RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (Homo sapiens)

From WikiPathways

Revision as of 11:40, 1 November 2018 by ReactomeTeam (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
3, 9, 12, 13, 20...3113, 31313113, 31913, 313113, 313113, 313, 3313, 3113, 31313, 3313, 3131319plasma membranecytosolnucleoplasmIFNG gene FOXP3 GeneTNFRSF18 gene RUNX1:CBFB:FOXP3geneRUNX1:CBFBCBFB RUNX1 RUNX1 RUNX1:CBFB:FOXP3:IFNG geneRUNX1 FOXP3RUNX1:CBFB:TNFRSF18geneRUNX1:CBFB:FOXP3:IL2RA geneFOXP3 CTLA4 geneTranscriptionalregulation by RUNX1RUNX1:CBFB:IL2RAgeneCBFB TNFRSF18 gene RUNX1:CBFB:FOXP3:CTLA4 geneCBFB TNFRSF18 geneCTLA4 gene IFNG geneCBFB FOXP3 Gene RUNX1 IL2 geneCBFB CR1 geneRUNX1:CBFB:CR1 geneNFATC2RUNX1:CBFB:FOXP3:NFATC2:IL2 geneRUNX1 RUNX1:CBFB:FOXP3:TNFRSF18 geneFOXP3 IL2RAIL2 gene CBFB RUNX1 CBFB RUNX1 IL2RA gene CBFB CTLA4 gene RUNX1 IL2NFATC2 CBFB CBFB RUNX1 FOXP3 RUNX1 FOXP3 CR1 gene CTLA4FOXP3 FOXP3 RUNX1:CBFB:CTLA4geneIL2RA geneRUNX1:CBFB:IFNG geneRUNX1:CBFB:FOXP3RUNX1 CBFB RUNX1:CBFB:NFATC2:IL2 geneCBFB RUNX1 TNFRSF18NFATC2 IL2RA gene RUNX1 RUNX1 CBFB IL2 gene CR1CBFB IFNGIFNG gene 3131313, 3331311, 2, 4-8, 10...313131213193131


Description

The complex of CBFB and RUNX1 (AML1) controls transcription of the FOXP3 gene. FOXP3 is a transcription factor that acts as a key regulator of development and function of regulatory T lymphocytes (Tregs). Tregs are CD25+CD4+ T lymphocytes involved in suppression of aberrant immune responses seen in autoimmune diseases and allergies. FOXP3 can bind to RUNX1 and control transcriptional activity of the RUNX1:CBFB complex. RUNX1 stimulates transcription of IL2 and IFNG1 (IFN-gamma), and the expression of these two genes is repressed upon binding of FOXP3 to RUNX1. The complex of FOXP3 and RUNX1, on the other hand, stimulates transcription of cell surface markers of Tregs, such as CD25, CTLA-4 and GITR. In the absence of FOXP3, RUNX1 represses transcription of these genes (Shevach 2000, Maloy and Powrie 2001, Sakaguchi 2004, Ono et al. 2007, Kitoh et al. 2009).
The RUNX1:CBFB complex directly stimulates transcription of the CR1 gene, encoding Complement receptor type 1 (CD35) (Kim et al. 1999, Rho et al. 2002). Expression of CR1 on the surface of activated T cells contributes to generation of Tregs (Torok et al. 2015). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 8877330
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: Orlic-Milacic, Marija

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Zhang L, Lukasik SM, Speck NA, Bushweller JH.; ''Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.''; PubMed
  2. Chen AI, de Nooij JC, Jessell TM.; ''Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord.''; PubMed
  3. Rho JK, Kim JH, Yu J, Choe SY.; ''Correlation between cellular localization of TEL/AML1 fusion protein and repression of AML1-mediated transactivation of CR1 gene.''; PubMed
  4. Mangan JK, Speck NA.; ''RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making.''; PubMed
  5. Keita M, Bachvarova M, Morin C, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Trinh XB, Bachvarov D.; ''The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion.''; PubMed
  6. Cai X, Gao L, Teng L, Ge J, Oo ZM, Kumar AR, Gilliland DG, Mason PJ, Tan K, Speck NA.; ''Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.''; PubMed
  7. Wong WF, Kohu K, Chiba T, Sato T, Satake M.; ''Interplay of transcription factors in T-cell differentiation and function: the role of Runx.''; PubMed
