIST1H3A Me2K10-HIST2H3A KDM6B KDM1A KDM5A-DSMARCA4 PRDM16, MECOMMeR3-histone H3,Histone H3MeR4-histone H2A O2ING3 PADI4 OGT AcK17-HIST1H4MEAF6 AcK-histone HIST1H2A MeR4-HIST1H4,HIST1H4KDM4C SETDB1 CCND1 Me2sR3-HIST2H3A AcK14,18-p-S10-histone H3 Me2aR27-histone H3,MeR27-histone H3AdoHcyMEAF6 ARID2 PADI6 CHD3 EPC1 SAP30 MeK37-HIST2H3A SETD1B SMARCD1 ARID1B O2H2OMe2sR3-HIST1H3A DNMT3APRMT5 CoA-SHMeK21-HIST1H4KDM8 Me2aR4-histone H2A,MeR4-histone H2ASMARCA4MCRS1 Me2sR3-HIST2H3A Me3K10-HIST2H3A Ac-CoAMeR4-HIST1H4 AcK5,12-HIST1H4AHIST1H4 Ack-Me3K-histone H3PRDM16 AdoMetMe2sR4-HIST1H4Me3K80-HIST1H3A Histone HIST2H2A Me2sR4-HIST1H4 H2AFJ Me2sR3-HIST2H3A AdoHcyMeR30-histone H2A SUCCA2OGPBRM1 CO2CH2OCO2KMT2E AcK14,18,79-p-S10,T11-histone H3 AcK-histone H2A,AcK-HIST1H4Histone H2B PHF16 SUCCAAdoMetPHF17 ELP3 WDR5 MeR12-histone H2A MeR12-histone H2A KAT6A (1-1118)Me2K5-HIST2H3A RBBP4 MeR27-histone H3 pT5-WDR77 CO2Me2sR3-HIST1H3A NCOA1 (868-1441) pT5-WDR77 MeK28-HIST1H3A PADI1 Me2sR4-H2AFX SUZ12 SMARCD2 KDM7A Me3R-histone H3AcK15-histone H3,AcK-HIST1H4O2H2AFV MBIP WHSC1L1 PADIs:Ca2+KDM5C WHSC1 PRDM9 ATP2OGTRRAP RBBP4 ASH2L AdoHcyAcK-histone H2A Me3K37-histone H3KAT2A CH2OATXN7 Me2R4-HIST1H4:DNMT3AMe3K37-HIST1H3A HIST3H2A AcK10-histone H3 NCOA1 (868-1441)YEATS4 AdoMetAcK14,18-p-S10,T11-histone H3 Me2K28-histone H3AdoMetAdoHcyHAT1:RBBP7AcK9-HIST1H4 BRWD1:AcK(9,14,18,79)-p(S10,T11)-histone H3AdoMetMeR4-histone H2A O2AdoMetCoA-SHMe2K37-HIST2H3A AcK9-HIST1H4 CH2OMeR30-histone H2A EED AdoHcyMRGBP PHF15 BRD1 PRMT1 MSL1 HIST2H3A KDM2B AdoHcyAdoHcyMe2K5-histone H3Me2K37-HIST1H3A MeR9-HIST1H3A BRMS1 DPY30 Ca2+ Me3R-histone H3 Me2sR4-HIST1H2AA AcK10-histone H3,AcK-HIST1H4Me2sR9-HIST2H3A WHSC1L1 AdoMetSUCCAHDAC10Me2aR4-histone H2A 2OGPBRM1 AdoMet2OGAdoMetRUVBL1 TADA3 AcK9,14,18,79-p-S10,T11-histone H3 2OGAcK9,14-p-S10-histone H3 KMT2B Histone H3HIST1H2AB Me2sR3-HIST1H3A MeK5-HIST2H3A ARID4A HIST2H3A HDAC1 Ack15-HIST1H3A BRWD1:SMARCA4AcK6-histone H2A AdoHcyKDM6C ARID1A MTA2 EP300O2WDR5 RELA Me3K37-HIST2H3A Me3K-histone H3AdoHcyMINA Me2K80-HIST2H3A PRMT3BRPF1 Me3K28-HIST2H3A AdoMetEP400 Histone H2A ATXN7L3 ASH2L CCND1 Cit18-replicative histone H3 Histone H2A DPY30 Me2aR30-histone H2A,MeR30-histone H2ACO2ARID5B CO2MeR3-HIST1H3A Me2aR12-histone H2A AdoHcyAdoHcyMe2K21-HIST1H4TAF10 MeR9-histone H3RBBP7 KAT8 AdoMetMe3K5-HIST1H3A Histone H2A, HIST1H4NH3Me2sR4-histone H2AMe2aR12-histone H2A,MeR12-histone H2ASETD1A KAT8 TAF12 AcK15-histone H3 DR1 Me3K10-histone H3NFKB1(1-433) Cit3-replicative histone H3 SUV420H1 Histone H3AdoHcyATF7IP:SETDB1CCDC101 PRMT1H2OMe3K5-histone H3KMT2A HIST3H2BB IKBKAP AdoHcyCH2OPRMT1,PRMT6SMARCE1 SUCCASMARCC1 KDM5D AdoHcyKDM3A AcK(6,13,16,21)-HIST3H2BB Histone H3, H4SETD6SETD1B