H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity (Homo sapiens)

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In this proposed model, H19 interacts with macroH2A, and this may consequently lead to de-repression of genes including CDK8, CDK4, and CCND1. Increased CDK4-cyclin D1 complex phosphorylates Rb to disrupt Rb-E2F1 interaction, leading to E2F1 activation. The increase of CDK8 expression enhances the function of mediator complex including MED1, and facilitates the gene regulation by β-catenin. These downstream targets could work in a synergistic way of promoting cell proliferation and increasing cell motility in CRC. Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264449/

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  1. Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, Stiegelbauer V, Shigeyasu K, Zhang X, Chen M, Vidhu F, Bartholomeusz GA, Toiyama Y, Kusunoki M, Doki Y, Mori M, Song S, Gunther JR, Krishnan S, Slaby O, Goel A, Ajani JA, Radovich M, Calin GA; ''H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer.''; EBioMedicine, 2016 PubMed Europe PMC


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97690view00:59, 2 June 2018AlexanderPicoModified title
94706view04:13, 5 October 2017KhanspersModified description
94300view05:06, 1 September 2017Khanspersupdated layout
91527view23:01, 8 March 2017Khanspersclarified phosphorylation event
91497view23:15, 6 March 2017KhanspersOntology Term : 'colorectal cancer' added !
91496view23:14, 6 March 2017KhanspersModified description
91495view23:13, 6 March 2017KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
CCND1GeneProductENSG00000110092 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CSRP2GeneProductENSG00000175183 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
G1-S transitionPathwayWP45 (WikiPathways)
H19RnaENSG00000130600 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
MED1GeneProductENSG00000125686 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
SOX4GeneProductENSG00000124766 (Ensembl)
TULP3GeneProductENSG00000078246 (Ensembl)
macroH2AGeneProductENSG00000113648 (Ensembl)

Annotated Interactions

No annotated interactions

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