  8. Bäckström S, Wolf-Watz M, Grundström C, Härd T, Grundström T, Sauer UH.; ''The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.''; PubMed
  9. Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, Kitabayashi I, Tsukada T, Nomura T, Miyachi Y, Taniuchi I, Sakaguchi S.; ''Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.''; PubMed
  10. Goldfarb AN.; ''Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.''; PubMed
  11. Friedman AD.; ''Cell cycle and developmental control of hematopoiesis by Runx1.''; PubMed
  12. Török K, Dezső B, Bencsik A, Uzonyi B, Erdei A.; ''Complement receptor type 1 (CR1/CD35) expressed on activated human CD4+ T cells contributes to generation of regulatory T cells.''; PubMed
  13. Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A.; ''FOXP3 controls regulatory T cell function through cooperation with NFAT.''; PubMed
  14. Chimge NO, Frenkel B.; ''The RUNX family in breast cancer: relationships with estrogen signaling.''; PubMed
  15. Shigesada K, van de Sluis B, Liu PP.; ''Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11.''; PubMed
  16. Wang X, Blagden C, Fan J, Nowak SJ, Taniuchi I, Littman DR, Burden SJ.; ''Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle.''; PubMed
  17. Kanno T, Kanno Y, Chen LF, Ogawa E, Kim WY, Ito Y.; ''Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit.''; PubMed
  18. Kramer I, Sigrist M, de Nooij JC, Taniuchi I, Jessell TM, Arber S.; ''A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification.''; PubMed
  19. Tahirov TH, Inoue-Bungo T, Morii H, Fujikawa A, Sasaki M, Kimura K, Shiina M, Sato K, Kumasaka T, Yamamoto M, Ishii S, Ogata K.; ''Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.''; PubMed
  20. Maloy KJ, Powrie F.; ''Regulatory T cells in the control of immune pathology.''; PubMed
  21. Lukasik SM, Zhang L, Corpora T, Tomanicek S, Li Y, Kundu M, Hartman K, Liu PP, Laue TM, Biltonen RL, Speck NA, Bushweller JH.; ''Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis.''; PubMed
  22. Ichikawa M, Yoshimi A, Nakagawa M, Nishimoto N, Watanabe-Okochi N, Kurokawa M.; ''A role for RUNX1 in hematopoiesis and myeloid leukemia.''; PubMed
  23. Sakaguchi S.; ''Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.''; PubMed
  24. Boller S, Grosschedl R.; ''The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.''; PubMed
  25. Wu D, Ozaki T, Yoshihara Y, Kubo N, Nakagawara A.; ''Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation.''; PubMed
  26. Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G.; ''Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.''; PubMed
  27. Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q.; ''Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.''; PubMed
  28. Kobayashi A, Senzaki K, Ozaki S, Yoshikawa M, Shiga T.; ''Runx1 promotes neuronal differentiation in dorsal root ganglion.''; PubMed
  29. Lam K, Zhang DE.; ''RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.''; PubMed
  30. Shevach EM.; ''Regulatory T cells in autoimmmunity*.''; PubMed
  31. Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S.; ''Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.''; PubMed
  32. Ichikawa M, Asai T, Chiba S, Kurokawa M, Ogawa S.; ''Runx1/AML-1 ranks as a master regulator of adult hematopoiesis.''; PubMed
  33. Kim JH, Lee S, Rho JK, Choe SY.; ''AML1, the target of chromosomal rearrangements in human leukemia, regulates the expression of human complement receptor type 1 (CR1) gene.''; PubMed

History

View all...
