Chromatin organization (Homo sapiens)

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16, 996526, 375922, 93301450, 1021711283145979, 837, 43, 45, 53, 76713015, 1828, 33, 3414, 10366, 8810348, 1151, 506535, 61, 6714409420, 31, 52, 70, 81...28, 3415, 19, 38, 78, 87...85, 113, 114541047, 64, 684614, 103497, 43, 45, 531, 8, 69, 832111226, 3712, 95639, 41, 75, 8860112651821976, 24, 10715, 1884, 928246, 24, 1073, 29, 56, 57, 64...392721257379, 838911135, 61, 672, 6, 11, 24, 36...2115, 19, 23, 32, 38...5, 51, 9666, 882, 6, 11, 24, 36...10019, 38, 55, 78, 87...85, 109, 113, 114nucleoplasmcytoplasmWHSC1L1 JAK2 V617FBRPF1 AdoHcyDPY30 RUVBL2 AdoMetMe3K80-histone H3RBBP5 Histone H2B SAP30 O2KANSL1 NCOA2 (869-1464)HDAC2 MORF4L1 Me2K5-HIST1H3A Me3K5-HIST1H3A MeR4-HIST1H4,HIST1H4SETD1B AdoHcyAdoMetMBIP Me2sR4-H2AFZ acetateASH1L AcK(5,15,19,24)-histone H3 AcK-histone H2A NuA4MeR30-histone H2A MSLAdoHcyPAX3 (1-319) Core MLL complex,SMYD3, PRDM9AdoHcypT5-WDR77 Me3K28-HIST1H3A MRGBP AdoMetMeR4-HIST1H4 SETD3 MTA2 Cit9-replicative histone H3 GATAD2B Me2sR4-HIST1H2AH AdoMetMECOM MeR18-histone H3 AcK-HIST1H4 PADI6 KDM2B Me2sR9-HIST1H3A MeK10-HIST1H3A AcK9,14,18-p-S10,T11-histone H3 SUCCACDK4 Histone H3 HMG20B SUV39H1, SUV39H2,SETDB1, SETDB2PADI3 Me3K-28-HIST1H3A NFKB2(1-454) AdoHcyCH2OZZZ3 AdoHcySMARCD2 Cit18-replicative histone H3 REST SUCCACCND1:CDK4:PRMT5:WDR77MeR12-histone H2A AdoMetAdoHcyMeK5-histone H3DNMT3AMe2K5-histone H3CH2OAdoMetKAT6B WHSC1L1, Core MLLcomplex, SMYD3,SETD3KMT2C MeK28-HIST1H3A KDM4A SUZ12 SETD2PADI1 CCND1 MeR3-histone H3,Histone H3Histone H3 Me2sR4-HIST2H2AA3 AdoHcyCO2MeR18-histone H3 SUCCAPRDM16 PADI6 Histone H2B EHMT1 WDR5 AcK14,18-p-S10-histone H3 MeK10-HIST2H3A PRC2 (EZH2)Core:AEBP2SMARCE1 AcK-histone H2A,H2B, H3, H4BRWD1:AcK(9,14,18,79)-p(S10,T11)-histone H3KMT2A AdoMetCH2OPRMT5 MeR9-histone H3AcK15-histone H3CHD3 Ins(1,4,5,6)P4 ASH2L SETD1B HDAC10MeK28-histone H3Me3R-histone H3 MeR3-HIST1H3A ELP5 PHF20 PRMT5 RPS2AcK17-HIST1H4 CO2AdoHcyNCOA1(868-1441):PAX3(1-319)PADI1 CO2AdoMetAdoHcyAck-Me3K5-HIST1H3A HIST1H4 MeK37-histone H3MeR27-replicative histone H3 AcK6-HIST1H4 PRMT5 KDM1A MEAF6 HIST2H2AA3 TAF9 AdoMetMe2sR4-HIST1H4 KDM7A HIST1H3A O2SMARCA4COPRSKDM7A MSL3 Histone H2AMeK21-HIST1H4BRD1 CH2ORBBP7 KMT2D SMARCC2 YEATS2 MeR27-histone H3 SUV420H1 BRWD1PHF2 H2AFZ AcK9-HIST1H4 CoA-SHMe2aR18-histone