AdoMetHIST1H4 CH2OTAF6L TBL1XR1 AdoMetKMT2C MORF4L2 AcK14,18,79-p-S10-histone H3 Me3K28-histone H3AcK15-replicative histone H3 Me2aR-histone H3 2OGHDAC8AcK14,18,79-p-S10,T11-histone H3 SUCCAKMT2D WDR5 Histone H3 O2AdoMetCO2HIST1H4 AdoHcyMe2aR18-histone H3,MeR18-histone H3SUV39H1, SUV39H2,SETDB1, SETDB2HIST1H2AJ AcK-HIST1H4 Me2K80-histone H3KAT2B NSD1 WHSC1, NSD1, SMYD2,ASH1LCH2OAdoHcyGPS2 2OGAdoHcyNFkB Complex withMeK310-RELASUCCARBBP7 MTA3 KAT7:ING4,5dimers:MEAF6:PHF17,(15,16)NCOA1(868-1441):PAX3(1-319)SUCCAARID2 Elongator complexO2RBBP5 AcK17-HIST1H4 Histone H2B O2MeK80-HIST2H3A SMARCD1 MeK28-HIST2H3A KAT6A TADA1 MeR3-HIST2H3A Me2sR4-H2AFB1 DMAP1 HIST2H3A RBBP5 MeK28-histone H3ELP2 AcK9-HIST1H4 PHF20 AcK15-histone H3 Me3R-histone H3 MeK80-HIST1H3A Ack-Me3K5-HIST1H3A SUPT7L Core MLL complex,SMYD3, PRDM9SETDB2 CO2KAT6B MeR4-HIST1H4PHF2 SMARCC1 SUPT3H AcK(6,13,16,21)- histone H2B SAP30L SUPT20H Ins(1,4,5,6)P4 MSLGATAD2B PHF8CH2OHIST1H2AC AcK-HIST1H4 AdoHcyCO2KDM6A,KDM6B,KDM6C,KDM7ACit27-replicative histone H3 AcK6-HIST1H4 O2Histone HIST1H2A Me2K5-HIST1H3A KMT2C Me2sR3-histone H3CoA-SHAdoMetDPY30 SETD3 AdoMetHIST2H2BF GATAD2A MeR18-histone H3 KDM1A CO2KDM4B HIST1H4 NCOA2 (869-1464) Core histone octamerPRMT5 KDM4D AcK9,14-p-S10-histone H3 AcK9,14,18,79-p-S10,T11-histone H3 SETD3, SETD7,WHSC1L1, Core MLLcomplexAdoMetMe2aR3-histone H3,MeR3-histone H3AcK(6,13,16,21)-HIST2H2BE HIST1H3A Protein-L-arginineKMT2E SUCCANFKB2(1-454) WHSC1L1, Core MLLcomplex, SMYD3,SETD3BRD8 SMARCA2 CREBBPCO2CLOCKCH2OAcK-Me3K10-HIST1H3A COPRSSUV420H2 RPS2Me2aR4-HIST1H4PRMT5CARM1 HIST2H2AA3 AdoMetAcK14,18-p-T11-histone H3 MeK5-histone H3Me2aR18-histone H3 AcK13-replicative histone H2B HIST1H4 HIST2H2BE RUVBL2 KDM1B HIST1H3A MeK80-histone H32OGSUCCA2OGSETD1A HIST2H3A ZZZ3 TAF5L Me3K5-HIST1H3A AdoHcyMe2sR4-HIST1H2AD RBBP5 SMARCC2 ADP2OGBRWD12OGMe2aR3-HIST2H3A Me3K80-HIST2H3A Histone H3 PAX3 (1-319) SMARCD2 pT5-WDR77 MSL2 PADI2 AcK9,14,18-p-S10,T11-histone H3 PRMT7 MBD3 JMJD6ACTL6B PRMT6MEAF6 Me3R-histone H3 JAK2 V617F2OGMeR9-HIST2H3A PADI3 CH2OMeK10-HIST1H3A BRWD1 AcK-histone H2B, H3,H4AdoMetMe2sR4-HIST1H2AB ACTL6A Histone H2AMeR9-histone H3 NFkB ComplexWDR5MeR18-histone H3 BRPF3 AdoMetPRMT5 EHMT1:EHMT2AcK-HIST1H4CCND1:CDK4:PRMT5:pT5-WDR77p-Y297,304,307-PRMT5AcK-HIST1H4 HCFC1 AcK-histone H2A,H2B, H3, H4RCOR1 Histone H2B, H3, H4KMT2A ATF7IPHistone H2B, H4Me3K80-histone H3AcK(5,15,19,24)-HIST2H3A CH2OMeK10-HIST2H3A NCOR2 PRMT5:WDR77MeR12-histone H2A,Histone H2AACTL6A KDM2A, KDM2B, KDM4A,KDM8BRWD1 pT5-WDR77 KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8ASH2L Me2sR4-HIST1H2AC KMT2E KAT6A (1-1118) WHSC1 Me2R3-histone H31036181431036192613814, 6610310361251036161811036161103103818161103103616110361611036161611561