Nucleotide Metabolism (Homo sapiens)

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PolyamineSynthesisNDPsDNADNA SynthesisdNTPsdNDPsIMPDH1SAICARPOLGNME2POLD1SATOrnithinePOLBXanthine monophosphateADSLSpermineGuanineHypoxanthinePRPS2AdenineRRM2MTHFD2SRMAICARPRPPUric AcidRRM1ADSSSpermidineAdenylosuccinateHPRT1POLAGMPPRPS1PutrescineRRM2BIMPGMPRiboseOAZ1AMPRRM1GMPDHFR


The pathway outlined above focuses on purine metabolism and in particular that of guanine metabolism.

Quality Tags

Ontology Terms



No bibliography


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68960view17:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
45328view20:14, 7 October 2011KhanspersOntology Term : 'PW:0000012' removed !
45327view20:14, 7 October 2011KhanspersOntology Term : 'purine metabolic pathway' added !
45326view20:14, 7 October 2011KhanspersOntology Term : 'nucleotide metabolic pathway' added !
41126view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
38837view17:22, 24 September 2010Khanspers
38782view00:19, 24 September 2010KhanspersChanged line types
35286view22:50, 11 February 2010MjhModified description
32995view19:01, 30 September 2009MaintBotchanged unknowns to metabolites
32423view17:09, 15 August 2009MaintBotFixed text labels
32082view13:39, 14 August 2009MaintBotFixed group labels
21532view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Nucleotide Metabolism]] moved to [[Pathway:WP404]]: Moved to stable identifier
14016view18:02, 20 May 2008Thomasadded RRM2/RRM2B alternative route
14013view17:47, 20 May 2008Thomasadded some metabolites and connected lines
14011view17:41, 20 May 2008ThomasPeriodical save, work in progress
13100view11:15, 17 May 2008MaintBotautomated metabolite conversion
11557view01:30, 11 April 2008Txr24RNR substrate, subunit and product fix
8302view13:46, 7 January 2008MaintBot[[Pathway:Human:Nucleotide Metabolism]] moved to [[Pathway:Homo sapiens:Nucleotide Metabolism]]: Renaming species
7771view16:16, 18 December 2007MaintBotfixed category names
7384view12:42, 4 November 2007MaintBotAdded categories to GPML
6358view22:18, 22 May 2007N.Fidelmangpml file for [[Human:Nucleotide_Metabolism]]

External references


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NameTypeDatabase referenceComment
ADSLGeneProduct158 (Entrez Gene)
ADSSGeneProduct159 (Entrez Gene)
AICARMetabolite3031-94-5 (CAS)
AMPMetaboliteHMDB03540 (HMDB)
AdenineMetabolite73-24-5 (CAS)
AdenylosuccinateMetabolite15919 (ChEBI)
DHFRGeneProduct1719 (Entrez Gene)
GMPMetabolite85-32-5 (CAS)
GuanineMetabolite73-40-5 (CAS)
HPRT1GeneProduct3251 (Entrez Gene)
HypoxanthineMetabolite68-94-0 (CAS)
IMPMetabolite17202 (ChEBI)
IMPDH1GeneProduct3614 (Entrez Gene)
MTHFD2GeneProduct10797 (Entrez Gene)
NME2GeneProduct4831 (Entrez Gene)
OAZ1GeneProduct4946 (Entrez Gene)
OrnithineMetabolite70-26-8 (CAS)
POLAGeneProduct5422 (Entrez Gene)
POLBGeneProduct5423 (Entrez Gene)
POLD1GeneProduct5424 (Entrez Gene)
POLGGeneProduct5428 (Entrez Gene)
PRPPMetabolite97-55-2 (CAS)
PRPS1GeneProduct5631 (Entrez Gene) Mouse: AA110812
PRPS2GeneProduct5634 (Entrez Gene)
PutrescineMetabolite110-60-1 (CAS)
RRM1GeneProduct6240 (Entrez Gene)
RRM2GeneProduct6241 (Entrez Gene)
RRM2BGeneProduct50484 (Entrez Gene)
RiboseMetabolite50-69-1 (CAS)
SAICARMetabolite3031-95-6 (CAS)
SATGeneProduct6303 (Entrez Gene)
SRMGeneProduct6723 (Entrez Gene)
SpermidineMetabolite124-20-9 (CAS)
SpermineMetabolite71-44-3 (CAS)
Uric AcidMetabolite69-93-2 (CAS)
Xanthine monophosphateMetabolite69-89-6 (CAS)

Annotated Interactions

No annotated interactions

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