H3,MeR18-histone H3TBL1XR1 HIST1H4 HCFC1 Me2sR4-HIST1H2AB PRMT1,PRMT6CARM1KDM6A,KDM6B,KDM6C,KDM7AAdoMetMe3R-histone H3 EPC1 AcK-Me3K28-HIST1H3A ACTL6A MINA Me2aR4-HIST1H4ARID2 MeR18-histone H3 PRMT3KDM1A MeK10-histone H3ATF7IP SUV420H1,SUV420H2,(SMYD3)PRMT5:WDR77KDM6A Me2aR-histone H3 AdoHcyAdoHcyCit3-replicative histone H3 YEATS4 AdoHcyNFkB Complex withMeK310-RELAING4 WDR5 AEBP2 Me3K5-HIST1H3A ACTB(1-375) NH3PRMT5:pT5-WDR77,PRMT7HIST1H3A Me3R-histone H3HIST1H4AcK9-HIST1H4 SUCCAMeK80-HIST1H3A HIST2H3A NFKB2(1-454) PHF8SUCCAPBRM1 KDM8 ACTL6B ELP3 HIST2H3A CH2OH2AFB1 MTA1 Me2K80-HIST1H3A RBBP7 Ack15-HIST1H3A WHSC1 PHF15 Me2K28-histone H3ING3 AdoHcyASH2L CO2Me2K37-histone H3KMT2B SMYD2 SMARCB1 Me3K10-HIST1H3A Histone H2A HAT1 AdoHcyHistone H3 WHSC1, NSD1, SMYD2,ASH1LHistone H2A, H2B,H3, H4Me2R3-histone H3NCOR2 2OGTRRAP pT5-WDR77 Me2sR3-HIST1H3A O2MeR30-histone H2A CoA-SHSETD3, SETD7,WHSC1L1, Core MLLcomplexHDAC3-containingcomplexSETD1A Histone H2A, HIST1H4Me2K10-HIST1H3A TAF12 Me2sR3-HIST2H3A Histone H3 MCRS1 PRMT6 AcK-histone H2B, H3,H4Me2K21-HIST1H4PHF21A CH2OAdoMetMe2K5-HIST2H3A AcK(6,9,13,17)-HIST1H4 Protein-L-arginineMe2sR4-H2AFB1 SAP18 ARID1B KDM5A HIST2H3A Histone H3 Me3K-10-HIST1H3A KAT2B SMARCE1 Histone HIST1H2A WDR5 AcK9-HIST1H4 EED SETDB1 MSL2 O2Ac-CoACCND1:CDK4:PRMT5:pT5-WDR77CCND1 H2OHistone H3Me2aR3-histone H3 WDR5 AdoHcyAcK14,18,79-p-S10-histone H3 AdoMet2OGKAT6:ING5:MEAF6:BRPF1,(2,3)JMJD6AdoMetKMT2C KDM3A PRDM16, MECOMMeK10-HIST2H3A KMT2A SUCCABRMS1 2OGMTA3 HIST1H2AB 2OGRELA ACTL6A TAF10 MeK-10-HIST1H3A Cit3-replicativehistone H3,Cit9-replicativehistone H3,Cit18-replicativehistone H3,Cit27-replicativehistone H3SMARCD2 ACTL6A AcK(5,15,19,24)-HIST1H3A SETD7 Elongator complexMe2aR3-histone H3,MeR3-histone H3AcK(6,13,16,21)-HIST3H2BB AcK10-histone H3 SETD1B AcK9,14,18,79-p-S10,T11-histone H3 TBL1X Me2aR12-histone H2A,MeR12-histone H2AKMT2B EZH2 PRMT5 H2AFV HDAC8AcK-histone H2A,AcK-HIST1H4BRWD1 EP300CARM1 CH2ODNMT3A Ac-CoACore histone octamerKDM6B HIST1H42OGHIST1H4 Me2sR4-histone H2AAdoMetRBBP4 ELP6 Me2sR3-HIST2H3A Me2aR-RPS2AcK15-histone H3 Me2K37-HIST1H3A TAF5L 2OGSMYD3 NSD1 AcK14,18-p-S10,T11-histone H3 DOT1LAdoHcyHIST1H3A WDR77HIST1H4 HDAC1/2 deacetylasecomplexesCO2RUVBL1 HIST1H4 AcK14,18-p-S10-histone H3 NSLHistone H2A 2OGSUV420H2 MEAF6 H2OAcK9,14-p-S10-histone H3 KMT2A BRWD1:SMARCA4PRDM9 MeK5-HIST1H3A KMT2D