PTEN Regulation (Homo sapiens)

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1-6, 8-10, 13...4321, 352126, 54433, 5866, 67693, 11, 19, 22, 29...6931696, 6819, 294111, 4253, 644, 14, 18, 41, 59...451, 576934, 36, 5614, 18, 59, 672, 7, 9, 15, 17...446931473, 69930436922, 403, 5855, 6238369243, 697041373446615, 4930436932, 61626925, 32nucleoplasmcytosollysosomal membraneEIF2C4 TNRC6B PTEN gene miR-20b miR-19b RISC:CNOT6LmRNAMOV10 EIF2C3 CBX2 UbUBC(609-684) EIF2C1 EIF2C3 EIF2C4 miR-17 EIF2C3 Casein kinase IIATN1 UBA52(1-76) EIF2C1 UBC(381-456) USP13,OTUD3TNRC6B PTEN mRNA p-T185,Y187-MAPK1 PSMD4 TNRC6B HDAC1 MLST8 PSMD1 AGO2 UBB(77-152) EIF2C3 SNAI1 PSMD10 26S proteasomeEIF2C3 TNKS2 UBA52(1-76) UBC(229-304) miR-19b1 HDAC1 NR2E1 UBB(1-76) TNRC6A PPARG miR-17 RISC:CNOT6LmRNAEZH2 EIF2C1 PTEN, p-3S,2T-PTENMOV10 UBC(609-684) UBB(153-228) PSMA5 TNRC6A PPARG NEDD4 miR-214NonendonucleolyticRISCEIF2C3 UBC(153-228) miR-19a MAF1 ADPPTEN miR-20 RISC:VAPAmRNARPTOR AGO2 Actos PSMD9 VAPA mRNA UBC(381-456) PSMD8 NR2E1 BMI1 NR2E1:(CoRESTcomplex,ATN1,HDAC3,HDAC5,HDAC7):PTEN GeneMTA1 EIF2C1 PSMB7 UBC(229-304) UBC(229-304) UBB(153-228) EIF2C1 PSMB4 EIF2C1 EIF2C3 TNRC6C miR-106 RISC:PTENmRNATNRC6A TNRC6C EIF2C3 MECOM:PTEN genePSME3 PTENP1 mRNAPolyUb-PTEN,K48polyUb-K289-PTENUbSTUB1 MBD3 EIF2C3 PSMB5 EIF2C4 AGO2 UBB(153-228) VAPA mRNA UBC(457-532) TRIM27 EIF2C1 UBC(381-456) TNRC6C TP53 TNRC6A TNRC6B RPS27A(1-76) XIAP RBBP7 EIF2C3 TNRC6A RGZ miR-25 TNRC6C TNRC6C RPS27A(1-76) PHC1 UBC(229-304) AGO2 MOV10 miR-25 MOV10 miR-19a UBC(457-532) TNRC6B TNRC6B TNRC6B PTEN gene MOV10 miR-20b SNAI2 EIF2C1 RPS27A(1-76) TNRC6A CNOT6L mRNATNRC6A UBA52(1-76) TNRC6C miR-205 p-T305,S472-AKT3 RBBP7 TNRC6B NEDD4 RibC-E40,E150,D326-PTENMOV10 AGO2 TNRC6B EIF2C1 ADPmiR-106a PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTENp-Y387-FRKTNRC6C MBD3 miR-19b RISC:PTENP1mRNATNRC6C TNRC6A TNRC6A mTORC1:Ragulator:Rag:GNP:RHEB:GTPRING1 miR-25 RISC:PTENmRNAPSMD3 AGO2 miR-19a RISCUBC(533-608) TNRC6B EIF2C3 CNOT6L mRNA TNRC6A TNRC6A CBX4 UBC(609-684) TNRC6C USP7TNRC6C MOV10 RNF2 miR-26A2 UBC(1-76) UBC(381-456) PHC2 AGO2 PSMD11 UBC(229-304) TP53 PTEN gene EIF2C1 JUN:PTEN geneEIF2C4 TNRC6B LAMTOR5 OTUD3 EIF2C4 GDP EIF2C3 miR-21 PSME2 UbEIF2C4 VAPA mRNA RING1 TNRC6B PHC3 REST KDM1A TNRC6C PSMA7 TNRC6B miR-205 RISCUBB(153-228) MTA2 TNRC6B UBC(77-152) CBX4 PHC1 UBB(1-76) MOV10 PPARG:Fatty AcidLigand:PTEN geneUBC(609-684) HDAC2 HDAC2 EIF2C1 EIF2C3 LAMTOR4 