CompareRevisionActionTimeUserComment
101540view11:40, 1 November 2018ReactomeTeamreactome version 66
101075view21:23, 31 October 2018ReactomeTeamreactome version 65
100605view19:57, 31 October 2018ReactomeTeamreactome version 64
100156view16:42, 31 October 2018ReactomeTeamreactome version 63
99706view15:10, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99287view12:46, 31 October 2018ReactomeTeamreactome version 62
93436view11:23, 9 August 2017ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CBFB ProteinQ13951 (Uniprot-TrEMBL)
CR1 gene ProteinENSG00000203710 (Ensembl)
CR1 geneGeneProductENSG00000203710 (Ensembl)
CR1ProteinP17927 (Uniprot-TrEMBL)
CTLA4 gene ProteinENSG00000163599 (Ensembl)
CTLA4 geneGeneProductENSG00000163599 (Ensembl)
CTLA4ProteinP16410 (Uniprot-TrEMBL)
FOXP3 Gene ProteinENSG00000049768 (Ensembl)
FOXP3 GeneGeneProductENSG00000049768 (Ensembl)
FOXP3 ProteinQ9BZS1 (Uniprot-TrEMBL)
FOXP3ProteinQ9BZS1 (Uniprot-TrEMBL)
IFNG gene ProteinENSG00000111537 (Ensembl)
IFNG geneGeneProductENSG00000111537 (Ensembl)
IFNGProteinP01579 (Uniprot-TrEMBL)
IL2 gene ProteinENSG00000109471 (Ensembl)
IL2 geneGeneProductENSG00000109471 (Ensembl)
IL2ProteinP60568 (Uniprot-TrEMBL)
IL2RA gene ProteinENSG00000134460 (Ensembl)
IL2RA geneGeneProductENSG00000134460 (Ensembl)
IL2RAProteinP01589 (Uniprot-TrEMBL)
NFATC2 ProteinQ13469 (Uniprot-TrEMBL)
NFATC2ProteinQ13469 (Uniprot-TrEMBL)
RUNX1 ProteinQ01196 (Uniprot-TrEMBL)
RUNX1:CBFB:CR1 geneComplexR-HSA-8939080 (Reactome)
RUNX1:CBFB:CTLA4 geneComplexR-HSA-8877405 (Reactome)
RUNX1:CBFB:FOXP3 geneComplexR-HSA-8865543 (Reactome)
RUNX1:CBFB:FOXP3:CTLA4 geneComplexR-HSA-8877413 (Reactome)
RUNX1:CBFB:FOXP3:IFNG geneComplexR-HSA-8877368 (Reactome)
RUNX1:CBFB:FOXP3:IL2RA geneComplexR-HSA-8877389 (Reactome)
RUNX1:CBFB:FOXP3:NFATC2:IL2 geneComplexR-HSA-8877349 (Reactome)
RUNX1:CBFB:FOXP3:TNFRSF18 geneComplexR-HSA-8877491 (Reactome)
RUNX1:CBFB:FOXP3ComplexR-HSA-8877193 (Reactome)
RUNX1:CBFB:IFNG geneComplexR-HSA-8877363 (Reactome)
RUNX1:CBFB:IL2RA geneComplexR-HSA-8877382 (Reactome)
RUNX1:CBFB:NFATC2:IL2 geneComplexR-HSA-8877341 (Reactome)
RUNX1:CBFB:TNFRSF18 geneComplexR-HSA-8877483 (Reactome)
RUNX1:CBFBComplexR-HSA-8865330 (Reactome)
TNFRSF18 gene ProteinENSG00000186891 (Ensembl)
TNFRSF18 geneGeneProductENSG00000186891 (Ensembl)
TNFRSF18ProteinQ9Y5U5 (Uniprot-TrEMBL)
Transcriptional regulation by RUNX1PathwayR-HSA-8878171 (Reactome) The RUNX1 (AML1) transcription factor is a master regulator of hematopoiesis (Ichikawa et al. 2004) that is frequently translocated in acute myeloid leukemia (AML), resulting in formation of fusion proteins with altered transactivation profiles (Lam and Zhang 2012, Ichikawa et al. 2013). In addition to RUNX1, its heterodimerization partner CBFB is also frequently mutated in AML (Shigesada et al. 2004, Mangan and Speck 2011).
The core domain of CBFB binds to the Runt domain of RUNX1, resulting in formation of the RUNX1:CBFB heterodimer. CBFB does not interact with DNA directly. The Runt domain of RUNX1 mediated both DNA binding and heterodimerization with CBFB (Tahirov et al. 2001), while RUNX1 regions that flank the Runt domain are involved in transactivation (reviewed in Zhang et al. 2003) and negative regulation (autoinhibition). CBFB facilitates RUNX1 binding to DNA by stabilizing Runt domain regions that interact with the major and minor grooves of the DNA (Tahirov et al. 2001, Backstrom et al. 2002, Bartfeld et al. 2002). The transactivation domain of RUNX1 is located C-terminally to the Runt domain and is followed by the negative regulatory domain. Autoinhibiton of RUNX1 is relieved by interaction with CBFB (Kanno et al. 1998).