OGT AdoHcyCa2+ Me3K80-HIST2H3A KAT6A MBD3 SMARCD1 Me3K28-histone H3Me3K-histone H3KAT5 HIST2H2AC Histone H2B KAT8 MeR4-HIST1H4 IKBKAP HIST2H2BF CoA-SHSMARCA2 AdoMetMe3K80-HIST1H3A AdoHcyACTL6B CH2OMe2sR4-H2AFX MeR4-histone H2A KDM1B CH2OCoA-SHProtein-L-citrullineSUCCAMEAF6 Ac-CoAAcK-histone HIST2H2A KMT2C CO2AcK14,18,79-p-T11-histone H3 AcK9,14,18,79-p-S10,T11-histone H3 KAT2A Me2sR4-HIST1H4 COPRS PRMT6 Me3K10-HIST2H3A WDR5 O2DR1 AcK13-replicative histone H2B USP22 AcK14,18-p-T11-histone H3 KDM5A-DCHD4 RBBP7:Replicativehistone H3Me2aR3-HIST1H3A Me3K28-HIST2H3A RBBP4 HIST1H4 AcK10-histone H3,AcK-HIST1H4DPY30 CDK4 RBBP7 SMYD3 SETD3 SUPT20H PADI4 Me3R-histone H3 MeR4-histone H2A,Histone H2APADI2 ARID1B Me2sR4-HIST2H2AC AcK(6,13,16,21)-histone HIST1H2B AcK-HIST1H4 AcK-histone H3, H4AcK9-HIST1H4 KDM1A,KDM1BMe2aR12-histone H2A AdoHcySETDB1ARID4B VPS72 AcK14,18,79-p-S10-histone H3 CH2OSUPT7L MeK5-HIST2H3A SUCCAAdoMetHIST2H2BE AdoMetCLOCKSMARCA2 AdoHcyGPS2 NCOA2 (869-1464) ENY2 AdoHcyHIST1H2AC KMT2E SETDB2 SETD8CCND1:CDK4:PRMT5:pT5-WDR77:COPRSHistone H2B, H3, H4Me3K10-histone H3SETD1A CO2JMJD6TADA1 AcK9,14-p-S10-histone H3 EHMT2 ING5 SAP130 AdoMetKANSL2 SMARCC2 PRMT6TADA2A AcK15-histone H3 Me2sR3-histone H3AdoMetMe3K5-HIST2H3A SUCCASUCCAMeR18-histone H3,Histone H3WDR5MeK10-histone H3MeR4-HIST1H4AcK14,18-p-T11-histone H3 CO2CO2PRMT5ELP2 HAT1:RBBP7CH2OPHF8 SUCCAMe2aR4-histone H2A,MeR4-histone H2A2OGKDM2B WDR5:Me2sR3-histoneH3RBBP7AdoHcyKDM4D Me2K37-HIST2H3A MeR3-HIST2H3A AdoMetSWI/SNF chromatinremodelling complexO2SMARCD1 Histone H2B, H4Me2aR3-HIST2H3A SMARCD3 ATXN7L3 Me2K28-HIST2H3A AcK14,18,79-p-T11-histone H3 CDK4 pT5-WDR77 H2OH2AFX KDM4A, KDM4B, KDM4C,KDM4D, MINAKDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8H2AFJ Me2K80-histone H3SUCCAAcK14,18,79-p-S10,T11-histone H3 AdoMetPHF16 O2PRMT7 Me3K37-HIST1H3A AdoHcyATPMe3K37-HIST2H3A DMAP1 Cit27-replicative histone H3 NH3Histone H2A MeR12-histone H2A Me2sR4-HIST1H2AJ GATAD2A MeK37-HIST2H3A CoA-SHHIST3H2BB AdoHcyAcK17-HIST1H4 ARID1A Histone H2A Me2sR3-HIST2H3A SUV39H1 Me2aR27-histone H3,MeR27-histone H3AcK9,14,18-p-S10,T11-histone H3 HIST2H3A KMT2E O2MeK37-HIST1H3A AcK-replicativehistone H2B, H4AcK-histone HIST1H2A O2SMARCD3 NCOA1 (868-1441)AcK6-HIST1H4 AdoMetKDM2A, KDM2B, KDM4A,KDM8Histone HIST1H2B MeR9-HIST1H3A Me3K5-histone H3AcK(5,15,19,24)-HIST2H3A Me2aR30-histone