Wnt Signaling Pathway (Mus musculus)

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1Ubiquitin TaggedB - CateninPhosphorylatedFrizzled LigandsCytoskeleton26S Proteasome Degredation-CateninTranscriptional ActivationNucleusPRecruitment to UnknownUbiquitin Conjugating EnzymeBPrkcqWnt10bPrkcaAxin1Fzd3Csnk1eFzd8Frat1Fzd10LdlrTCF-1/LEFWnt11Fosl1Prkd1Wnt5aPafah1b1Wnt1Wnt7aDvl1Fzd9Wnt4Wnt2Wnt16ApcCtnnb1Mapk9Ccnd1PrkcbPrkciFzd5Wnt16Fzd6Gsk3bPrkccPrkchWnt5bSfrp4Wnt6Wnt7bCcnd3Wnt3aFzd1MycWnt2bRac1Wnt10aPrkcdApoptosisFzd2Dvl2Ppp2r5cDvl3Fzd7Ppp2r5eWnt3Fbxw2RhoaPrkceMapk10JunPrkczCcnd2Plau


Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.


This pathway was inferred from Homo sapiens pathway WP428(r28695) with a 98% conversion rate.

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Ontology Terms



  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia


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89969view18:31, 6 October 2016Mkutmonfix unconnected lines
72349view03:30, 11 November 2013AriuttaAdded identifers
71734view20:17, 17 October 2013MaintBotAutomated update of data sources
69785view13:19, 11 July 2013Cizarfix unconnected lines and used nucleus template
69116view18:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67751view11:58, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
41302view00:23, 2 March 2011MaintBotRemoved redundant pathway information and comments
35124view13:31, 11 February 2010Thomasconnected line
35115view13:22, 11 February 2010Thomasadded literature
35106view13:14, 11 February 2010ThomasModified description
32422view17:09, 15 August 2009MaintBotFixed text labels
32081view13:39, 14 August 2009MaintBotFixed group labels
31447view21:09, 13 August 2009MaintBotFixed text labels
30857view00:09, 30 July 2009MaintBotConverted from Homo sapiens
21530view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Wnt Signaling]] moved to [[Pathway:WP403]]: Moved to stable identifier
8490view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Wnt Signaling]] moved to [[Pathway:Mus musculus:Wnt Signaling]]: Renaming species
7861view16:24, 18 December 2007MaintBotfixed category names
7316view12:42, 4 November 2007MaintBotAdded categories to GPML
6510view22:19, 22 May 2007M.Liebermangpml file for [[Mouse:Wnt_Signaling]]

External references


View all...
NameTypeDatabase referenceComment
ApcGeneProduct11789 (Entrez Gene)
ApoptosisPathway1254 (WikiPathways)
Axin1GeneProduct12005 (Entrez Gene)
Ccnd1GeneProduct12443 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Csnk1eGeneProduct27373 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Dvl1GeneProduct13542 (Entrez Gene)
Dvl2GeneProduct13543 (Entrez Gene)
Dvl3GeneProduct13544 (Entrez Gene)
Fbxw2GeneProduct30050 (Entrez Gene)
Fosl1GeneProduct14283 (Entrez Gene)
Frat1GeneProduct14296 (Entrez Gene)
Fzd10GeneProduct93897 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Fzd3GeneProduct14365 (Entrez Gene)
Fzd5GeneProduct14367 (Entrez Gene)
Fzd6GeneProduct14368 (Entrez Gene)
Fzd7GeneProduct14369 (Entrez Gene)
Fzd8GeneProduct14370 (Entrez Gene)
Fzd9GeneProduct14371 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene) MOUSE:KG38 MOUSE
JunGeneProduct16476 (Entrez Gene)
LdlrGeneProduct16835 (Entrez Gene)
Mapk10GeneProduct26414 (Entrez Gene)
Mapk9GeneProduct26420 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
Pafah1b1GeneProduct18472 (Entrez Gene)
PlauGeneProduct18792 (Entrez Gene)
Ppp2r5cGeneProduct26931 (Entrez Gene)
Ppp2r5eGeneProduct26932 (Entrez Gene)
PrkcaGeneProduct18750 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
PrkccGeneProduct18752 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene)
PrkchGeneProduct18755 (Entrez Gene)
PrkciGeneProduct18759 (Entrez Gene)
PrkcqGeneProduct18761 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
Prkd1GeneProduct18760 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Sfrp4GeneProduct20379 (Entrez Gene)
Wnt10aGeneProduct22409 (Entrez Gene)
Wnt10bGeneProduct22410 (Entrez Gene)
Wnt11GeneProduct22411 (Entrez Gene)
Wnt1GeneProduct22408 (Entrez Gene)
Wnt16GeneProduct93735 (Entrez Gene)
Wnt2GeneProduct22413 (Entrez Gene)
Wnt2bGeneProduct22414 (Entrez Gene)
Wnt3GeneProduct22415 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt4GeneProduct22417 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
Wnt5bGeneProduct22419 (Entrez Gene)
Wnt6GeneProduct22420 (Entrez Gene)
Wnt7aGeneProduct22421 (Entrez Gene)
Wnt7bGeneProduct22422 (Entrez Gene)

Annotated Interactions

No annotated interactions
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