DNA IR-damage and cellular response via ATR (Homo sapiens)

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76, 124, 130, 198, 354...186, 222, 226661104, 425467102, 261, 584170, 612625314187144, 229, 253, 365, 55268, 103, 105, 117, 466...401366, 500348, 502, 5838, 33559325981564718552364144167501108694395380455221, 361, 65785102, 5559375375314517369297525728288102694287508344104, 574, 65044427268823826194, 697296138, 558340211425175156, 207, 327, 376, 44361828138062988469706366, 518503552154, 397, 430227648196, 36633602316260297213, 70693DNA DSBsATR-ATRIPcomplexRecQ-like helicasesIonizing Radiation (IR)ssDNALegend:47, 146, 148, 224, 273...13, 287, 347, 497, 528...37, 49, 160, 205, 232...HERC2EEF1E1RAD17TDP1UB2D3RAD51IKPKBCLSPNDCLRE1AMCPH1XPAMRE11ARAD9ATRTP53BP1RPA2POLBRAD52SMARCAL1SP1TP53USP1PCNASMARCC2POLNMCM2PRKDCRFWD3MUTL-ALPHAMLH1BLMThe intra-S-phasecheckpoint mediatedarrest of cell cycleprogressionPLK1FANCIRBBP8UPF1PPM1DBRCA2NBNMDM2BRCA1MDC1M-Phase ProgressionFANCAXRCC5E2F1CLK2MCPH1BCL6SMC1ACHK2RAD50TRIM28CEP164EXO1CHK1MSH239, 44, 171, 199, 258...20, 150, 487174, 345, 381, 5043, 27, 106, 151, 321...125, 168, 61421, 278, 342, 399, 49445, 91, 142, 477, 592...69, 99, 245, 434, 700131, 511, 523, 590, 725192, 255, 324, 357, 374...46, 206, 271, 378, 7142, 50, 145, 269, 517...23, 92, 384, 398, 416...159, 161, 49314, 240, 514, 566, 604...55, 463, 5274, 227, 304201, 203, 302, 513, 693...120, 315, 389, 684, 719346, 425, 596113, 163, 343, 39329, 43, 188, 320, 451...282, 662, 712118, 162, 178, 301158, 332, 426, 482, 637...40, 112, 209, 274, 6301, 12, 30, 185, 194...143, 236, 336, 385, 414...32, 58, 137, 176, 219...214, 286, 310, 349, 410...73, 78, 79, 82, 140...147, 154, 387, 397, 430...27911, 307, 382, 407, 413...22, 42, 43194, 454, 531, 570, 707135, 383, 46718, 110, 191, 246, 289...128, 236, 569, 576, 643...100, 223, 594, 611, 668...34, 56, 23386, 97, 101, 127, 184...122, 126, 149, 267, 329...59, 46062, 98, 179, 242, 247...123, 198, 363, 444, 528...681348, 502, 583216, 368, 480, 495, 501...471, 581, 686174, 381, 388, 54960, 400, 447, 542, 588210, 323, 328, 591, 659...63, 169, 270, 348, 606PATM67, 180, 415, 421, 437...H2AX28, 66, 391, 394, 462...DNA Repair330, 356, 422, 461, 677RNF8229, 253, 552Cell CycleCheckpoint Activation362, 481, 515, 644, 709G2/M-Phase Checkpoint5, 334, 338Damage ProcessingDNA Polymerasedelta tetramer217139, 262, 333CDC25C70, 189, 674MRE11ARAD50NBNGammaH2AXMDC1MRNcomplex257, 290, 536, 540FANCD2FANCD2BRCA241, 48, 248, 318, 355...48, 51, 61, 95, 149...UIMC164, 164, 276, 300, 409...TOPBP126, 53, 134, 208, 522...PML7, 31, 75, 96, 107...RPA1115, 182, 192, 275, 324...BRIP1RAD1119, 251, 284, 478, 563HUS1219, 311, 543, 617, 690137, 219, 646, 651, 691...BARD1BRCC3141, 152, 239, 432, 545263, 403, 640FAM175ACDC4538, 109, 181, 202, 300...RECQL536, 165, 177, 197, 211...WRN19, 172, 187, 280, 352...74, 80, 359, 446, 449...RECQL417, 87, 264, 292, 341...RECQLRMI171, 90, 200, 228, 293...TOP3A230, 582, 65865, 277, 298, 436, 507...PARP1ssDNA77, 157, 166, 541, 568...RPA1ATRIP287, 497, 528, 532, 575...RAD9RAD1HUS19-1-1complex24, 137, 219, 250, 326...3141070632545685SHFM152, 132, 133, 183, 195...FOXM1PALB2336, 488, 49284, 299, 474, 479, 571...CycA25, 89, 116, 153, 254...Cdk2CycB15, 16, 35, 190, 220...Cdc254, 136, 153, 155, 193...G1/S boundary activation35, 295, 405, 464, 567...FEN1225, 249, 266, 360, 652...BARD1UIMC1BRCA1UIMCI-BRCA1-BARD1complex706RBBP8216, 368, 480, 501, 546...BLMRMI1TOP3ABLMcomplexInhibition pathMember of the groupIntermediate paths not shownPath to processStimulation pathRelation to pathRelation to path(intermediate steps not shown)Translocation pathCycACdk2CycBCdc2ATRATRIPCellular responseto DNA damage