miR-127 in mesendoderm differentiation (Mus musculus)

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Schematic representation depicts the mechanism of miR-127 in accelerating mesendoderm differentiation. miR-127, through the complementary pairing, suppresses the expression of Lefty2, which is referred to as antagonist to the nodal pathway. Thus, miR-127 induces p-Smad2 expression and finally up-regulates expression of mesendoderm markers.

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  1. Ma H, Lin Y, Zhao ZA, Lu X, Yu Y, Zhang X, Wang Q, Li L; ''MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2.''; J Biol Chem, 2016 PubMed Europe PMC Scholia


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92555view20:53, 15 June 2017Khansperschanged interaction from elbow to straight to avoid viz issues
92482view18:53, 8 June 2017KhanspersOntology Term : 'embryonic stem cell' added !
92477view18:20, 8 June 2017Khanspersremoved reference
92476view18:18, 8 June 2017Khanspersconnected interaction
92459view04:51, 7 June 2017KhanspersOntology Term : 'signaling pathway pertinent to development' added !
92458view04:50, 7 June 2017KhanspersModified description
92457view04:48, 7 June 2017KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
Acvr1GeneProductENSMUSG00000026836 (Ensembl)
Acvr2aGeneProductENSMUSG00000052155 (Ensembl)
Cfc1GeneProductENSMUSG00000026124 (Ensembl)
Foxa2GeneProductENSMUSG00000037025 (Ensembl)
Lefty2GeneProductENSMUSG00000066652 (Ensembl)
Mir127GeneProductENSMUSG00000070076 (Ensembl)
NodalGeneProductENSMUSG00000037171 (Ensembl)
Smad2GeneProductENSMUSG00000024563 (Ensembl)
Smad4GeneProductENSMUSG00000024515 (Ensembl)
TGeneProduct20997 (Entrez Gene)

Annotated Interactions

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