Eukaryotic Transcription Initiation (Homo sapiens)

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1, 25'3'Steps 2) Association of TIFs and RNA polymeraseTFIIB3'(mRNA, snRNPs)TFIIATATA Box bindingproteindsDNATFIIF3'3'TFIIFTFIIHRNA polymerase III3'RNA polymerase I5'Steps 5) RNA elongation with CDT phosphorylation(large ribosomal RNAs)3'5'RNA pol II5'5'Steps 4) Transcription elongation by NTPsTFIIE(small stable RNAs)Steps 1) TBP binds TATA box5'Transcription Initiation Factors (TIFs)RNA polymerase II5'TFIIH5'3'TFIIATFIIETATA5'5'TATA(recognize surface DNA geometry)TATATFIIDTFIIB3'Gene Regulatory Proteinscell growthTFIIDPrimary RNA transcriptSteps 3) DNA melting by association with TFIIHTFIIF3'GTF2H4TAF7POLR2KTAF12POLR2BGTF2A2Polr1eTBPERCC3POLR2EPOLR3ETAF6POLR3HPOLR2CMNAT1POLR3DPOLR1DGTF2F2POLR1BPOLR3KGTF2H2POLR3BTAF9ILKPOLR2JCDK7POLR2GGTF2H1GTF2E1CCNHGTF2BPOLR2HPOLR2IPOLR1ATAF5POLR2AGTF2H3GTF2E2POLR2FERCC2TAF13


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. (Source: Wikipedia)


Pathway source: http://www.web-books.com/MoBio/Free/Ch4E.htm

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Ontology Terms

 

Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed

History

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94824view03:02, 6 October 2017KhanspersModified description
94823view03:02, 6 October 2017KhanspersModified description
94822view03:02, 6 October 2017Khanspersremoved GenMAPP notes
94821view03:01, 6 October 2017Khanspersconnected lines
88988view11:31, 18 August 2016MirellaKalafatiOntology Term : 'PW:0000004' removed !
88903view08:30, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
73594view19:47, 3 February 2014MaintBotSpecify description
73593view19:46, 3 February 2014MaintBotRemoving extraneous group causing rendering issue
63187view20:46, 8 May 2013MaintBotUpdating gpml version
41116view23:36, 1 March 2011MaintBotRemoved redundant pathway information and comments
37350view18:09, 28 May 2010Khanspersconnectors
35509view13:47, 12 February 2010Thomasremoved genmapp remark
35508view13:46, 12 February 2010Thomasadded literature
35507view13:44, 12 February 2010ThomasModified description
34503view23:29, 16 December 2009KhanspersAdded connectors
34471view18:33, 10 December 2009MaintBotAutomatic update of empty xrefs
32424view17:10, 15 August 2009MaintBotFixed text labels
32083view13:40, 14 August 2009MaintBotFixed group labels
29565view08:45, 18 May 2009LauravanzonPeriodical save, work in progress
26587view18:26, 10 December 2008AlexanderPico
21534view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:RNA transcription Reactome]] moved to [[Pathway:WP405]]: Moved to stable identifier
14949view16:18, 24 May 2008MartijnVanIerselcreated groups
13006view11:05, 17 May 2008MaintBotSticky edges patch by Sjoerd
8366view13:46, 7 January 2008MaintBot[[Pathway:Human:RNA transcription Reactome]] moved to [[Pathway:Homo sapiens:RNA transcription Reactome]]: Renaming species
7801view16:18, 18 December 2007MaintBotfixed category names
7286view12:41, 4 November 2007MaintBotAdded categories to GPML
6365view22:18, 22 May 2007Nsalomonisgpml file for [[Human:RNA_transcription_Reactome]]

External references

DataNodes

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NameTypeDatabase referenceComment
CCNHGeneProduct902 (Entrez Gene)
CDK7GeneProduct1022 (Entrez Gene)
ERCC2GeneProduct2068 (Entrez Gene)
ERCC3GeneProduct2071 (Entrez Gene)
GTF2A2GeneProduct2958 (Entrez Gene)
GTF2BGeneProduct2959 (Entrez Gene)
GTF2E1GeneProduct2960 (Entrez Gene)
GTF2E2GeneProduct2961 (Entrez Gene)
GTF2F2GeneProduct2963 (Entrez Gene)
GTF2H1GeneProduct2965 (Entrez Gene)
GTF2H2GeneProduct2966 (Entrez Gene)
GTF2H3GeneProduct2967 (Entrez Gene)
GTF2H4GeneProduct2968 (Entrez Gene)
ILKGeneProduct3611 (Entrez Gene)
MNAT1GeneProduct4331 (Entrez Gene)
POLR1AGeneProduct25885 (Entrez Gene)
POLR1BGeneProduct84172 (Entrez Gene)
POLR1DGeneProduct51082 (Entrez Gene)
POLR2AGeneProduct5430 (Entrez Gene)
POLR2BGeneProduct5431 (Entrez Gene)
POLR2CGeneProduct5432 (Entrez Gene)
POLR2EGeneProduct5434 (Entrez Gene)
POLR2FGeneProduct5435 (Entrez Gene)
POLR2GGeneProduct5436 (Entrez Gene)
POLR2HGeneProduct5437 (Entrez Gene)
POLR2IGeneProduct5438 (Entrez Gene)
POLR2JGeneProduct5439 (Entrez Gene)
POLR2KGeneProduct5440 (Entrez Gene)
POLR3BGeneProduct55703 (Entrez Gene)
POLR3DGeneProduct661 (Entrez Gene)
POLR3EGeneProduct55718 (Entrez Gene)
POLR3HGeneProduct171568 (Entrez Gene)
POLR3KGeneProduct51728 (Entrez Gene)
Polr1eGeneProduct64425 (Entrez Gene)
TAF12GeneProduct6883 (Entrez Gene)
TAF13GeneProduct6884 (Entrez Gene)
TAF5GeneProduct6877 (Entrez Gene)
TAF6GeneProduct6878 (Entrez Gene)
TAF7GeneProduct6879 (Entrez Gene)
TAF9GeneProduct6880 (Entrez Gene)
TBPGeneProduct6908 (Entrez Gene)

Annotated Interactions

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