ACE Inhibitor Pathway (Mus musculus)

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1Cell MembraneAngiotensin IINos3AceAngiotensin IAgtr2BradykininBdkrb2ACE InhibitorKng1AceAgtr1AldosteroneRen1Agt


The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (

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Ontology Terms



  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia


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110700view14:09, 28 May 2020EgonwAdded missing @Type annotation
106888view13:36, 17 September 2019MaintBotHMDB identifier normalization
97382view17:28, 13 May 2018EgonwAldosterone is a metabolite
85437view09:40, 15 May 2016Egonw
85434view09:38, 15 May 2016EgonwQuick edit to datanode annotation or property
71314view17:15, 17 October 2013MaintBotAutomated update of data sources
70842view23:31, 11 September 2013Khanspersadded Wikipedia xref to ACE inhibitor
67018view09:54, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
60841view11:49, 29 March 2013EgonwFixed a metabolite which was annotated as GeneProduct.
48253view21:39, 17 May 2012KhanspersUpdating PubChem xrefs
41266view00:21, 2 March 2011MaintBotRemoved redundant pathway information and comments
35050view09:40, 11 February 2010Thomasadded literature reference
35043view09:34, 11 February 2010Thomasremoved genmapp notes (invalid link)
35042view09:32, 11 February 2010Thomasfixed metabolite annotations
35035view09:27, 11 February 2010ThomasModified description
33667view21:59, 2 December 2009KhanspersAdded connectors
21516view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:WP396]]: Moved to stable identifier
11885view18:20, 8 May 2008KhanspersChanged contact info
7874view13:46, 7 January 2008MaintBot[[Pathway:Mouse:ACE-Inhibitor pathway PharmGKB]] moved to [[Pathway:Mus musculus:ACE-Inhibitor pathway PharmGKB]]: Renaming species
7562view16:00, 18 December 2007MaintBotfixed category names
7450view12:42, 4 November 2007MaintBotAdded categories to GPML
6409view22:18, 22 May 2007C.F.Thorngpml file for [[Mouse:ACE-Inhibitor_pathway_PharmGKB]]

External references


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NameTypeDatabase referenceComment
ACE InhibitorMetaboliteCHEBI:35457 (ChEBI)
AceGeneProduct11421 (Entrez Gene)
AgtGeneProduct11606 (Entrez Gene)
Agtr1GeneProduct11607 (Entrez Gene)
Agtr2GeneProduct11609 (Entrez Gene)
AldosteroneMetaboliteC01780 (KEGG Compound)
Angiotensin IMetabolite3081372 (PubChem-compound)
Angiotensin IIMetaboliteHMDB0001035 (HMDB)
Bdkrb2GeneProduct12062 (Entrez Gene)
BradykininMetaboliteHMDB0004246 (HMDB)
Kng1GeneProduct16644 (Entrez Gene)
Nos3GeneProduct18127 (Entrez Gene)
Ren1GeneProduct19701 (Entrez Gene)

Annotated Interactions

No annotated interactions

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