Transcriptional targets of the RUNX1:CBFB complex involve genes that regulate self-renewal of hematopoietic stem cells (HSCs) (Zhao et al. 2014), as well as commitment and differentiation of many hematopoietic progenitors, including myeloid (Friedman 2009) and megakaryocytic progenitors (Goldfarb 2009), regulatory T lymphocytes (Wong et al. 2011) and B lymphocytes (Boller and Grosschedl 2014).
RUNX1 binds to promoters of many genes involved in ribosomal biogenesis (Ribi) and is thought to stimulate their transcription. RUNX1 loss-of-function decreases ribosome biogenesis and translation in hematopoietic stem and progenitor cells (HSPCs). RUNX1 loss-of-function is therefore associated with a slow growth, but at the same time it results in reduced apoptosis and increases resistance of cells to genotoxic and endoplasmic reticulum stress, conferring an overall selective advantage to RUNX1 deficient HSPCs (Cai et al. 2015).
RUNX1 is implicated as a tumor suppressor in breast cancer. RUNX1 forms a complex with the activated estrogen receptor alpha (ESR1) and regulates expression of estrogen-responsive genes (Chimge and Frenkel 2013).
RUNX1 is overexpressed in epithelial ovarian carcinoma where it may contribute to cell proliferation, migration and invasion (Keita et al. 2013).
RUNX1 may cooperate with TP53 in transcriptional activation of TP53 target genes upon DNA damage (Wu et al. 2013).
RUNX1 is needed for the maintenance of skeletal musculature (Wang et al. 2005).
During mouse embryonic development, Runx1 is expressed in most nociceptive sensory neurons, which are involved in the perception of pain. In adult mice, Runx1 is expressed only in nociceptive sensory neurons that express the Ret receptor and is involved in regulation of expression of genes encoding ion channels (sodium-gated, ATP-gated and hydrogen ion-gated) and receptors (thermal receptors, opioid receptor MOR and the Mrgpr class of G protein coupled receptors). Mice lacking Runx1 show defective perception of thermal and neuropathic pain (Chen CL et al. 2006). Runx1 is thought to activate the neuronal differentiation of nociceptive dorsal root ganglion cells during embryonal development possibly through repression of Hes1 expression (Kobayashi et al. 2012). In chick and mouse embryos, Runx1 expression is restricted to the dorso-medial domain of the dorsal root ganglion, to TrkA-positive cutaneous sensory neurons. Runx3 expression in chick and mouse embryos is restricted to ventro-lateral domain of the dorsal root ganglion, to TrkC-positive proprioceptive neurons (Chen AI et al. 2006, Kramer et al. 2006). RUNX1 mediated regulation of neuronally expressed genes will be annotated when mechanistic details become available.

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
CR1 geneR-HSA-8939082 (Reactome)
CR1 geneR-HSA-8939088 (Reactome)
CR1ArrowR-HSA-8939088 (Reactome)
CTLA4 geneR-HSA-8877404 (Reactome)
CTLA4 geneR-HSA-8877414 (Reactome)
CTLA4 geneR-HSA-8877421 (Reactome)
CTLA4ArrowR-HSA-8877421 (Reactome)
FOXP3 GeneR-HSA-8865546 (Reactome)
FOXP3 GeneR-HSA-8865547 (Reactome)
FOXP3ArrowR-HSA-8865546 (Reactome)
FOXP3R-HSA-8877192 (Reactome)
IFNG geneR-HSA-8877360 (Reactome)
IFNG geneR-HSA-8877369 (Reactome)
IFNG geneR-HSA-9006422 (Reactome)
IFNGArrowR-HSA-9006422 (Reactome)
IL2 geneR-HSA-8877338 (Reactome)
IL2 geneR-HSA-8877345 (Reactome)
IL2 geneR-HSA-8877348 (Reactome)
IL2ArrowR-HSA-8877345 (Reactome)
IL2RA geneR-HSA-8877385 (Reactome)
IL2RA geneR-HSA-8877391 (Reactome)
IL2RA geneR-HSA-8877396 (Reactome)
IL2RAArrowR-HSA-8877396 (Reactome)
NFATC2R-HSA-8877338 (Reactome)
NFATC2R-HSA-8877348 (Reactome)
R-HSA-8865546 (Reactome) Binding of the RUNX1:CBFB complex to the promoter of the FOXP3 gene stimulates FOXP3 transcription (Kitoh et al. 2009).
