mir-193a and MVP in colon cancer metastasis (Mus musculus)

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1Cell cycle progressionMetastasisMultivesicular bodyG3bp1Caprin1mir193aMvpMycCcnd1Ccnd2mir193aMvpmir193amir193aMvpmir193aMvpmir193aMvpTumor cellCaprin1MetastasisExosomesMvp


Description

Proposed model for the mechanism of colon cancer metastasis to the liver involves exporting miR-193a via exosomes sorted by major vault protein (MVP). In pre-metastatic cells miR-193a suppresses mouse colon cancer progression by directly targeting Caprin1, which is known to positively regulate the cell cycle and cell proliferation. Higher levels of miR-193a in tumor cells causes of cell cycle G1 arrest and cell proliferation repression through reduction of Caprin1 expression. In metatstatic cells, increased levels of MVP leads to MVP-mediated selective sorting of tumor suppressor miRNA into exosomes, which promotes tumor progression.

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Bibliography

  1. Teng Y, Ren Y, Hu X, Mu J, Samykutty A, Zhuang X, Deng Z, Kumar A, Zhang L, Merchant ML, Yan J, Miller DM, Zhang HG; ''MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.''; Nat Commun, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
108126view10:28, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
92283view16:54, 18 May 2017Khanspersremove capitalization for mir193a
92268view05:17, 18 May 2017Khansperslayout improvements
92267view05:14, 18 May 2017Khansperschanged elbow to straight line
92266view05:13, 18 May 2017KhanspersModified description
92265view05:13, 18 May 2017KhanspersModified description
92264view05:09, 18 May 2017Khanspersupdated model based on author feedback
92260view23:14, 16 May 2017AlexanderPicoswitched a few more interactions
92258view23:07, 16 May 2017AlexanderPicoupdated edges and directions of effect
92257view22:43, 16 May 2017KhanspersOntology Term : 'microRNA pathway' added !
92256view22:43, 16 May 2017KhanspersOntology Term : 'altered cell cycle pathway' added !
92255view22:42, 16 May 2017Khansperschanged interaction
92254view22:41, 16 May 2017KhanspersModified description
92253view22:34, 16 May 2017KhanspersOntology Term : 'colon cancer' added !
92252view22:33, 16 May 2017KhanspersModified description
92251view22:32, 16 May 2017KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Caprin1GeneProductENSMUSG00000027184 (Ensembl)
Ccnd1GeneProductENSMUSG00000070348 (Ensembl)
Ccnd2GeneProductENSMUSG00000000184 (Ensembl)
G3bp1GeneProductENSMUSG00000018583 (Ensembl)
MvpGeneProductENSMUSG00000030681 (Ensembl)
MycGeneProductENSMUSG00000022346 (Ensembl)
mir193aRnaENSMUSG00000065395 (Ensembl)

Annotated Interactions

No annotated interactions

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