H2A,MeR30-histone H2AAcK6-histone H2A BRPF3 EHMT1:EHMT2SUCCAARID2 AdoMet2OGO2WHSC1L1 KDM4A 2OGPAX3 (1-319)2OGMeR9-histone H3 EP400 AcK14,18,79-p-S10,T11-histone H3 Me3K37-histone H3Me2K10-HIST2H3A pT5-WDR77 Histone H3, H4ARID1A O2KAT7 ASH2L DPY30 Me2aR30-histone H2A CH2OHDAC1 PADI4 HDAC3 AdoMetKAT2A,B complexes2OGPHF17 Histone H3 HIST1H3A AdoMetp-T69,T71-ATF2Acetylated corehistone octamerMe2sR3-HIST1H3A MeR4-histone H2A Me2sR4-HIST1H4,MeR4-HIST1H4RCOR1 AcK-HIST1H4 ARID5B AdoHcyAcK(6,13,16,21)- histone H2B Me2sR9-HIST2H3A PRMT1 CO2SMYD3 CREBBPCO2Me2K10-histone H3AcK-histone H2B ATF7IPAcK-HIST3H2A p-Y297,304,307-PRMT52OGMe2sR9-histone H3ADPTAF6L CCND1 AdoHcyAcK15-replicative histone H3 KMT2E pT5-WDR77 AdoHcyAcK-Me3K10-HIST1H3A AcK5,12-HIST1H4AWHSC1L1 HIST1H2AJ Me2sR4-HIST1H2AC SMARCC1 Me2sR4-HIST1H2AD AdoMetPRMT12OGBRD8 PADIs:Ca2+WDR77 PADI3 SUDS3 Histone H3MeR9-HIST2H3A Me2aR4-histone H2A Me2sR4-HIST1H2AA TADA2B KDM5D O2MSL1 WDR5 AcK17-HIST1H4HIST1H2AD AcK-HIST1H4 MeK28-HIST2H3A SMARCB1 ATF7IP:SETDB1CO2HIST3H2A Ac-CoAKDM5C TADA3 SMARCA4 MeR12-histone H2A,Histone H2APRMT5:pT5-WDR77ELP4 ATXN7 NCOA2(869-1464):KAT6A(1-1118)SETD1A MeK310-RELA Me2aR18-histone H3 NFkB ComplexKDM5B Me2sR4-HIST1H4KAT6A (1-1118) KMT2B KDM3B CO2Histone HIST2H2A PRMT5 SAP30L AcK(6,13,16,21)-HIST2H2BE HIST1H4 ARID4A TRRAP O2CARM1, PRMT6MeK80-histone H3KDM4A CO2KAT7:ING4,5dimers:MEAF6:PHF17,(15,16)KDM2A, KDM2B, KDM4ASETD6SMARCA4 MeR30-histone H2A,Histone H2ANFKB1(1-433) NFKB1(1-433) WHSC1, WHSC1L1CH2OAcK(9,14,18,79)-p(S10,T11)-histone H3PADI4,(PADI1,PADI2,PADI3, PADI6)PADI2 WHSC1 KDM4B CSRP2BP KMT2D Me2R4-HIST1H4:DNMT3AO2SUCCAAdoMetKAT8 CH2OAdoHcyNCOA1 (868-1441) SMARCC1 MeR27-histone H3,Histone H3AdoMetING5 AcK14,18-p-S10,T11-histone H3 KDM6C WDR77 MeR27-histone H3 CH2OKDM2A PRMT5 Ack15-HIST2H3A KDM4C AdoMetKDM2A RBBP5 AcK-HIST1H4BRWD1 RBBP7 AdoHcyAc-CoAPBRM1 Me2K80-HIST2H3A SUV39H2 SWI/SNFchromatinremodellingcomplex:PRMT5:pT5-WDR77Ack-Me3K-histone H3CCDC101 Histone H2A MORF4L2 PRMT5 Me3K21-HIST1H4Me2K28-HIST1H3A RBBP5 KANSL3 MeK80-HIST2H3A MeR3-replicativehistone H3,MeR9-replicativehistone H3,MeR18-replicativehistone H3,Me27-replicatvehistone H3SUPT3H AcK(6,13,16,21)-HIST2H2BF KAT6A (1-1118)AdoMetAcK15-histone H3,AcK-HIST1H4NCOR1 SMARCA4 Me2sR3-HIST1H3A SETD1B 62928092921380809277928092809280801346809292131380808044, 1109280929292495892929292