R-HSA-8865547 (Reactome) RUNX1, in complex with CBFB, binds to at least two regulatory elements in the promoter of the FOXP3 gene (Kitoh et al. 2009).
R-HSA-8877192 (Reactome) RUNX1 forms a complex with FOXP3. This interaction involves the C-terminus of RUNX1 and the FOXP3 region between the forkhead domain and the leucine zipper motif (Ono et al. 2007).
R-HSA-8877338 (Reactome) The complex of CBFB and RUNX1 (AML1) binds to the promoter of the IL2 gene in cooperation with NFATC2 (NFAT1). NFAT response element is adjacent to RUNX1 response element in the IL2 promoter (Ono et al. 2007).
R-HSA-8877345 (Reactome) The RUNX1:CBFB complex in cooperation with NFATC2 (NFAT1) stimulates transcription of the IL2 gene. In the presence of FOXP3, however, transcription of the IL2 gene is suppressed. Suppressed IL2 production is one of the hallmarks of regulatory T cells (Tregs) (Wu et al. 2006, Ono et al. 2007).
R-HSA-8877348 (Reactome) The complex of FOXP3 and RUNX1 (RUNX1 being consitutively associated with CBFB) can bind to the IL2 gene promoter in cooperation with NFATC2 (NFAT1). The NFAT response element is adjacent to RUNX1 response element in the IL2 promoter (Wu et al. 2006, Ono et al. 2007).
R-HSA-8877360 (Reactome) The RUNX1:CBFB complex binds to the interferon gamma (IFNG) gene promoter (Ono et al. 2007).
R-HSA-8877369 (Reactome) The complex of FOXP3 and the RUNX1:CBFB heterodimer binds the interferon gamma (IFNG) gene promoter (Ono et al. 2007).
R-HSA-8877385 (Reactome) The RUNX1:CBFB complex binds the first intron of the IL2RA (CD25) gene (Ono et al. 2007).
R-HSA-8877391 (Reactome) FOXP3 bound to the RUNX1:CBFB complex binds the first intron of the IL2RA (CD25) gene (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).
R-HSA-8877396 (Reactome) The RUNX1:CBFB complex inhibits transcription of the IL2RA (CD25) gene. Once FOXP3 binds to RUNX1, transcription of the IL2RA gene is stimulated. High IL2RA expression at the cell surface is one of the hallmarks of regulatory T cells (Tregs) (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).
R-HSA-8877404 (Reactome) The RUNX1:CBFB complex binds the promoter of the CTLA4 gene (Ono et al. 2007).
R-HSA-8877414 (Reactome) The complex of FOXP3 and the RUNX1:CBFB heterodimer binds the promoter of the CTLA4 gene (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).
R-HSA-8877421 (Reactome) Binding of the RUNX1:CBFB complex to the promoter of the CTLA4 gene inhibits CTLA4 transcription. Once FOXP3 is associated with RUNX1, the CTLA4 gene transcription is stimulated. High cells surface level of CTLA4 is one of the hallmarks of regulatory T cells (T regs) (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).
R-HSA-8877485 (Reactome) The RUNX1:CBFB complex binds to the promoter and the first intron of the TNFRSF18 (GITR) gene (Ono et al. 2007).
R-HSA-8877490 (Reactome) FOXP3 bound to the RUNX1:CBFB complex binds to the first intron of the TNFRSF18 (GITR) gene (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).
R-HSA-8877493 (Reactome) Binding of FOXP3 in complex with RUNX1 to the first intron of the TNFRSF18 (GITR) gene stimulates TNFRSF18 transcription. When FOXP3 is not present, RUNX1 inhibits TNFRSF18 transcription. High level of TNFRSF18 at the cell surface is one of the hallmarks of regulatory T cells (Tregs) (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).
R-HSA-8939082 (Reactome) The RUNX1:CBFB complex binds the promoter of the CR1 (CD35) gene, encoding Complement receptor type 1 (Kim et al. 1999, Rho et al. 2002).
R-HSA-8939088 (Reactome) Binding of the RUNX1:CBFB complex to the promoter of the CR1 (CD35) gene stimulates CR1 transcription. The CR1 gene encodes Complement receptor type 1. Binding of an ETS family member to an ETS site adjacent to the RUNX1 site in the CR1 gene promoter probably contributes to CR1 expression (Kim et al. 1999, Rho et al. 2004).