TNRC6C EIF2C3 UBC(1-76) PREX2:PTEN,p-3S,2T-PTENPSMD5 TNRC6A UBC(1-76) AGO2 UBC(77-152) GATAD2B TNRC6A WWP2 UBB(77-152) p-T69,T71-ATF2:PTENgenep-Y387-FRK PTEN gene EGR1 JUN miR-19b2 SNAI1,SNAI2:PTENgeneNAMPSMC4 MOV10 miR-20b miR-19a RISC:VAPAmRNACSNK2A1 UBC(1-76) miR-21 EIF2C1 EIF2C4 AGO2 UBC(533-608) AGO2 AGO2 EIF2C1 EIF2C4 LAMTOR2 SLC38A9 UBC(153-228) EIF2C4 TNRC6A TNRC6B miR-17 TNRC6B GATAD2A PTEN PSMA6 SCMH1-2 EIF2C3 UBB(153-228) TNRC6A EIF2C1 miR-22 RISCTNRC6C TNRC6C EIF2C3 miR-106b TNRC6C TNRC6C PTEN mRNA XIAP EIF2C4 EIF2C1 CHD3 PSMB8 p-3S,2T-PTEN RBBP7 EIF2C4 Actos SHFM1 AGO2 EIF2C3 UBB(77-152) UBC(457-532) MOV10 MAF1:PTEN geneCBX2 UBC(609-684) TNRC6B RBBP7 TNRC6C CNOT6L mRNA miR-106a NEDD4,STUB1,WWP2 andXIAPmiR-20a UBC(77-152) miR-19a RISC:CNOT6LmRNATNRC6C miR-106b miR-20 RISC:CNOT6LmRNAMOV10 EIF2C1 PSMB1 MOV10 miR-21NonendonucleolyticRISCPHC2 MOV10 p-T309,S474-AKT2 EIF2C3 MOV10 EIF2C3 ADPPTEN mRNA miR-93 PPARG:Fatty AcidLigandAGO2 TNRC6B CNOT6L mRNA MOV10 EIF2C1 EIF2C3 PTEN mRNA MOV10 RBBP4 miR-17 RISC:PTENmRNARBBP4 TNRC6C PTEN gene EED EGR1:PTEN genePSMB3 miR-25 RISCMOV10 RRAGA PSMC1 MAF1PSMB10 AGO2 MTA2 UBC(77-152) MTA3 K27polyUb-PTENmiR-205 RISC:PTENmRNAUBC(153-228) miR-19b2 PSME4 LAMTOR1 GATAD2A PTEN mRNA UBC(305-380) EIF2C3 PTEN:p-Y387-FRKTNRC6C EIF2C4 MOV10 PREX2PSMD6 MOV10 SNAI1 CNOT6L mRNA UBC(153-228) CHD4 EIF2C1 TNRC6C AGO2 UBC(153-228) PTEN:TRIM27MOV10 EIF2C1 PTEN gene TNRC6A TNRC6B TNRC6A TNRC6C TNRC6B EIF2C3 miR-21NonendonucleolyticRISC:PTEN mRNAK48polyUb-K289-PTENEIF2C4 EZH2 MOV10 UBC(457-532) VAPA mRNARPS27A(1-76) MOV10 EIF2C4 13(S')-HODE SALL4MOV10 RCOR1 TNRC6C MOV10 AGO2 H2OTNRC6C TNRC6B EIF2C4 miR-93 RRAGC miR-17 H2OK48polyUb-K289-PTEN p-S109-MKRN1TNRC6B UBB(77-152) EIF2C4 miR-20 RISCmiR-19b RISC:PTENmRNARNF2 EIF2C4 TNRC6A miR-214 EIF2C4 SUZ12 TNRC6B SNAI1,SNAI2p-Y336-PTENCSNK2A2 UBC(533-608) EIF2C1 EIF2C4 p-T69,T71-ATF2NuRD complexTNRC6A EIF2C4 9S-HODE miR-19a TNRC6A PSMC5 TP53 TetramerTNRC6C 13(S')-HODE miR-26A1 PTENP1 mRNA RHEB RGZ UBA52(1-76) RCOR1 MOV10 UBC(457-532) EIF2C1 AGO2 PREX2 miR-26A2 TP53 Tetramer:PTENGeneSALL4 MOV10 MonoUb-K13,K289-PTENmiR-20a EIF2C1 PolyUb-PTENPRC1.4,PRC2 (EZH2)coremiR-106b PTENp-T69,T71-ATF2 TRIM27RBBP4 PTEN mRNA TNRC6A UBB(1-76) RRAGD RPS27A(1-76) TNRC6B PTEN gene UBA52(1-76) UBC(305-380) miR-20 RISC:PTENmRNAMonoUb-K13,K289-PTENUBC(457-532) PIP3 activates AKTsignalingPSME1 ATPUbTNRC6B TNRC6B PSMD2 miR-19a RISC:PTENmRNAEIF2C3 AGO2 PTEN mRNA AGO2 PSMC2 miR-214 TNRC6A p-3S,2T-PTENPTEN mRNA GATAD2B UBB(77-152) TNRC6B PHC3 TNRC6A PSMD14 EIF2C4 EIF2C3 MOV10 MECOM:(PRC1.4,PRC2(EZH2) core):PTENgenemiR-20a PTEN mRNA RRAGB EIF2C4 p-T,p-S-AKTEIF2C1 EGR1ADPHDAC1 MOV10 PTEN gene AGO2 UBC(229-304) PTENP1 mRNA MAF1miR-17 miR-106a CBX6 EIF2C4 ATPUBC(77-152) TNRC6C EIF2C3 UBB(153-228) MOV10 EIF2C3 AGO2 CBX8 PSMA4 RPS27A(1-76) UBC(381-456) EIF2C1 PSMB9 PTEN mRNA:miR-26ARISCTNRC6A EIF2C4 SUZ12 miR-22 miR-20 RISC:PTENP1mRNATNRC6A AGO2 9S-HODE EIF2C4 p-3S,2T-PTEN EIF2C4 UBC(305-380) USP13 TNRC6A EIF2C4 NAD+TNRC6A PSMB11 PTEN gene SALL4:NuRD:PTEN geneEIF2C3 PMLAGO2 KDM1A miR-19b1 TNRC6A PTENEIF2C3 MOV10 p-T,Y MAPK dimersTNRC6C miR-17 RISCmiR-205 PolyUb-PTEN TNRC6C UBC(305-380) UBC(305-380) RBBP4 miR-20b MOV10 SCMH1-2 AGO2 AGO2 EIF2C1 EIF2C4 EIF2C1 MECOM UBC(533-608) BMI1 PSMA3 miR-19b1 miR-19b2 UBC(1-76) p-S60,S68,S75-MAF1AGO2 miR-17 RISC:VAPAmRNACBX6 VAPA mRNA PTEN mRNA CSNK2B MOV10 p-T308,S473-AKT1 TNRC6B RNF146EIF2C3 UBC(1-76) TNKS1/2PTEN mRNA TNRC6C miR-106 RISC:VAPAmRNAmiR-106a UBC(381-456) TNRC6A TNRC6C UBA52(1-76) MECOM TNRC6A HDAC2 miR-19b1 UBC(153-228) TNRC6A UbEIF2C3 JUNPTEN gene AGO2 PSMB2 EIF2C3 PolyUb-PTEN CHD3 UBC(77-152) CHD4 TNKS EIF2C4 PSMA2 HDAC3,5,7 ATPHDAC3,5,7 EIF2C1 REST EIF2C1 TNRC6A miR-93:PTEN mRNAUBC(533-608) MTA1 SNAI2 miR-19b RISCEIF2C1 SALL4:PTEN genePTEN PSMD13 ATN1 MKRN1UBB(1-76) PTEN mRNAPSMC6 PSMB6 XIAP,NEDD4TNRC6A PSMA1 CNOT6L mRNA AGO2 miR-214NonendonucleolyticRISC:PTEN mRNATNRC6B miR-19b2 miR-106 RISC:CNOT6LmRNAUBC(305-380) EIF2C3 AGO2 EIF2C1 K48polyUb-K289-PTEN MTA3 miR-19a TNRC6C TNRC6A TNRC6B LAMTOR3 EIF2C3 EIF2C1 EIF2C1 UBB(1-76) CBX8 PTEN geneGTP TNRC6C MTOR SALL4 EIF2C4 UBB(1-76) EIF2C1 HDAC1 miR-20b MOV10 UBC(609-684) EED NR2E1:(CoRESTcomplex,ATN1,HDAC3,HDAC5,HDAC7)TNRC6B TNRC6A MOV10 EIF2C1 PSMD7 PSMA8 UbPolyUb-PTEN,K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTENmiR-20a PTEN gene PTEN MECOMmiR-26A1 EIF2C4 TNRC6B ATPHDAC2 PSMC3 TNRC6B EIF2C1 UBB(77-152) AGO2 EIF2C4 TNRC6C EIF2C3 PSMF1 EIF2C4 PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN p-T202,Y204-MAPK3 PSMD12 EIF2C3 TNRC6C miR-106b PTEN mRNA PTEN gene MOV10 miR-20a TNRC6C miR-26A RISCAGO2 miR-93 RISCmiR-22 EIF2C4 miR-22 RISC:PTENmRNAmiR-106 RISCTNRC6B UBC(533-608) EIF2C4 TNRC6B 32, 6151, 576237326, 54696920, 607051, 5711, 422951, 57696034, 36, 56696925, 324546953, 6431433, 5815, 4919, 2945474443, 69693693, 58312, 6334, 36, 5643433, 693855, 6269 vg >