R-HSA-9006422 (Reactome) Binding of the RUNX1:CBFB complex to the interferon gamma (IFNG) gene promoter stimulates IFNG transcription. If FOXP3 is present in the complex with RUNX1, the IFNG gene transcription is inhibited. Suppressed IFNG production is one of the hallmarks of regulatory T cells (Tregs) (Ono et al. 2007).
RUNX1:CBFB:CR1 geneArrowR-HSA-8939082 (Reactome)
RUNX1:CBFB:CR1 geneArrowR-HSA-8939088 (Reactome)
RUNX1:CBFB:CTLA4 geneArrowR-HSA-8877404 (Reactome)
RUNX1:CBFB:CTLA4 geneTBarR-HSA-8877421 (Reactome)
RUNX1:CBFB:FOXP3 geneArrowR-HSA-8865546 (Reactome)
RUNX1:CBFB:FOXP3 geneArrowR-HSA-8865547 (Reactome)
RUNX1:CBFB:FOXP3:CTLA4 geneArrowR-HSA-8877414 (Reactome)
RUNX1:CBFB:FOXP3:CTLA4 geneArrowR-HSA-8877421 (Reactome)
RUNX1:CBFB:FOXP3:IFNG geneArrowR-HSA-8877369 (Reactome)
RUNX1:CBFB:FOXP3:IFNG geneTBarR-HSA-9006422 (Reactome)
RUNX1:CBFB:FOXP3:IL2RA geneArrowR-HSA-8877391 (Reactome)
RUNX1:CBFB:FOXP3:IL2RA geneArrowR-HSA-8877396 (Reactome)
RUNX1:CBFB:FOXP3:NFATC2:IL2 geneArrowR-HSA-8877348 (Reactome)
RUNX1:CBFB:FOXP3:NFATC2:IL2 geneTBarR-HSA-8877345 (Reactome)
RUNX1:CBFB:FOXP3:TNFRSF18 geneArrowR-HSA-8877490 (Reactome)
RUNX1:CBFB:FOXP3:TNFRSF18 geneArrowR-HSA-8877493 (Reactome)
RUNX1:CBFB:FOXP3ArrowR-HSA-8877192 (Reactome)
RUNX1:CBFB:FOXP3R-HSA-8877348 (Reactome)
RUNX1:CBFB:FOXP3R-HSA-8877369 (Reactome)
RUNX1:CBFB:FOXP3R-HSA-8877391 (Reactome)
RUNX1:CBFB:FOXP3R-HSA-8877414 (Reactome)
RUNX1:CBFB:FOXP3R-HSA-8877490 (Reactome)
RUNX1:CBFB:IFNG geneArrowR-HSA-8877360 (Reactome)
RUNX1:CBFB:IFNG geneArrowR-HSA-9006422 (Reactome)
RUNX1:CBFB:IL2RA geneArrowR-HSA-8877385 (Reactome)
RUNX1:CBFB:IL2RA geneTBarR-HSA-8877396 (Reactome)
RUNX1:CBFB:NFATC2:IL2 geneArrowR-HSA-8877338 (Reactome)
RUNX1:CBFB:NFATC2:IL2 geneArrowR-HSA-8877345 (Reactome)
RUNX1:CBFB:TNFRSF18 geneArrowR-HSA-8877485 (Reactome)
RUNX1:CBFB:TNFRSF18 geneTBarR-HSA-8877493 (Reactome)
RUNX1:CBFBR-HSA-8865547 (Reactome)
RUNX1:CBFBR-HSA-8877192 (Reactome)
RUNX1:CBFBR-HSA-8877338 (Reactome)
RUNX1:CBFBR-HSA-8877360 (Reactome)
RUNX1:CBFBR-HSA-8877385 (Reactome)
RUNX1:CBFBR-HSA-8877404 (Reactome)
RUNX1:CBFBR-HSA-8877485 (Reactome)
RUNX1:CBFBR-HSA-8939082 (Reactome)
TNFRSF18 geneR-HSA-8877485 (Reactome)
TNFRSF18 geneR-HSA-8877490 (Reactome)
TNFRSF18 geneR-HSA-8877493 (Reactome)
TNFRSF18ArrowR-HSA-8877493 (Reactome)
Personal tools